Volume 11, Issue 8 (11-2013)                   IJRM 2013, 11(8): 659-0 | Back to browse issues page

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Shekouhi S, Baghbani F, Hasanzadeh Nazar-Abadi M, Hamzehloie T, Abbaszadegan M R, Saghafi N, et al . Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family. IJRM 2013; 11 (8) :659-0
URL: http://ijrm.ir/article-1-447-en.html
Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family
Sahar Shekouhi1 , Fatemeh Baghbani1 , Mohammad Hasanzadeh Nazar-Abadi1 , Tayebeh Hamzehloie1 , Mohammad Reza Abbaszadegan1 , Nafiseh Saghafi2 , Reza Raoofian1 , Javad Zavar Reza3 , Shahab Ahmadzadeh1 , Mohammad Amin Tabatabaiefar4 , Majid Mojarrad * 5
1- Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Gynecology, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , Mojaradm@mums.ac.ir
Abstract:   (2209 Views)
Background: Recurrent spontaneous abortion (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified.
Objective: In this study we performed linkage analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA.
Materials and Methods: A linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-linked RSA. Two point parametric Linkage was performed using Superlink v 1.6 program.
Results: Evidence of linkage was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively.
Conclusion: Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this gene.
Keywords: X-linked, Recurrent spontaneous abortion, Linkage.
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Type of Study: Original Article |
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