Volume 22, Issue 6 (June 2024)                   IJRM 2024, 22(6): 473-480 | Back to browse issues page

Ethics code: IR.IUMS.FMD.REC.1398.422

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Shahmoradi F, Haghighi L, Noori M, Derakhshan R, Hashemi N, Rokhgireh S. Endometriosis and adverse pregnancy outcomes: A case-control study. IJRM 2024; 22 (6) :473-480
URL: http://ijrm.ir/article-1-3263-en.html
Endometriosis and adverse pregnancy outcomes: A case-control study
Fatemeh Shahmoradi1 , Ladan Haghighi1 , Marziyeh Noori1 , Roya Derakhshan2 , Neda Hashemi3 , Samaneh Rokhgireh * 4
1- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. & Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. Department of Artificial Intelligence, Smart University of Medical Sciences, Tehran, Iran.
3- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. & Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. & Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran. , s.rokhgireh@gmail.com
Abstract:   (280 Views)
Background: The association between endometriosis and the outcome of pregnancy is one of the interesting topics. Endometriosis-related pain is alleviated with pregnancy; however, it is known to cause adverse outcomes in pregnancy. The main cause is systemic chronic inflammation caused by higher levels of cytokines, growth factors, and angiogenesis factors.
Objective: This study aimed to clarify the relationship between endometriosis, deep endometriosis, adenomyosis, surgical treatment, and poor maternal consequences.
Materials and Methods: In this case-control study, data from 250 women who gave birth in Hazrat Rasoul Akram hospital, Tehran, Iran from February 2015 to December 2019 was extracted from the hospital information system in January 2020. Participants were divided into 2 groups: 125 women with endometriosis and 125 women without endometriosis. We looked at how endometriosis affected mothers and newborn babies. Data on pregnancy, delivery, and newborns of both groups was extracted.
Results: The mean age of participants was 32.74 ± 4.10 and 31.7 ± 5.53 yr in endometriosis and control group, respectively. In terms of pregnancy complications, placenta previa, placenta accreta, placenta abruption, pre-eclampsia, gestational diabetes mellitus, and postpartum hemorrhage remarkably increased in the endometriosis group compared to the control group. Small for gestational age was significantly higher in rectal endometriosis than women without rectal endometriosis (p = 0.03). The neonatal intensive care unit admission rate was notably higher in infants of the endometriosis group compared to controls (40.7% vs. 24.8%, p = 0.009).
Conclusion: Our findings showed women with endometriosis are at a higher risk for important adverse maternal outcomes.
Keywords: Endometriosis, Pregnancy outcomes, Pre-eclampsia, Preterm birth, Cesarean section, Small for gestational age.
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Type of Study: Original Article | Subject: Pregnancy Health
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