Volume 12, Issue 6 (8-2014)                   IJRM 2014, 12(6): 415-0 | Back to browse issues page

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Zolghadri J, Haghbin H, Dadras N, Behdin S. Vagifem is superior to vaginal Premarin in induction of endometrial thickness in the frozen-thawed cycle patients with refractory endometria: A randomized clinical trial. IJRM 2014; 12 (6) :415-0
URL: http://ijrm.ir/article-1-553-en.html
Vagifem is superior to vaginal Premarin in induction of endometrial thickness in the frozen-thawed cycle patients with refractory endometria: A randomized clinical trial
Jaleh Zolghadri1 , Hossein Haghbin * 2, Nasrin Dadras1 , Shabnam Behdin1
1- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , hoshaq@yahoo.com
Abstract:   (5070 Views)
Background: Embryo transfer to a developed endometrium is an important prognostic factor in frozen-thawed embryo transfer cycle outcome. Vaginal estrogen, such as Vagifem vaginal tablets and Premarin vaginal cream, is a regimen used for the patients with refractive endometria. Objective: Our objective was to compare the effects of Vagifem and Premarin on the endometrial thickness of the patients with refractive endometria. Materials and Methods: In this randomized clinical trial, 30 patients with refractive endometria in frozen-thawed embryo transfer cycles received Vagifem vaginal tablets and 30 women received Premarin vaginal cream. Endometrial thickness was measured on the 14th day of drug administration. Results: Comparing the endometrial thicknesses of the two groups showed that the endometria of the Vagifem group was significantly thicker than that of the Premarin group (5.93±0.38 vs. 6.74±0.32; p<0.001). Conclusion: Vagifem is superior to Premarin in induction of endometrial thickness in frozen-thawed embryo transfer cycles in the patients with refractive endometria.
Keywords: Premarin, Estradiol, Endometrium, Infertility, Human
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Type of Study: Original Article |
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