دوره 23، شماره 8 - ( 5-1404 )                   جلد 23 شماره 8 صفحات 626-613 | برگشت به فهرست نسخه ها


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Rakhshani Moghaddam F, Razavi M. Association between matrix metalloproteinase-9 polymorphism and the risk of preeclampsia: Evidence from an updated meta-analysis. IJRM 2025; 23 (8) :613-626
URL: http://ijrm.ir/article-1-3475-fa.html
ارتباط بین پلی‌مورفیسم ژن متالوپروتئیناز ماتریکس-9 و خطر ابتلا به پره‌اکلامپسی: شواهدی از یک متاآنالیز به‌روزرسانی‌شده. International Journal of Reproductive BioMedicine. 1404; 23 (8) :613-626

URL: http://ijrm.ir/article-1-3475-fa.html


چکیده:   (100 مشاهده)
مقدمه: پره‌اکلامپسی (PE)، یکی از شایع­ترین اختلالات فشار خون بارداری (HDP) است که با افزایش فشار خون به همراه پروتئینوری تشخیص داده می‌شود. مطالعات متعددی تأثیر پلی‌مورفیسم MMP-9-1562 را بر خطر ابتلا به پره‌اکلامپسی در کشورهای مختلف بررسی کرده‌اند، اما نتایج این مطالعات متناقض بوده است.
هدف: هدف از این متاآنالیز، بررسی ارتباط بین پلی‌مورفیسم MMP-9-1562 و حساسیت ابتلا به پره‌اکلامپسی بود.
مواد و روش­ ها: پژوهش‌های واجد شرایط با جستجو در پایگاه‌های اطلاعاتی اینترنتی از جمله Scopus، PubMed و Google Scholar شناسایی شدند. معیارهای ورود شامل مطالعات مورد-شاهدی یا کوهورت بود که نقش پلی‌مورفیسم MMP-9-1562 را در بروز پره‌اکلامپسی بررسی کرده و اطلاعات فراوانی ژنوتیپ را در هر دو  گروه بیماران و کنترل گزارش کرده بودند. تحلیل داده‌ها با استفاده از ابزار تحت وب MetaGenyo انجام شد.
نتایج: نتایج نشان داد که واریانت MMP-9-1562 با افزایش خطر ابتلا به پره‌اکلامپسی در مدل‌های ژنتیکی غالب، بیش‌غالب، و هتروزیگوت هم‌غالب مرتبط است. تحلیل زیرگروه بر اساس قومیت نشان داد که این افزایش خطر در زنان با قومیت برزیلی در مدل‌های بیش‌غالب و هم‌غالب هتروزیگوت قابل توجه است. ناهمگنی بین مطالعات در مدل‌های ژنتیکی آللی، غالب، بیش‌غالب، و هم‌غالب هتروزیگوت مشاهده شد.
نتیجه­ گیری: این متاآنالیز نشان داد که MMP-9-rs3918242 ممکن است با افزایش حساسیت به پره‌اکلامپسی همراه باشد.
نوع مطالعه: Review article |

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