Volume 13, Issue 6 (8-2015)                   IJRM 2015, 13(6): 355-360 | Back to browse issues page

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Khooshideh M, Radi V, Hosseini R, Hosseini L. The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes. IJRM 2015; 13 (6) :355-360
URL: http://ijrm.ir/article-1-658-en.html
The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes
Maryam Khooshideh1 , Vida Radi1 , Reihaneh Hosseini * 2, Ladan Hosseini3
1- Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran , rayh_h@yahoo.com
3- Research Development Center, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (2763 Views)
Background: Premature rupture of membranes (PROM) is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. Therefore, an appropriate diagnosis and management of PROM are of significant importance in patients.
Objective: The aim of this study was to determine the accuracy of placental alpha microglobuline-1 (PAMG-1) test in PROM diagnosis and compare this diagnostic method with other standard tests in diagnosis of PROM.
Materials and Methods: In this prospective diagnostic accuracy study, patients with symptoms of membrane rupture in 16-39 weeks of gestation were involved. Three tests including Fern, Nitrazine and PAMG-1 were performed at the same time.
Results: PROM was confirmed in 86 patients out of 100. The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test. PAMG-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests. Although PAMG-1showed a lower positive predictive value (PPV) compared to conventional tests such as Fern test (100%), it was shown to be more accurate.
Conclusion: The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis.
Keywords: Placental alpha microglobulin-1, Premature ruptures of membrane, Diagnostic test
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Type of Study: Original Article |
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