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دوره 4، شماره 1 - ( 4-1385 )
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Farimani M, Amiri I, Hoseini S. Day 3 serum inhibin-B level is not predictive of ovarian assisted reproductive technologies outcome. IJRM 2006; 4 (1) :1-5
URL: http://ijrm.ir/article-1-49-fa.html
URL: http://ijrm.ir/article-1-49-fa.html
Day 3 serum inhibin-B level is not predictive of ovarian assisted reproductive technologies outcome. International Journal of Reproductive BioMedicine. 1385; 4 (1) :1-5
چکیده: (3233 مشاهده)
Background: The ability of the ovary to respond to exogenous gonadotrophin stimulation and development of several follicles is essential in assisted reproductive technology. Neither age and regularity of menses nor follicular phase FSH and estradiol concentrations are reliable predictors of ovarian response. Day 3 serum inhibin-B level, during induction ovulation, has been proposed as a predictor of ovarian response.
Objective: To determine day 3 serum inhibin-B as a predictor of ovarian response to induction ovulation in IVF/ ICSI cycles.
Materials and Methods: Seventy one infertile patients under 40 years old were enrolled in this study. All women have both ovaries, basal FSH level under 15 mIU/ml, and no evidence of endocrine disorders. Day 3 FSH, estradiol, inbibin-B concentrations and ovarian volume were measured before treatment. All patients underwent standard long GnRH agonist protocol. The number of oocytes retrieved, fertilization rate, clinical pregnancy rate, days of stimulation and number of HMG ampoules were determined. The patients were divided into two groups, normal responders and poor responders (number of oocytes retrived <4).
Results: The mean inhibin-B level in normal responders was 166.9 141 pg/ ml versus 115.8 87 pg/ml in poor responders, which the difference was not statistically significant (p=0.24). We could not find a cut off between normal and poor responders.
Conclusion: The use of day 3 inhibin-B level as a predictive marker of ovarian response in IVF/ICSI cycles is not reliable.
Objective: To determine day 3 serum inhibin-B as a predictor of ovarian response to induction ovulation in IVF/ ICSI cycles.
Materials and Methods: Seventy one infertile patients under 40 years old were enrolled in this study. All women have both ovaries, basal FSH level under 15 mIU/ml, and no evidence of endocrine disorders. Day 3 FSH, estradiol, inbibin-B concentrations and ovarian volume were measured before treatment. All patients underwent standard long GnRH agonist protocol. The number of oocytes retrieved, fertilization rate, clinical pregnancy rate, days of stimulation and number of HMG ampoules were determined. The patients were divided into two groups, normal responders and poor responders (number of oocytes retrived <4).
Results: The mean inhibin-B level in normal responders was 166.9 141 pg/ ml versus 115.8 87 pg/ml in poor responders, which the difference was not statistically significant (p=0.24). We could not find a cut off between normal and poor responders.
Conclusion: The use of day 3 inhibin-B level as a predictive marker of ovarian response in IVF/ICSI cycles is not reliable.
نوع مطالعه: Original Article |
فهرست منابع
1. Scott RT, Hofmann GE. Prognostic assessment of ovarian reserve. Fertil Steril 1995; 63; 1-11. [DOI:10.1016/S0015-0282(16)57287-2]
2. Sharara F, Scott RT. Assessmant of ovarian reserve and treatment of low responders. Infertil Reprod Med Clin North Amer 1997;8:501-522.
3. Navot D, Rosenwaks Z, Margalioth EJ. Prognostic assessment of female fecundity. Lancet 1997; 2: 645-647. [DOI:10.1016/S0140-6736(87)92439-1]
4. Scott RT, Toner JP, Muasher SJ, Oehninger S, Robinson S, Resenwaks Z. Follicle- stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril 1989;51: 651-654. [DOI:10.1016/S0015-0282(16)60615-5]
5. Muasher SJ, Oehninger S, Simonetti S. The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril 1988; 50: 298-307. [DOI:10.1016/S0015-0282(16)60077-8]
6. Toner JP, Philput CB, Jones GS, Muasher SJ. Basal follicle - stimulating hrmone level is a better predictor of in vitro fertilization performance than age. Fertil Steril 1991; 55: 784-791. [DOI:10.1016/S0015-0282(16)54249-6]
7. Yong Y, Baird D,Thong K, Neily A, Anderson R. Prospective analysis of the relationship between the ovarian follicle cohort and basal FSH concentration, the inhibin response to exogenous FSH and ovarian follicle number at different stages of normal menstrual cycle and after pituitary down-regulation. Hum Reprod 2003;18(1):35-44. [DOI:10.1093/humrep/deg019]
8. Evers JL, Slaats P, Land JA, Dumoulin JC, Dunselman GA. Elevated levels of basal estradiol- 17B predict poor response in patients with normal basal levels of follicle-stimulating hormone undergoing in vitro fertilization. Fertil Steril 1998; 69: 1010-1014. [DOI:10.1016/S0015-0282(98)00080-6]
9. Smotrich DB, Widra EA, Gindoff PR, Levy MJ, Hall JL, Stillman RJ. Prognostic value of day 3 estradiol on in vitro fertilization outcome. Fertil steril 1995; 64: 1136- 1140. [DOI:10.1016/S0015-0282(16)57974-6]
10. Syrop CHW, lhoite A, Van Voorhis BJ. Ovarian volume a novel outcome predictor assisted reproduction. Fertil Streil 1995; 64: 1167- 1171. [DOI:10.1016/S0015-0282(16)57979-5]
11. Bancsi M, Broekmans FJ. Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril 2002; 77: 328-337. [DOI:10.1016/S0015-0282(01)02983-1]
12. Tsuchiya K, Seki M, Itoh M, Hasegawa Y, Miyamoto K, Igarashi M. Correlation of serum inhibin concentrations with results in an ovarian hyperstimulation program. Fertil Steril 1989;52, 88-94. [DOI:10.1016/S0015-0282(16)60795-1]
13. Hughes EG, Robertson DM, Handelsman DJ, Hayward S, Healy DL, Kretser DM de. Inhibin and estradiol responses to ovarian hyperstimulation: effects of age and predictive value for in vitro fertilization outcome. J Clin Endocrinol Metab 1990; 70: 358-364. [DOI:10.1210/jcem-70-2-358]
14. Ohshima K, Kishi H, Itoh M, Arai KY, Watanabe G, Arai K, et al. Secretory pattern of inhibin A, inhibin B and inhibin pro-α C during induced follicular atresia and subsequent follicular development in the golden hamster (Mesocricetus auratus). J Endocrinol 2002;171:575-581. [DOI:10.1677/joe.0.1720575]
15. Nancy A, Brenda S, Karl R, Teresa K, Patrick M, William J, Michael R. Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women. Clin Endocrinol Metab 2004; 89(6): 2977-2981. [DOI:10.1210/jc.2003-031515]
16. Corrine K, Welt Zachary A, Smith Donna K, Hall JE. Differential Regulation of Inhibin A and Inhibin B by Luteinizing Hormone, Follicle-Stimulating Hormone, and Stage of Follicle Development. Clin Endocrinol Metab 2001; 86(6): 2531-2537. [DOI:10.1210/jc.86.6.2531]
17. Casper F, Scufert R, Pollow K. Inversa correlation between basline inhibin B and FSH after stimulation with GnRH: a study of serum levels of inhibin A and B, pro alpha-C and activin A in women with ovulatory disturbances before and after stimulation with GnRH. E J Endocrinol 2000;143:77-84. [DOI:10.1530/eje.0.1430077]
18. Klein NA, IIIingworth PJ, Groome NP, McNeilly A, Battaglia D, Soules MR. Decreased inhibin B secretion is associated with the monotropic FSH rise on older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab 1996;81: 2742- 2745. [DOI:10.1210/jcem.81.7.8675606]
19. Danforth D, Arbogast L , Mroueh J, Kim H, Kennard A, Seifer B, Friedman I. Dimeric inhibin: a direct marker of ovarian aging. Fertil Steril 1998 ; 70: 119- 123. [DOI:10.1016/S0015-0282(98)00127-7]
20. Seifer DB, Lambert-Messerlian G, Gardiner AC, Blazer AS, Berk CA. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertil Steril 1997; 67: 110-114 [DOI:10.1016/S0015-0282(97)81865-1]
21. Seifer B, Scott, RT, Bergh PA, Abrogast LK, Friedman CI, Mack CK, Danforth DR. Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle stimulating hormone. Fertil Steril 1999; 72: 63-65. [DOI:10.1016/S0015-0282(99)00193-4]
22. Matson PL, Morris D, Sun JG, Ibrahim ZH, Lieberman BA. Serum inhibin as an index of ovarian function in women undergoing pituitary suppression and ovarian stimulation in an in vitro fertilization program. Horm Res 1991: 35, 173-177. [DOI:10.1159/000181897]
23. Balasch J, Creus M, Fabregues F, Carmona F, Casamitjana R, Ascaso C, Vanrell JA. Inhibin, follicle-stimulating hormone and age as predictors of ovarian response in in vitro fertilization cycles stimulated with gonadotropin-releasing hormone agonist-gonadotropin treatment. Am J Obstet Gynecol 1996; 127: 1226-1230. [DOI:10.1016/S0002-9378(96)70032-7]
24. Lockwood GM, Muttukrishna S, Groome NP, Ledger WL. Circulating inhibins and activin A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in-vitro fertilization-embryo transfer. Clin Endocrinol 1996; 45: 741-748. [DOI:10.1046/j.1365-2265.1996.8510861.x]
25. Corson SL, Gutmann J, Batzer FR, Wallace H, Klein N, Soules MR. Inhibin B as a test of ovarian reserve for infertile women. Hum Reprod 1999; 14: 2818-2821. [DOI:10.1093/humrep/14.11.2818]
26. Elder-Geva T, Margalioth EJ, Ben-Chetrit A, Robertson D, Healy DL, Diamanat Y. Serum inhibin B levels measured early during FSH administration for IVF may be of value in predicting the number of oocytes to be retrived in normal and low responders. Hum Reprod 2002;17(9): 2331-2337. [DOI:10.1093/humrep/17.9.2331]
27. Hall E, Welt CK, Gramer DW. Inhibin A and inhibin B reflect ovarian function in assisted reproduction but are less useful at predicting outcome. Hum Reprod 1999; 14: 409-415. [DOI:10.1093/humrep/14.2.409]
28. Tinkanen H, Blauer M, Laipala P, Tuohimaa P, Kujansuu E. Prognostic factors in controlled ovarian hyperstimulation. Fertil Steril 1999; 27: 932- 936. [DOI:10.1016/S0015-0282(99)00397-0]
29. Creus M, Penarrubia A, Fabregues F, Vidal E, Carmona F, Casamitjana R, et al. Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome. Hum Reprod 2000;15: 2341- 2346. [DOI:10.1093/humrep/15.11.2341]
30. Revhon A, Lavery S, Michel S, Donaldson M, Margara R, Trew G, Winston R. Dynamic assays of inhibin B and osetradiol following buserelin acetate administrastion as predictors of ovarian response in IVF. Hum Reprod 2000; 15: 2297- 2301. [DOI:10.1093/humrep/15.11.2297]
31. Dumesic D, Damario A, Session R, Famuyide A, Lesnick TG, Thornhill R, McNeilly AS. Ovarian morpholgy and serum hormone markers as predictors of ovarian follicle recruiment by gonadotropins for in vitro fertilization. J Clin Endocrinol Metab 2001; 86: 2538- 2543. [DOI:10.1210/jcem.86.6.7605]
32. Fawzy M, Lambert A, Harrison RF, Knight PG, Groome N, Hennelly B, Robertson WR. Day 5 inhibin B levels in a treatment cycle are predictive of IVF outcome. Hum Reprod 2002; 17: 1535-1543. [DOI:10.1093/humrep/17.6.1535]
33. Lockwood G. The diagnostic value of Inhibin in infertility Evaluation. Semin Reprod Med 2004:22(3):195-208. [DOI:10.1055/s-2004-831895]
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