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Reproductive Biomedicine
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Volume 12, Issue 11 (12-2014)
IJRM 2014, 12(11): 747-0 |
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Yen M, Donma O, Yildizfer F, Ekmekci O, Kul A K, Imal A E, et al . Association of fetuin A, adiponectin, interleukin 10 and total antioxidant capacity with IVF outcomes. IJRM 2014; 12 (11) :747-0
URL: http://ijrm.ir/article-1-494-en.html
URL: http://ijrm.ir/article-1-494-en.html
Mustafa Yen1 
, Orkide Donma * 2, Ferdag Yildizfer1 , Ozlem Ekmekci1 , Asli Karatas Kul3 , A. Esat Imal1 , Zafer Keser1 , Emin Cagil1 , Murat Mengi1 , Hakan Ekmekci1 , Sezai Sahmay1 , Metin Donma4
, Orkide Donma * 2, Ferdag Yildizfer1 , Ozlem Ekmekci1 , Asli Karatas Kul3 , A. Esat Imal1 , Zafer Keser1 , Emin Cagil1 , Murat Mengi1 , Hakan Ekmekci1 , Sezai Sahmay1 , Metin Donma4
1- Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
2- Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey , odonma@gmail.com
3- Ministry of Health, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey
4- Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
2- Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey , odonma@gmail.com
3- Ministry of Health, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey
4- Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
Abstract: (2337 Views)
Background: Possible roles of anti-inflammatory factors as well as total antioxidative capacity in reproductive processes of women undergoing in vitro fertilization (IVF) are still being investigated and the contributions by some of them remain controversial.
Objective: The aim of this study is to investigate the relationship between anti-inflammatory parameters and total antioxidative capacity (TAC) of the body during IVF. In this respect, adiponectin, interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1RA), fetuin A and TAC analyses have been performed.
Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (Group-1), and 26 infertile women before (Group-2) and after (Group-3) IVF treatment were analyzed. IL-1RA, IL-10, fetuin A, adiponectin and insulin were determined by ELISA. TAC was determined spectrophotometrically. Mann-Whitney U test, paired sample t-test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis.
Results: Clinical pregnancy and live birth rates were determined as 30.8% and 23.1%, respectively, in pregnant group. For the pregnant, significant indirect correlations were detected between fetuin A and adiponectin (r=-0.843; p=0.035) as well as IL-10 (r=-0.846; p=0.034) in Group 2. The correlation between adiponectin and IL-10 doubled in pregnant compared to non-pregnant (r=0.929; p=0.007 vs. r=0.478; p=0.033). The correlations between fetuin A and TAC in pregnant were noted both in Group 2 (r=0.892; p=0.017) and Group 3 (r=0.875; p=0.022). No correlation of fetuin A with these parameters was detected in non-pregnant group.
Conclusion: Fetuin A, TAC, IL-10, adiponectin and their associations may be important from their predictive values for IVF success point of view. Parameters with anti-inflammatory or antioxidant property appear to improve pregnancy in women undergoing IVF.
Objective: The aim of this study is to investigate the relationship between anti-inflammatory parameters and total antioxidative capacity (TAC) of the body during IVF. In this respect, adiponectin, interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1RA), fetuin A and TAC analyses have been performed.
Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (Group-1), and 26 infertile women before (Group-2) and after (Group-3) IVF treatment were analyzed. IL-1RA, IL-10, fetuin A, adiponectin and insulin were determined by ELISA. TAC was determined spectrophotometrically. Mann-Whitney U test, paired sample t-test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis.
Results: Clinical pregnancy and live birth rates were determined as 30.8% and 23.1%, respectively, in pregnant group. For the pregnant, significant indirect correlations were detected between fetuin A and adiponectin (r=-0.843; p=0.035) as well as IL-10 (r=-0.846; p=0.034) in Group 2. The correlation between adiponectin and IL-10 doubled in pregnant compared to non-pregnant (r=0.929; p=0.007 vs. r=0.478; p=0.033). The correlations between fetuin A and TAC in pregnant were noted both in Group 2 (r=0.892; p=0.017) and Group 3 (r=0.875; p=0.022). No correlation of fetuin A with these parameters was detected in non-pregnant group.
Conclusion: Fetuin A, TAC, IL-10, adiponectin and their associations may be important from their predictive values for IVF success point of view. Parameters with anti-inflammatory or antioxidant property appear to improve pregnancy in women undergoing IVF.
Type of Study: Original Article |
References
1. Speroff L, Fritz MA. Clinical Gynecologic Endocrinology and Infertility. 7th Ed. Lippincott, Williams & Wilkins; 2005.
2. Mosalanejad L, Parandavar N, Gholami M, Abdollahifard S. Increasing and decreasing factors of hope in infertile women with failure in infertility treatment: A phenomenology study. Iran J Reprod Med 2014; 12: 117-124.
3. Hasanpoor-Azghdy SB, Simbar M, Abouali Vedadhir A. The emotional-psychological consequences of infertility among infertile women seeking treatment: Results of a qualitative study. Iran J Reprod Med 2014; 12: 131-138.
4. Yavuz A, Demirci O, Sözen H, Uludoğan M. Predictive factors influencing pregnancy rates after intrauterine insemination. Iran J Reprod Med 2013; 11: 227-234.
5. Lian HY, Gao Y, Jiao GZ, Sun MJ, Wu XF, Wang TY, et al. Antioxidant supplementation overcomes the deleterious effects of maternal restraint stress-induced oxidative stress on mouse oocytes. Reproduction 2013; 146: 559-568. [DOI:10.1530/REP-13-0268]
6. Younis A, Clower C, Nelsen D, Butler W, Carvalho A, Hok E, et al. The relationship between pregnancy and oxidative stress markers on patients undergoing ovarian stimulations. J Assist Reprod Genet 2012; 29: 1083-1089. [DOI:10.1007/s10815-012-9831-x]
7. Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility-a clinician's perspective. Reprod Biomed Online 2005; 11: 641-650. [DOI:10.1016/S1472-6483(10)61174-1]
8. Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG. Oxidative stress in an assisted reproductive techniques setting. Fertil Steril 2006; 86: 503-512. [DOI:10.1016/j.fertnstert.2006.02.088]
9. Chandra A, Surti N, Kesavan S, Agarwal A. Significance of oxidative stress in human reproduction. Arch Med Sci 2009; 5: S28-42.
10. Palini S, Benedetti S, Tagliamonte MC, De Stefani S, Primiterra M, Polli V, et al. Influence of ovarian stimulation for IVF/ICSI on the antioxidant defence system and relationship to outcome. Reprod Biomed Online 2014; 29: 65-71. [DOI:10.1016/j.rbmo.2014.03.010]
11. Showell MG, Brown J, Clarke J, Hart RJ. Antioxidants for female subfertility. Cochrane Database Syst Rev 2013; 8: CD007807.
12. Velthut A, Zilmer M, Zilmer K, Kaart T, Karro H, Salumets A. Elevated blood plasma antioxidant status is favourable for achieving IVF/ICSI pregnancy Reprod Biomed Online 2013; 26: 345-352.
13. Banerjee P, Ghosh S, Dutta M, Subramani E, Khalpada J, RoyChoudhury S, et al. Identification of key contributory factors responsible for vascular dysfunction in idiopathic recurrent spontaneous miscarriage. PLoS One 2013; 8: e80940.
14. Kumar A, Begum N, Prasad S, Agarwal S, Sharma S. IL-10, TNF-a & IFN-c: Potential early biomarkers for preeclampsia. Cell Immunol 2013; 283: 70-74. [DOI:10.1016/j.cellimm.2013.06.012]
15. Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, et al. The serum protein alpha 2-Heremans-Schmid glycoprotein/ fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 2003; 112: 357-366. [DOI:10.1172/JCI17202]
16. Bódis J, Peti AM, Sulyok E, Kovács GL, Várnagy A. Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization. Clin Chem Lab Med 2014; 52: 1313-1318. [DOI:10.1515/cclm-2014-0211]
17. Cankaya S, Demir B, Aksakal SE, Dilbaz B, Demirtas C, Goktolga U. Insulin resistance and its relationship with high molecule weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history. Fertil Steril 2014; 102: 826-830. [DOI:10.1016/j.fertnstert.2014.05.032]
18. Stefan N, Sun Q, Fritsche A, Machann J, Schick F, Gerst F, et al. Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of Type 2 diabetes: Prospective cohort- and cross-sectional phenotyping studies. PLoS One 2014; 9: e92238.
19. Jung CH, Kim BY, Kim CH, Kang SK, Jung SH, Mok JO. Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes. Diabete Vasc Dis Res 2013; 10: 459-467. [DOI:10.1177/1479164113490766]
20. Angelidis G, Dafopoulos K, Messini CI, Valotassiou V, Tsikouras P, Vrachnis N, et al. The emerging roles of adiponectin in female reproductive system-associated disorders and pregnancy. Reprod Sci 2013; 20: 872-881. [DOI:10.1177/1933719112468954]
21. Hung AM, Limkunakul C, Placido JS, Siew ED, Ellis CD, Shintani A, et al. Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients. J Nephrol 2014; In press.
22. Michalakis KG, Segars JH. The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction. Fertil Steril 2010; 94: 1949-1957. [DOI:10.1016/j.fertnstert.2010.05.010]
23. Richards JS, Liu Z, Kawai T, Tabata K, Watanabe H, Suresh D, et al. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility and early embryo development in the mouse and human. Fertil Steril 2012; 98: 471-479. [DOI:10.1016/j.fertnstert.2012.04.050]
24. Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 1998; 16: 27-55. [DOI:10.1146/annurev.immunol.16.1.27]
25. Baker VL, Jones CE, Cometti B, Hoehler F, Salle B, Urbancsek J, et al. Factors affecting success rates in two concurrent clinical IVF trials: an examination of potential explanations for the difference in pregnancy rates between the United States and Europe. Fertil Steril 2010; 94: 1287-1291. [DOI:10.1016/j.fertnstert.2009.07.1673]
26. Cetin MT, Kumtepe Y, Kiran H, Seydaoglu G. Factors affecting pregnancy in IVF: age and duration of embryo transfer. Reprod Biomed Online 2010; 20: 380-386. [DOI:10.1016/j.rbmo.2009.12.008]
27. Fanaei H, Khayat S, Halvaei I, Ramezani V, Azizi Y, Kasaeian A, et al. Effects of ascorbic acid on sperm motility, viability, acrosome reaction and DNA integrity in teratozoospermic samples. Iran J Reprod Med 2014; 12: 103-110.
28. Smith ER, Ford ML, Tomlinson LA, Rocks BF, Rajkumar C, Holt SG. Poor agreement between commercial ELISAs for plasma fetuin A: An effect of protein glycosylation? Clin Chim Acta 2010; 411: 1367-1370.
29. Smith ER, Holt SG. Important differences in measurement of fetuin A. Ann Intern Med 2010; 153: 419. [DOI:10.7326/0003-4819-153-6-201009210-00016]
30. Bilgir O, Kebapcilar L, Bilgir F, Bozkaya G, Yildiz Y, Pinar P, et al. Decreased serum fetuin A levels are associated with coronary artery diseases. Intern Med 2010; 49: 1281-1285. [DOI:10.2169/internalmedicine.49.3223]
31. Kebapcilar L, Bilgir O, Cetinkaya E, Akyol M, Bilgir F, Bozkaya G. The effect of helicobacter pylori eradication on macrophage migration inhibitory factor, C-reactive protein and fetuin A levels. Clinics (Sao Paulo) 2010; 65: 799-802. [DOI:10.1590/S1807-59322010000800010]
32. Balon BP, Knehtl M, Bevc S, Jakopin E, Gorenjak M. Fetuin A as a risk factor for mortality in hemodialysis patients. Wien Klin Wochenschr 2010; 122: S63-67.
33. Kalabay L, Cseh K, Pajor A, Baranyi E, Csákány GM, Melczer Z, et al. Correlation of maternal serum fetuin α2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. Eur J Endocrinol 2002; 147: 243-248. [DOI:10.1530/eje.0.1470243]
34. Wang H, Sama AE. Anti-inflammatory role of fetuin-A in injury and infection. Curr Mol Med 2012; 12: 625-633. [DOI:10.2174/156652412800620039]
35. Li W, Zhu S, Li J, Huang Y, Zhou R, Fan X, et al. A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation. PLoS One 2011; 6: e16945.
36. Iliodromiti S, Vracnis N, Samoli E, Iliodromiti Z, Pangalos C, Drakoulis N, et al. Fetuin A concentration in the second trimester amniotic fluid of fetuses with trisomy 21 appears to be lower: phenotypic considerations. Mediators Inflamm 2012; 2012: 138971. [DOI:10.1155/2012/138971]
37. Molvarec A, Kalabay L, Derzsy Z, Szarka A, Halmos A, Stenczer B, et al. Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein (fetuin-A) concentration. Hypertens Res 2009; 32: 665-669. [DOI:10.1038/hr.2009.79]
38. Karamessinis PM, Malamitsi-Puchner A, Boutsikou T, Makridakis M, Vougas K, Fountoulakis M, et al. Marked defects in the expression and glycosylation of α-2-HS glycoprotein/Fetuin-A in plasma from neonates with intrauterine growth restriction. Mol Cell Proteomics 2008; 7: 591-599. [DOI:10.1074/mcp.M700422-MCP200]
39. Ishibashi A, Ikeda Y, Ohguro T, Kumon Y, Yamanaka S, Takata H, et al. Serum fetuin-A is an independent marker of insulin resistance in Japanese men. J Atheroscler Thromb 2010; 17: 925-933. [DOI:10.5551/jat.3830]
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