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Reproductive Biomedicine
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Volume 12, Issue 7 (8-2014)
IJRM 2014, 12(7): 467-0 |
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Safdarian L, Najmi Z, Aleyasin A, Aghahosseini M, Rashidi M, Asadollah S. Recurrent IVF failure and hereditary thrombophilia. IJRM 2014; 12 (7) :467-0
URL: http://ijrm.ir/article-1-563-en.html
URL: http://ijrm.ir/article-1-563-en.html
Leila Safdarian1 
, Zahra Najmi2 , Ashraf Aleyasin1 , Marzieh Aghahosseini1 , Mandana Rashidi * 3, Sara Asadollah2
, Zahra Najmi2 , Ashraf Aleyasin1 , Marzieh Aghahosseini1 , Mandana Rashidi * 3, Sara Asadollah2
1- Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
3- Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran , rashidy_mandana@yahoo.com
2- Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
3- Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran , rashidy_mandana@yahoo.com
Abstract: (2545 Views)
Background: The largest percentage of failed invitro fertilization (IVF) cycles, are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure.
Objective: Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures.
Materials and Methods: Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups.
Results: Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI=1.74-5.70, OR=3.15, p=0.00). Mutation of factor V Leiden (95% CI=1.26-10.27, OR=3.06, P=0.01) and homozygote form of MTHFR mutation (95% CI=1.55-97.86, OR=12.33, p=0.05) were also risk factors for recurrent IVF failure. However, we could not find significant difference in other inherited thrombophilia’s.
Conclusion: Inherited thrombophilia is more prevalent in women with recurrent IVF failure compared with healthy women. Having at least one thrombophilia, mutation of factor V Leiden and homozygote form of MTHFR mutation were risk factors for recurrent IVF failure.
Objective: Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures.
Materials and Methods: Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups.
Results: Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI=1.74-5.70, OR=3.15, p=0.00). Mutation of factor V Leiden (95% CI=1.26-10.27, OR=3.06, P=0.01) and homozygote form of MTHFR mutation (95% CI=1.55-97.86, OR=12.33, p=0.05) were also risk factors for recurrent IVF failure. However, we could not find significant difference in other inherited thrombophilia’s.
Conclusion: Inherited thrombophilia is more prevalent in women with recurrent IVF failure compared with healthy women. Having at least one thrombophilia, mutation of factor V Leiden and homozygote form of MTHFR mutation were risk factors for recurrent IVF failure.
Type of Study: Original Article |
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