Volume 13, Issue 5 (7-2015)                   IJRM 2015, 13(5): 263-268 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Beltadze K, Barbakadze L. Ovarian reserve in women of late reproductive age by the method of treatment of PCOS. IJRM 2015; 13 (5) :263-268
URL: http://ijrm.ir/article-1-651-en.html
Ovarian reserve in women of late reproductive age by the method of treatment of PCOS
Ketevan Beltadze * 1, Ludmila Barbakadze2
1- Department of Reproductology, Obstetrics and Gynecology, Medical Faculty, I. Javakhishvili Tbilisi State University, Tbilisi, Georgia , ketevan.beltadze@med.tsu.edu.ge
2- Department of Reproductology, Obstetrics and Gynecology, Medical Faculty, I. Javakhishvili Tbilisi State University, Tbilisi, Georgia
Abstract:   (7801 Views)
Background: The prevalence of polycystic ovarian syndrome (PCOS) particularly is increased in adolescents. Very few longitudinal follow-up for assessment of ovarian reserve in women of late reproductive age with previously confirmed PCOS have been conducted, especially after its diagnosis and treatment in adolescence.
Objective: The aim of the present study was to compare of the ovarian reserve of the women of late reproductive age by the method of treatment of PCOS in adolescence.
Materials and Methods: This cross sectional study in an unselected population was conducted from January to June 2014. A total of 123 women of late reproductive age were included. They had been diagnosed with PCOS between 1984 and 1990 when they were 13-18 yr. From these, first group of the study was consisted of 67 participants who underwent conservative treatment with antiandrogens and combined oral contraceptives and second group of the study was consisted of 56 participants after surgery (34-bilateral ovarian drilling and 22- ovarian wedge resection). At the time of investigation patients were 35-45 yr. The participants were collected via analysis of histories at primary diagnosis of PCOS in adolescence and at the time of the investigation analyses of reproductive hormones were conducted. Data were compared between the groups.
Results: After conservative treatment PCOS women had higher levels of anti- mullerian hormone and lower follicle-stimulating hormone levels (p=0.02 and p=0.04, respectively). The number of antral follicles and mean ovarian volume were significantly greater also, than in women who underwent surgical treatment (p=0.03 and p=0.04, respectively).
Conclusion: Our data suggest that PCOS patients who underwent conservative treatment have the better ovarian reserve than women who underwent surgical treatment of PCOS in adolescence.
Keywords: Polycystic ovarian syndrome, Ovarian reserve, Anti-mullerian hormone.
Full-Text [PDF 209 kb]   (716 Downloads) |   |   Full-Text (HTML)  (395 Views)  
Type of Study: Original Article |
References
1. Chie T, Atsuy F, Masahiro K, Rie S, Hiroe I, Keiichi I. Anti-Mullerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization. Fertil Steril 2008; 89: 586-591. [DOI:10.1016/j.fertnstert.2007.03.080]
2. Mashiach R, Amit A, Hasson J, Amzalzg S, Ben-Yosef B, Lessin J, et al. Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome. Fertil Steril 2010; 93: 2299-2302. [DOI:10.1016/j.fertnstert.2009.01.125]
3. Maheshwari A, Gibreel A, Bhattacharya S, Johnson N. Dynamic tests of ovarian reserve: a systematic review of diagnostic accuracy. Reprod Biol Med 2009; 18: 717-734. [DOI:10.1016/S1472-6483(10)60019-3]
4. Barad DH, Weghofer A, Gleicher N. Comparing anti-Mullerian Hormone (AMH) and Follicle-Stimulating Hormone (FSH) as predictors of ovarian function. Fertil Steril 2009; 91: 1553-1555. [DOI:10.1016/j.fertnstert.2008.09.069]
5. Fiçiciog C, Kutlu T, Baglam E and Bakacak Z. Early follicular anti-müllerian hormone as an indicator of ovarian reserve. Fertil Steril 2006; 85: 592-596. [DOI:10.1016/j.fertnstert.2005.09.019]
6. Chang H, Hoon Han S, Ryeol Lee J, Chul Jee B, Ick Lee B, Chang Suk S, et al. Impact of laparoscopic cystectomy on ovarian reserve: serial changes of serum anti-mullerian hormone levels. Fertil Steril 2010; 94: 343-349. [DOI:10.1016/j.fertnstert.2009.02.022]
7. Moran LJ, Hutchison SK, Norman RJ, Teede HJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev 2011; 7: CD007506. [DOI:10.1002/14651858.CD007506.pub3]
8. Hassan A, Gordon CM. Polycystic ovary syndrome update in adolescence. Curr Opin Pediatr 2007; 19: 389-397. [DOI:10.1097/MOP.0b013e328236743f]
9. Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS). Fertil Steril 2012; 97: 28-38. [DOI:10.1016/j.fertnstert.2011.09.024]
10. Visser JA, de Jong FH, Laven JS, Themmen AP. Anti-Müllerian hormone: a new marker for ovarian function. Reproduction 2006; 131: 1-9. [DOI:10.1530/rep.1.00529]
11. Fernandez H, Morin-Surruca M, Torre A, Faivre E, Deffieux X, Gervaise A. Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review. Reprod Biol Med 2011; 22: 556-558. [DOI:10.1016/j.rbmo.2011.03.013]
12. Fauser B, Tarlatzis B, Chang J, Azziz R, Legro R, Dewailly D, et al. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41-47. [DOI:10.1093/humrep/deh098]
13. Dumesic D, Padmanabhan V, Abott D. Polycystic ovary syndrome and oocyte developmental competence. Obstet Gynecol Surv 2008; 63: 39-48. [DOI:10.1097/OGX.0b013e31815e85fc]
14. Sowers M, McConnell D, Zheng H, Nan B, McCar J, Randolph J. Anti-Mullerian hormone and inhibin B variability during normal menstrual cycles. Fertil Steril 2010; 94: 1482-1486. [DOI:10.1016/j.fertnstert.2009.07.1674]
15. Amer S, Li TC, Ledger WL. The value of measuring anti-Mullerian hormone in women with an ovulatory polycystic ovary syndrome undergoing laparoscopic ovarian diathermy. Hum Reprod 2009; 24: 2760-2766. [DOI:10.1093/humrep/dep271]
16. Weerakiet S, Lertvikool S, Tingthanatikul Y, Wansumrith S, Leelaphiwat S, Jultanmas R. Ovarian reserve in women with polycystic ovary syndrome who underwent laparoscopic ovarian drilling. Gynecol Endocrinol 2007; 23: 455-460. [DOI:10.1080/09513590701485212]
17. Elmashad Al. Impact of laparoscopic ovarian drilling on anti-Mullerian hormone levels and ovarian stromal blood flow using three-dimensional power Doppler in women with anovulatory polycystic ovary syndrome. Fertil Steril 2011; 95: 2342-2346. [DOI:10.1016/j.fertnstert.2011.03.093]
18. Franks S, Stark J, Hardy K. Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update 2008; 14: 367-378. [DOI:10.1093/humupd/dmn015]
19. Farquhar C, Brown J, Marjoribanks J. Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev 2012; 6: CD001122. [DOI:10.1002/14651858.CD001122.pub4]
20. Hudecova M, Holte J, Olovsson M, SundströmPoromaa I. Long-term follow-up of patients with polycystic ovary syndrome: reproductive outcome and ovarian reserve. Hum Reprod 2009; 24: 1176-1183. [DOI:10.1093/humrep/den482]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb