Volume 5, Issue 2 (7-2007)                   IJRM 2007, 5(2): 13-16 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Montaserti A, Pourheydar M, Khazaei M, Ghorbani R. Anti-fertility effects of physalis alkekengi alcoholic extract in female rat. IJRM 2007; 5 (2) :13-16
URL: http://ijrm.ir/article-1-62-en.html
1- Reproduction Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran , Montaseri_azi@yahoo.com
2- Reproduction Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (2425 Views)
Background: Physalis alkekengi (P. alkekengi)has been used as an abortive plant in Iranian traditional medicine for many years.
Objective: To investigate the effects of P.alkekengi on the fertility rate in female rats.
Material and Methods: In this experimental study, 40 female albino rats were divided randomly into two groups; group 1/for investigating the implantation sites and group 2/ for investigating the number and weight of neonates. In both groups, treated animals received plant extract at dose of 150 mg/kg on days 1-5 of pregnancy. In group 1, treated animals were euthanized at 7th days of pregnancy and number of implantation sites were counted. In group 2, treated animals maintained till delivery time and after delivery, the number and weight of neonates were investigated.
Results: Data showed that administration of P. alkekengi extract on days 1-5 of pregnancy significantly decreased the number of implantation sites, number and weight of neonates.
Conclusion: These results suggest that the extract produced anti- fertility effect probably by inhibiting implantation.
Full-Text [PDF 42 kb]   (792 Downloads) |   |   Full-Text (HTML)  (323 Views)  
Type of Study: Original Article |

1. Amini A. Dictionary of therapeutic plants. Tehran University, Tehran, 2004; 157-159.
2. Zargari A. Medical plants. Tehran University, Tehran, 2003; 3595-3596.
3. Heber D. Herbal medicine. 2005; 3: 885.
4. Duke JA. Handbook of Medicinal herbs, 2002; 2: 787-788. [DOI:10.1201/9781420040463]
5. Mirheydar H. Herbal information: usage of plants in prevention and treatment of diseases. 2003; 5: 39-42.
6. Bown D. Encyclopedia of herbs and their uses. 2002: 313-314.
7. Henshaw SK. Unintended pregnancies in United States. Fam plan prespect 1998; 30: 24-29. [DOI:10.2307/2991522]
8. Dehghan M, Martin T, Dehghanan R. Anti-fertility effect of Iranian neem seed alcoholic extract on epididymal sperm of mice. IJRM 2005; 3: 83-89.
9. Dixit VP. Plant products/non-steroidal compounds affecting fertility in the Indian desert gerbil, Merions hurrianae jerdon. In: Parkash I & Ghosh PK (editor), Rodents in Indian Agriculture. Scientific publishers. Jodhpur, India 1992; 1: 595-604.
10. Vessal M, Yazdanian M. Comparison of the effects of an aqueous extract of Physalis alkekengi fruits and/or various doses of 17-beta-estradiol on rat estrous cycle and uterine glucose 6-phosphate dehydrogenase activity. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1995; 112: 229-236. [DOI:10.1016/0742-8413(95)02014-4]
11. Vessal M, Rasti M, Kooshesh F. Modulation of the pituitary and basomedial hypothalamic lysyl-aminopeptidase activities be beta-estradiol and/or an aqueous extract of Physalis alkekengi fruits. Comp Biochem Physiol B Biochem Mol Biol 1996; 115: 267-271. [DOI:10.1016/0305-0491(96)00078-8]
12. Gebri E, Makonnen E, Zerihun L, Debella A. The possible mechanisms for the antifertility action of methanolic root extract of Rumex studelii. Afr Health Sci 2005; 5: 119-125.
13. Nivsarkar M, Patel M, Padh H, Bapu C, Shrivastava N. Blastocyst implantation failure in mice due to "nonreceptive endometrium": endometrial alterations by Hibiscus rosa-sinesisleaf extract. Contraception 2005; 71: 227-230. [DOI:10.1016/j.contraception.2004.10.004]
14. Kulkarni TR, kothekar MA, Matheenuddin M. Study of anti-fertility effect of lemon seedas (Citrus limonum) in female albino mice. Indian J Phisiol Pharmacol 2005; 49: 305-312.
15. WHO: protocol CG-04. Preparation of alcoholic extract for bioassay and phytochemical studies (APJF/IP, 1001A). Geneva, World Health Organization 1983a.
16. Miller LC, Tainter ML. Estimation of ED50 and its error by means of log probit graph. Proceedings of the Society of Experimental Biology and Medicine 1944; 57: 261-264. [DOI:10.3181/00379727-57-14776]
17. Vessal M. Mehrani HA, Omrani GH. Effects of an aqueous extract of Physalis alkekengi fruit on estrus cycle, reproduction and uterine creatine kinase BB-isozyme in rats. J Ethnopharmacol 1991; 34: 69-78. [DOI:10.1016/0378-8741(91)90190-O]

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb