پنجشنبه 30 بهمن 1404
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دوره 23، شماره 11 - ( 8-1404 )
جلد 23 شماره 11 صفحات 896-881 |
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Baradaran Bagheri R, Mohammadian S. Unveiling the molecular nexus: Long non-coding RNAs, RNA-binding proteins, and DNA damage in ovarian ischemia-reperfusion injury: A narrative review. IJRM 2025; 23 (11) :881-896
URL: http://ijrm.ir/article-1-3693-fa.html
URL: http://ijrm.ir/article-1-3693-fa.html
نقش رونوشتهای بلند غیرکُدکننده (lncRNAs)، پروتئینهای متصلشونده به RNA و آسیب DNA در آسیب ایسکمی/پرفیوژن تخمدان: یک مرور روایتی. International Journal of Reproductive BioMedicine. 1404; 23 (11) :881-896
چکیده: (165 مشاهده)
آسیب ایسکمی/پرفیوژن تخمدان که با نام پیششرطیسازی هایپراُکسیک تخمدان نیز شناخته میشود، پاتولوژیای است که با قطع جریان خون تخمدان و بازگشت آن همراه بوده و موجب آسیب و اختلال عملکرد میگردد. بنابراین، شناسایی اجزای مولکولی از جمله lncRNA ها و پروتئینهای متصلشونده به RNA (RBP ها) و همچنین نقش آنها در پاسخ به آسیب DNA، برای درک مکانیسمهای زیربنایی و یافتن اهداف درمانی بالقوه اهمیت دارد. الگوی بیان lncRNA و تنظیم پاسخ به آسیب DNA در فرایندهای سلولی مختلف میتواند از طریق تعامل با پروتئینهای متصلشونده به RNA کنترل شود. lncRNA ها با ایفای نقش بهعنوان داربست، راهنما یا تله در تنظیم فرایندهای RNA، میانجیگری در ترمیم DNA و پاسخهای سلولی دیگر به استرس ژنوتوکسیک عمل میکنند. تغییر در تعامل lncRNA–RBP در بیماریهای متعددی از جمله آسیب ایسکمی/پرفیوژن تخمدان (IRI) دخیل بوده و بررسی بیشتر آنها را بهعنوان اهداف درمانی ضروری میسازد. اختلال در RBP ها منجر به برهمخوردن هموستاز RNA، کاهش ترمیم DNA و تشدید آسیب بافتی ناشی از IRI در تخمدانها میشود. این مسیرها در تنظیم چرخه سلولی، ترمیم DNA و تنظیم آپوپتوز در IRI تخمدان دخیلاند و دستکاری این مسیرها بهوسیله lncRNA ها و RBP های معرفیشده میتواند در پیشرفت بیماری و/یا هدفگذاری درمانی مؤثر باشد. مطالعه این فرایندهای مولکولی چشماندازی نویدبخش برای درمانهای «تقریباً هدفمند» و فردمحور فراهم میآورد. مطالعات آینده باید به بررسی سهم افتراقی lncRNA ها و RBP های خاص و همچنین مسیرهای پاسخ به آسیب DNA در IRI تخمدان بپردازند تا برآورد پیشآگهی بهتری ارائه شود و عملکرد تخمدان در بیماران بهبود یابد.
نوع مطالعه: Review article |
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