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Reproductive Biomedicine
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Volume 4, Issue 1 (7-2006)
IJRM 2006, 4(1): 35-39 |
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Dehghan M H, Dehghanan R. Plasma level of vitamin C in women with pre-eclampsia in Ardabil, Iran. IJRM 2006; 4 (1) :35-39
URL: http://ijrm.ir/article-1-43-en.html
URL: http://ijrm.ir/article-1-43-en.html
1- Department of Biochemistry, Ardabil University of Medical Sciences, Ardabil, Iran , mh.dehghan@arums.ac.ir
2- Ardabil Educational Organization, Ardabil, Iran
2- Ardabil Educational Organization, Ardabil, Iran
Abstract: (2834 Views)
Background: Pre-eclampsia, a vascular disorder of pregnancy, is a leading cause of maternal morbidity as well as perinatal morbidity and mortality. The cause of pre-eclampsia remains largely unknown. Accumulating evidences from clinical and epidemiological studies suggest that diffuse endothelial dysfunction, resulting from oxidative stress, plays an important role in the pathogenesis of pre-eclampsia. Independent effect of maternal biological markers, such as elevated triglyceride or low plasma vitamin C (ascorbic acid) concentrations are related to increased pre-eclampsia risk.
Objectives: The aim of this study was to determine plasma concentrations of vitamin C in women with pre-eclampsia.
Materials and Methods: This cross-sectional, case controlled study comprises 40 pre-eclamptic and 80 normo-tensive pregnant women of singleton gestations in third trimester, in Allavi Hospital, Ardabil, Iran. Blood samples (5ml) were collected aseptically in heparin tube, and the plasma concentration of vitamin C was determined by spectrophotometric method . SPSS software package was used for analyzing the data.
Results: Plasma vitamin C level was found to be significantly lower (p<0.001) in the pre-eclampsia group than this level in the control group. Vitamin C levels in the pre-eclampsia group were found to be influenced by their maternal age (p<0.01), and was positively related to the gestational age (p<0.01).
Conclusion: Knowledge from this study may contribute to the development and evaluation of behavioral and medical interventions aimed at reducing the occurrence of pre-eclampsia.
Objectives: The aim of this study was to determine plasma concentrations of vitamin C in women with pre-eclampsia.
Materials and Methods: This cross-sectional, case controlled study comprises 40 pre-eclamptic and 80 normo-tensive pregnant women of singleton gestations in third trimester, in Allavi Hospital, Ardabil, Iran. Blood samples (5ml) were collected aseptically in heparin tube, and the plasma concentration of vitamin C was determined by spectrophotometric method . SPSS software package was used for analyzing the data.
Results: Plasma vitamin C level was found to be significantly lower (p<0.001) in the pre-eclampsia group than this level in the control group. Vitamin C levels in the pre-eclampsia group were found to be influenced by their maternal age (p<0.01), and was positively related to the gestational age (p<0.01).
Conclusion: Knowledge from this study may contribute to the development and evaluation of behavioral and medical interventions aimed at reducing the occurrence of pre-eclampsia.
Type of Study: Original Article |
References
1. Villar K, Say L, Gülmezoglu AM, Merialdi M, Lindheimer MD, Betran AP, Piaggio G. Eclampsia and pre-eclampsia: a health problem for 2000 years. In: Critchley H, MacLean AB, Poston L, Walker JJ, eds. Pre-eclampsia. London: RCOG Press 2003; 189-207.
2. Walker JJ: Pre-eclampsia. Lancet 2000; 356:1260-1265. [DOI:10.1016/S0140-6736(00)02800-2]
3. Nelson-Piercy C. Pre-eclampsia: the women at risk. In: Critchley H, MacLean AB, Poston L, Walker JJ, eds. Pre-eclampsia. London: RCOG Press 2003; 342-353.
4. Staff AC, Ranheim T, Khoury J, Henriksen T. Increased contents of phopholipids, cholesterol, and lipid peroxides in decidua basalis in women with pre-eclampsia. Am J Obstet Gynecol 1999; 180: 587-592. [DOI:10.1016/S0002-9378(99)70259-0]
5. Madazli R, Benian A, Gumustas K, Uzun H, Ocak V, Aksu F. Lipid peroxidation and antioxidants in pre-eclampsia. Eur J Obstet Gynecol Reproduct Biol 1999; 85: 205-208. [DOI:10.1016/S0301-2115(99)00023-8]
6. Hubel CA, Kozlov AV, Kagan VE, Evans RW, Davidge ST, McLaughlin MK, Roberts JM. Decreased transferring and increased transferrin saturation in sera of women with pre-eclamsia. Implications for oxidative stress. Am J Obstet Gynecol 1997;175: 692-700. [DOI:10.1053/ob.1996.v175.a74252]
7. Gulmezoglu AM, Hofmeyr GJ, Oosthuisen MMJ. Antioxidants in the treatment of severe pre-eclampsia. an explanatory randomised trial. Br J Obstet Gynecol 1997; 104: 689-696. [DOI:10.1111/j.1471-0528.1997.tb11979.x]
8. Shaarawy M, Aref A, Salem ME, Sheiba M. Radical-scavenging antioxidants in pre-eclampsia and eclampsia. Int J Gynecol Obstet 1998; 60: 123-128. [DOI:10.1016/S0020-7292(97)00256-7]
9. Llurba E, Gratacos E, Martin-Gallan P, Cabero L, Dominguez C. A comprehensive study of oxidative stress and antioxidant status in pre-eclampsia and normal pregnancy. Free Radic Biol Med 2004; 37: 557-570. [DOI:10.1016/j.freeradbiomed.2004.04.035]
10. Freeman C. Free radicals and tissue injury. Lab Invest 1982; 47: 412-426.
11. Gryglewski RJ, Palmer RMJ, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986; 320: 454-456. [DOI:10.1038/320454a0]
12. Wang Y, Walsh SW, Guo J, Zhang J. Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. Am J Obstet Gynecol 1991; 165: 1690-1694. [DOI:10.1016/0002-9378(91)90016-K]
13. Weiss SJ, Turk J, Needleman P. A mechanism for hydroperoxide mediated inactivation of prostacyclin synthetase. Blood 1979; 208: 1191-1196.
14. Ehrenkrarnz RA. Vitamin E and the neonate. Arch Pediatr Adoles Med 1980; 134:1157-1166. [DOI:10.1001/archpedi.1980.02130240041013]
15. Mayes PA . Structure and function of lipid soluble vitamins. In: Herper's Biochemistry. 24th edition. Murray RK, Granner DK, Mayes PA, Rodwell VW (eds). Appleton and Lange, Connecticut.1996; 614-624.
16. Czerinichow S, Hercberg S .International studies concerning the role of antioxidant vitamins in cardiovascular diseases: a review. J Nutr Health Aging 2001;5(3): 188-195.
17. Diplock AT. Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutr 1991; 53: 1893-1935.
18. Dakshinamuti K, Dakshinamuti S. Blood pressure regulation and micronutrients. Nutr Res Review 2001; 14: 3-43. [DOI:10.1079/095442201108729123]
19. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 1989; 86: 6377-6381. [DOI:10.1073/pnas.86.16.6377]
20. Raijmakers MT, Dechend R, Poston L. Oxidative stress and preeclampsia: rationale for antioxidant clinical trials. Hypertension 2004; 44:374-380. [DOI:10.1161/01.HYP.0000141085.98320.01]
21. Gifford RW, August PA, Cunningham G, Green LA, Lindheimer MD, McNellis D, et al. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22. [DOI:10.1067/mob.2000.107928]
22. Kyaw A. A simple colorimetric method for ascorbic acid determination in blood, plasma. Clin Chim Acta 1978; 86:153-157. [DOI:10.1016/0009-8981(78)90128-6]
23. Sies H. Oxidative stress II. Oxidants and antioxidants. Academic Press, London 1991.
24. Page KR. The physiology of human placenta. UCL Press Limited, London 1993;164.
25. Fridovich I. Hypoxia and oxygen toxicity. Adv Neurol 1979; 26: 255-259.
26. Liochev SI, Friedovich I. How does superoxide dismutase protect against tumor necrosis factor: a hypothesis informed by effect of superoxide on ''free'' iron. Free Radic Biol Med 1997; 23: 668-671. [DOI:10.1016/S0891-5849(97)00060-9]
27. Romero R. Intrauterine infection, premature birth and the Fetal Inflammatory Response Syndrome. J Nutr 2003; 133: 1668S-1673S. [DOI:10.1093/jn/133.5.1668S]
28. Casanueva E, Magan AL, Pfeffer F, Baez A. Incidence of premature rupture of membranes in pregnant women with low leukocyte levels of vitamin C. Eur J Clin Nutr 1991; 45: 401-405.
29. Choi JL, Rose RC. Transport and metabolism of ascorbic acid in human placenta. Am J Physiol 1989; 257: c110-c113. [DOI:10.1152/ajpcell.1989.257.1.C110]
30. Schiff E, Friedman SA, Stampfer M, Kao L,Barrett PH, Sibai BM. Dietary consumption and plasma concentrations of vitamin E in pregnancies Complicated by pre-eclampsia. Am J Obstet Gynecol 1996; 175: 1024-1028. [DOI:10.1016/S0002-9378(96)80046-9]
31. Niki E, Saito T, Kawakami A, Kamiya Y. Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C. J Biol Chem 1984; 259:4177-4182
32. Lindeman JHN, Grobben DVZ, Schrijver J, Speek AJ, Poorthuis BJHM, Berger HM. The total free radical trapping ability of cord blood plasma in preterm and term babies. Pediatr Res 1989; 26:20-24. [DOI:10.1203/00006450-198907000-00008]
33. Uotila JT, Tuimala RJ, Aarnio TM. Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Br J Obstet Gynaecol 1993; 100:270-276. [DOI:10.1111/j.1471-0528.1993.tb15242.x]
34. Kharb S. Total free radical trapping antioxidant potential in pre-eclampsia. Int J Gynecol Obstet 2000; 39:23-26 [DOI:10.1016/S0020-7292(99)00198-8]
35. Kharb S. Vitamins E & C in pre-eclampsia. Eur J Obstet Gynecol Reproduct Biol 2001; 1: 195-197
36. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biolo Endocrinol 2005; 3:28. [DOI:10.1186/1477-7827-3-28]
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