Volume 12, Issue 5 (6-2014)                   IJRM 2014, 12(5): 321-0 | Back to browse issues page

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Masihi S, Barati M, Mohamadjafari R, Hashemi M. Assessemnt of nasal bone in first trimester screening for chromosomal abnormalities in Khuzestan. IJRM 2014; 12 (5) :321-0
URL: http://ijrm.ir/article-1-539-en.html
Assessemnt of nasal bone in first trimester screening for chromosomal abnormalities in Khuzestan
Sara Masihi * 1, Mojgan Barati2 , Razieh Mohamadjafari2 , Marzieh Hashemi3
1- Depatment of Obstetric and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , sara.masihi@yahoo.com
2- Depatment of Obstetric and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
3- Department of obstetrics and Gynecology, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
Abstract:   (18905 Views)
Background: Fetal nasal bone assessment is a non-invasive procedure that helps provide even greater assurance to patients undergoing their first trimester risk assessment for aneuploidies. Absence or presence of this factor is different in some races.
Objective: The study was aimed to evaluate nasal bone in the first trimester of pregnancy in the indigenous population of Khuzestan Province, and to monitor its value in the diagnosis of chromosomal abnormalities.
Materials and Methods: This study was conducted on 2314 pregnant women between 17-43 years old who referred for first trimester screening for chromosomal abnormalities. Gestational age was between 11-13w + 6 days. Nuchal translucency (NT), fetal heart rate (FHR), crown rump length (CRL), and maternal age and maternal blood serum factors (Free βHCG) and pregnancy-associated plasma protein-A (PAPP-A) and nasal bone were assessed. Finally the risk of trisomies was calculated. The statistical tests are based on the relationship between chromosomal abnormality and the presence or absence of the nasal bone.
Results: In 114 cases we could not examine the nasal bone. Also, in 20 cases missed abortion happened without knowing the karyotype. 2173 cases were delivered normal baby, and in seven cases chromosomal abnormalities were diagnosed. Nasal bone was absent in all three cases with trisomy 21 and six of 2173 cases with normal phenotype (0.3%). With use of the Fisher exact test (p=0.0001), a significant correlation was found between the absence of the nasal bone and the risk of chromosomal abnormality.
Conclusion: Inclusion of the nasal bone in first-trimester combined screening for aneuploidies achieves greater detection rate especially in Down syndrome
Keywords: Prenatal diagnosis, Nuchal translucency measurement, Maternal serum screening test, Nasal bone
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Type of Study: Original Article |
References
1. Adzick NS, Harrison MR, Cunningham F, Levavano J. Williams's obstetrics. 23PthP Ed. New York, MC Graw Hill; 2010: 287-311.
2. Bindra R, Heath V, Liao A, Spencer K, Nicolaides KH. One stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: A prospective study of 15030 pregnancies. Ultrasound Obstet Gynecol 2002; 20: 219-225. [DOI:10.1046/j.1469-0705.2002.00808.x]
3. Nicolaides KH. Screening for fetal aneuploidies at 11-13 weeks. Prenat Diagn 2011; 31: 7-15. [DOI:10.1002/pd.2637]
4. Mogra R, Schluter PJ, Ogle RF, O'Connell J, Fortus L, Hyett JA. A prospective cross-sectional study to define racial variation in fetal Nasal bone length through ultrasound assessment at 11-13 weeks' gestation. Aust N Z J Obstet Gynaecol 2010; 50: 528-533. [DOI:10.1111/j.1479-828X.2010.01226.x]
5. Ozer A, Ozaksit G, Kanat Pektas M, Ozers: First trimester examination of fetal Nasal bone in the Turkish population. J Obstet Gynaecol Res 2010; 36: 739-744. [DOI:10.1111/j.1447-0756.2010.01182.x]
6. 58TKagan KO58T, 58TCicero S58T, 58TStaboulidou I58T, 58TWright D58T, 58TNicolaides KH58T. Fetal Nasal bone in screening for trisomies 21, 18 and 13 and turner syndrome at 11-13 weeks of gestation. Ultrasound Obstet Gynecol 2009; 33: 259-264. [DOI:10.1002/uog.6318]
7. 58TBunduki V58T, 58TRuano R58T, 58TMiguelez J58T, 58TYoshizaki CT58T, 58TKahhale S58T, 58TZugaib M58T. Fetal nasal bone length: reference range and clinical application in ultrasound screening for trisomy 21. Ultrasound Obstet Gynecol 2003; 21: 156-160. [DOI:10.1002/uog.31]
8. 58TYeo GS58T, 58TLai FM58T, 58TWei X58T, 58TLata P58T, 58TTan DT58T, 58TYong MH58T, et al. Validation of first trimester screening for trisomy21 in Singapore with reference to performance of nasal bone. Fetal Diagn Ther 2012; 32: 166-170. [DOI:10.1159/000338656]
9. 58TGhaffari SR58T, 58TTahmasebpour AR58T, 58TJamal A58T, 58THantoushzadeh S58T, 58TEslamian L58T, 58TMarsoosi V58T, et al. First-trimester screening for chromosomal abnormalities by integrated application of nuchal translucency, nasal bone, tricuspid regurgitation and ductus venosus flow combined with maternal serum free βhCG and PAPP-A: a 5-year prospective study. Ultrasound Obstet Gynecol 2012; 39: 528-534. [DOI:10.1002/uog.10051]
10. Nicolaides KH. Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol 2004; 191: 45-67. [DOI:10.1016/j.ajog.2004.03.090]
11. Nicolaides KH. Screening for chromosomal defects. Ultrasound Obstet Gynecol 2003; 21: 313-321. [DOI:10.1002/uog.128]
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