Volume 12, Issue 2 (2-2014)                   IJRM 2014, 12(2): 151-154 | Back to browse issues page

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Habibi M, Bahrami A, Morteza A, Sadighi Gilani M A, Hassanzadeh G, Ghadami M et al . Study of cytomegalovirus infection in idiopathic infertility men referred to Shariati hospital, Tehran, Iran. IJRM 2014; 12 (2) :151-154
URL: http://ijrm.ir/article-1-508-en.html
Study of cytomegalovirus infection in idiopathic infertility men referred to Shariati hospital, Tehran, Iran
Masoud Habibi1 , Alireza Bahrami1 , Afsaneh Morteza2 , Mohammad Ali Sadighi Gilani3 , Gholamreza Hassanzadeh4 , Mohsen Ghadami5 , Hamid Choobineh * 6
1- Iranian Center for Breast Cancer, Academic Center for Education Culture and Research (ACECR), Tehran, Iran
2- Tehran University of Medical Sciences, Tehran, Iran
3- Department of Urology, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Anatomy and Reproductive Biology, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Medical Genetics, Endocrine and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
6- School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran , hchobineh@tums.ac.ir
Abstract:   (3469 Views)
Background: Cytomegalovirus (CMV) is a prevalent infection in humans. Recent studies have shown the role of CMV infection in male infertility disorder.
Aim: Here we aimed to study the role of CMV infection in men with idiopathic infertility.
Materials and Methods: We performed a case-control study of CMV serology in 200 patients attending male infertility clinic of a university hospital. There were 154 men diagnosed with infertility and 46 men without infertility. The patients were asked to donate their sperm, blood, and urine. The presence of CMV infection was studied using quantitative polymerase chain reaction.
Results: CMV infection was present in 25 of all the studied participants. Controls had a higher sperm count and sperm motility and sperm morphology compared to patients. There were no significant differences in the studied variables between those with and without CMV infection, nor in patients, neither in controls. Sperm morphology was negatively correlated with cigarette smoking (r=-0.15; p<0.03). Even though the prevalence of CMV infection was higher in patients with infertility in control and patient (5/46 vs. 20/154) respectively, this was not statistically significant.
Conclusion: We did not show a significant role for CMV infection in male infertility. Based on the previous studies, it could be assumed that CMV infection is an important part of the male infertility and its treatment would improve the sperm quality, however this was not confirmed by the present study.
Keywords: Male infertility, Cytomegalovirus infection, Sperm morphology
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Type of Study: Original Article |
References
1. Hirsh A. Male subfertility. BMJ 2003; 327: 669-672. [DOI:10.1136/bmj.327.7416.669]
2. Baker HW. Medical treatment for idiopathic male infertility: is it curative or palliative? Baillieres Clin Obstet Gynaecol 1997; 11: 673-689. [DOI:10.1016/S0950-3552(97)80006-5]
3. DeMasters J. Male factor infertility: an overview of issues. Adv Nurse Pract 2004; 12: 20-26.
4. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16: 231-245. [DOI:10.1093/humupd/dmp048]
5. Eggert-Kruse W, Reuland M, Johannsen W, Strowitzki T, Schlehofer JR. Cytomegalovirus (CMV) infection-related to male and/or female infertility factors? Fertil Steril 2009; 91: 67-82. [DOI:10.1016/j.fertnstert.2007.11.014]
6. Krause W, Herbstreit F, Slenzka W. Are viral infections the cause of leukocytospermia? Andrologia 2002; 34: 87-90. [DOI:10.1046/j.0303-4569.2001.00484.x]
7. Erles K, Rohde V, Thaele M, Roth S, Edler L, Schlehofer JR. DNA of adeno-associated virus (AAV) in testicular tissue and in abnormal semen samples. Hum Reprod 2001; 16: 2333-2337. [DOI:10.1093/humrep/16.11.2333]
8. Greil AL, Slauson-Blevins K, McQuillan J. The experience of infertility: A review of recent literature. Socio Health Illn 2010; 32: 140-162. [DOI:10.1111/j.1467-9566.2009.01213.x]
9. Behzad-Behbahani A, Entezam M, Mojiri A, Pouransari R, Rahsaz M, Banihashemi M, et al. Incidence of human herpes virus-6 and human cytomegalovirus infections in donated bone marrow and umbilical cord blood hematopoietic stem cells. Indian J Med Microbiol 2008; 26: 252-255. [DOI:10.4103/0255-0857.42038]
10. Ziyaeyan M, Sabahi F, Alborzi A, Mahboudi F, Kazemnejad A, Ramzi M, et al. Diagnosis and monitoring of human cytomegalovirus infection in bone marrow transplant recipients by quantitative competitive PCR. Exp Clin Transplant 2006; 4: 470-474.
11. Nigro G, Mazzocco M, Aragona C, D'Emilio C, Cosmi EV. Hyperimmunoglobulin therapy for cytomegalovirus-associated infertility: case reports. Fertil Steril 2000; 74: 830-831. [DOI:10.1016/S0015-0282(00)01521-1]
12. Csata S, Kulcsar G. Virus-host studies in human seminal and mouse testicular cells. Acta Chir Hung 1991; 32: 83-90.
13. Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 2007; 87: 1087-1097. [DOI:10.1016/j.fertnstert.2006.08.109]
14. Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 2007; 87: 1087-1097. [DOI:10.1016/j.fertnstert.2006.08.109]
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