Volume 11, Issue 5 (7-2013)                   IJRM 2013, 11(5): 365-0 | Back to browse issues page

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Fallah R, Akhavan Karbasi S, Galalian M T, Dehghani-Firouzabadi R. Comparison of developmental status of 5-year-old singleton children born through assisted and natural conceptions. IJRM 2013; 11 (5) :365-0
URL: http://ijrm.ir/article-1-425-en.html
Comparison of developmental status of 5-year-old singleton children born through assisted and natural conceptions
Razieh Fallah1 , Sedighah Akhavan Karbasi * 2, Mohammad Taghi Galalian3 , Razieh Dehghani-Firouzabadi4
1- Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , sakarbasi@yahoo.com
3- Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (2478 Views)
Background: Approximately one percent of current live births of the world are conceived via assisted reproductive technologies (ART).
Objective:  The purpose of this study was to compare the developmental status of children born through assisted and natural conceptions at the age of five years.
Materials and Methods:  In a retrospective cohort study, developmental status of 5 years old children was evaluated via Persian version of 60-month Ages and Stages Questionnaires. Case group consisted of 61 singletons, term babies whom were born through ART in the Research and Clinical Center for Infertility, Yazd, Iran in 2005. Control group consisted of 61 term, first child, singleton and spontaneously conceived born five years old children whom were referred to Shahid Akbari primary health care center in 2010.
Results:  58 girls (47.5%) and 64 boys (52.5%) were evaluated. Frequency of developmental delay in domains of fine motor (47.5% vs. 24.6%, p=0.008) and problem solving (60.6% vs. 34.4%, p=0.004) were more in ART born children. On logistic regression, fine motor development state was independently affected by maternal educational level (OR: 5.3, 95% CI: 1.67-16.30, p=0.004) and developmental status in problem solving domains was independently affected by maternal educational level (OR: 4.88, 95% CI: 1.25-19.07, p=0.02) and birth weight (OR: 7.1, 95% CI: 1.78-29.01, p=0.006).
Conclusion:  Maternal educational level and birth weight are important factors that influenced developmental outcome of ART born children.
Keywords: In-Vitro fertilization, Assisted reproductive technologies, Outcome, Child development, ASQ (Ages and Stages questionnaire)
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Type of Study: Original Article |
References
1. Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet 1978; 12: 366. [DOI:10.1016/S0140-6736(78)92957-4]
2. Fortunato A, Tosti E. The impact of in vitro fertilization on health of the children: an update. Eur J Obstet Gynecol Reprod Biol 2011; 154: 125-129. [DOI:10.1016/j.ejogrb.2010.10.012]
3. Mohammad K, Ardalan A. An overview of the epidemiology of primary infertility in Iran. J Reprod Infertil 2009; 10: 213-216.
4. Aflatounian A, Seyed Hasani SM, Tabibnezhad N. The epidemiological and etiological aspects of infertility in Yazd province of Iran. Iran J Reprod Med 2009; 7: 117-122.
5. Leslie GI. Mental development of children conceived using intracytoplasmic sperm injection. The current evidence. Minerva Ginecol 2004; 56: 247-257.
6. La Sala GB, Gallinelli A, Fagandini P, Bevolo P, Landini A, Ballabeni A, et al. Developmental outcomes at one and two years of children conceived by intracytoplasmic sperm injection. Int J Fertil Womens Med 2004; 49: 113-119.
7. Hvidtjørn D, Grove J, Schendel DE, Vaeth M, Ernst E, Nielsen LF, et al. Cerebral palsy among children born after in vitro fertilization: the role of preterm delivery--a population-based, cohort study. Pediatrics 2006; 118: 475-482. [DOI:10.1542/peds.2005-2585]
8. Johnson S, Marlow N. Developmental screen or developmental testing? Early Hum Dev 2006; 82: 173-183. [DOI:10.1016/j.earlhumdev.2006.01.008]
9. Yassini M, Khalili MA, Hashemian Z. The level of anxiety and depression among Iranian infertile couples undergoing in vitro fertilization or intra cytoplasmic sperm injection cycles. J Res Med Sci 2005; 10: 358-362.
10. Gollenberg AL, Lynch CD, Jackson LW, McGuinness BM, Msall ME. Concurrent validity of the parent-completed Ages and Stages Questionnaires, 2nd Ed. with the Bayley Scales of Infant Development II in a low-risk sample. Child Care Health Dev 2010; 36: 485-490. [DOI:10.1111/j.1365-2214.2009.01041.x]
11. Fallah R, Islami Z, Mosavian T. Developmental status of NICU admitted low birth weight preterm neonates at 6 and 12 months of age using Ages and Stages Questionnaire. Iran J Child Neurol 2011; 5: 21-28.
12. Johnson S, Marlow N. Developmental screen or developmental testing? Early Hum Dev 2006; 82: 173-183. [DOI:10.1016/j.earlhumdev.2006.01.008]
13. Belva F, Henriet S, Liebaers I, Van Steirteghem A, Celestin-Westreich S, Bonduelle M. Medical outcome of 8-year-old singleton ICSI children (born >or=32 weeks' gestation) and a spontaneously conceived comparison group. Hum Reprod 2007; 22: 506-515. [DOI:10.1093/humrep/del372]
14. Wittemer C, Machev N, Viville S. [Follow-up of children born by ICSI]. Med Sci (Paris) 2004; 20: 352-356. (Article in French) [DOI:10.1051/medsci/2004203352]
15. Sebastiani G, Pertierra Cortada A, Vidal Sordé E, Figueras Aloy J, Balasch Cortina J. [Factors associated with assisted reproduction technologies and neonatal outcomes]. An Pediatr (Barc) 2009; 70: 323-332. (Article in Spanish) [DOI:10.1016/j.anpedi.2009.01.011]
16. Söderström-Anttila V, Salokorpi T, Pihlaja M, Serenius-Sirve S, Suikkari AM. Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes. Hum Reprod 2006; 21: 1508-1513. [DOI:10.1093/humrep/dei503]
17. Bowen JR, Gibson FL, Leslie GI, Saunders DM. Medical and developmental outcome at 1 year for children conceived by intracytoplasmic sperm injection. Lancet 1998; 351: 1529-1534. [DOI:10.1016/S0140-6736(98)10168-X]
18. Knoester M, Helmerhorst FM, Vandenbroucke JP, van der Westerlaken LA, Walther FJ, Veen S. Leiden Artificial Reproductive Techniques Follow-up Project. Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception. Fertil Steril 2008; 90: 289-296. [DOI:10.1016/j.fertnstert.2007.06.090]
19. Knoester M, Vandenbroucke JP, Helmerhorst FM, van der Westerlaken LA, Walther FJ, Veen S. Matched follow-up study of 5-8 year old ICSI-singletons: comparison of their neuromotor development to IVF and naturally conceived singletons. Hum Reprod 2007; 22: 1638-1646. [DOI:10.1093/humrep/dem040]
20. Ponjaert-Kristoffersen I, Bonduelle M, Barnes J, Nekkebroeck J, Loft A, Wennerholm UB, et al. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics 2005; 115: e283-289. [DOI:10.1542/peds.2004-1445]
21. Leslie GI, Gibson FL, McMahon C, Cohen J, Saunders DM, Tennant C. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age .Hum Reprod 2003; 18: 2067-2072. [DOI:10.1093/humrep/deg408]
22. Basatemur E, Sutcliffe A. Follow-up of Children Born after ART. Placenta 2008; 29: S135-140. [DOI:10.1016/j.placenta.2008.08.013]
23. Nekkebroeck J, Bonduelle M, Desmyttere S, Van den Broeck W, Ponjaert-Kristoffersen I. Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/ screening. Hum Reprod 2008; 23: 1560-1566. [DOI:10.1093/humrep/den033]
24. Gibson FL, Ungerer JA, Leslie GI, Saunders DM, Tennant CC. Development, behaviour and temperament: a prospective study of infants conceived through in-vitro fertilization. Hum Reprod 1998; 13: 1727-1732. [DOI:10.1093/humrep/13.6.1727]
25. McDonald SD, Han Z, Mulla S, Murphy KE, Beyene J, Ohlsson A. Knowledge Synthesis Group .Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol 2009; 146: 138-148. [DOI:10.1016/j.ejogrb.2009.05.035]
26. Tough SC, Greene CA, Svenson LW, Belik J. Effects of in vitro fertilization on low birth weight, preterm delivery, and multiple birth. J Pediatr 2000; 136: 618-622. [DOI:10.1067/mpd.2000.105132]
27. Reuner G, Hassenpflug A, Pietz J, Philippi H. Long-term development of low-risk low birth weight preterm born infants: neurodevelopmental aspects from childhood to late adolescence. Early Hum Dev 2009; 85: 409-413. [DOI:10.1016/j.earlhumdev.2009.01.007]
28. Datar A, Jacknowitz A. Birth weight effects on children's mental, motor, and physical development: evidence from twins data. Matern Child Health J 2009; 13: 780-794. [DOI:10.1007/s10995-009-0461-6]
29. Boardman JD, Powers DA, Padilla YC, Hummer RA. Low birth weight, social factors, and developmental outcomes among children in the United States. Demography 2002; 39: 353-368. [DOI:10.1353/dem.2002.0015]
30. Karimi M, Fallah R, Dehghanpoor A, Mirzaei M. Developmental status of 5-year-old moderate low birth weight children. Brain Dev 2011; 33: 651-655. [DOI:10.1016/j.braindev.2010.10.022]
31. Lindsay NM, Healy GN, Colditz PB, Lingwood BE. Use of the Ages and Stages Questionnaire to predict outcome after hypoxic-ischaemic encephalopathy in the neonate. J Paediatr Child Health 2008; 44: 590-595. [DOI:10.1111/j.1440-1754.2008.01388.x]
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