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Reproductive Biomedicine
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Volume 13, Issue 6 (8-2015)
IJRM 2015, 13(6): 361-366 |
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Farzadi L, Khayatzadeh Bidgoli H, Ghojazadeh M, Bahrami Z, Fattahi A, Latifi Z, et al . Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. IJRM 2015; 13 (6) :361-366
URL: http://ijrm.ir/article-1-659-en.html
URL: http://ijrm.ir/article-1-659-en.html
Laya Farzadi1 
, Homa Khayatzadeh Bidgoli1 , Morteza Ghojazadeh2 , Zahra Bahrami1 , Amir Fattahi3 , Zeinab Latifi3 , Vahideh Shahnazi1 , Mohammad Nouri * 4
, Homa Khayatzadeh Bidgoli1 , Morteza Ghojazadeh2 , Zahra Bahrami1 , Amir Fattahi3 , Zeinab Latifi3 , Vahideh Shahnazi1 , Mohammad Nouri * 4
1- Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Clinical Biochemistry, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4- Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,nourimd@yahoo.com
2- Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Clinical Biochemistry, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4- Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract: (2969 Views)
Background: Vitamin D in complex with its receptor by regulating gene expression, endometrium immune response and stimulation of endometrium decidualization can be involved in implantation. So, it seems that the amount of vitamin D in follicular fluids (FF) may have an association with ART success.
Objective: First, we intended to investigate the possible association between levels of follicular fluids 25-OH vitamin D with assisted reproductive outcomes. Second, we examined relationship between 25-OH vitamin D levels with number and quality of oocytes.
Materials and Methods: In a prospective study, 80 infertile female candidates for IVF/ICSI were enrolled. Blood samples (on the day of human chorionic gonadotropin administration) and follicular fluids were taken, and then levels of serum estradiol and follicular fluids 25-OH vitamin D were measured. Also clinical characteristics of patients (duration of infertility, causes of infertility, menstrual status), number and quality of oocytes, number of fertilized oocytes, estradiol levels, and clinical pregnancy were evaluated.
Results: Concentration of FF 25-OH vitamin D in pregnant women was significantly higher than non-pregnant women (p=0.007) but there were no significant differences in age, body mass index (BMI), duration of infertility, menstrual status, number of oocytes, oocytes quality, number of fertilized oocytes, and serum estradiol levels between the two groups. Statistically positive correlation was found between 25-OH vitamin D levels with patient age and implantation rate (r=0.264, p=0.018 and r=0.301, p=0.007 respectively).
Conclusion: The obtained results suggest that vitamin D without affecting the number and quality of oocytes can independently improve implantation rate and IVF outcome.
Objective: First, we intended to investigate the possible association between levels of follicular fluids 25-OH vitamin D with assisted reproductive outcomes. Second, we examined relationship between 25-OH vitamin D levels with number and quality of oocytes.
Materials and Methods: In a prospective study, 80 infertile female candidates for IVF/ICSI were enrolled. Blood samples (on the day of human chorionic gonadotropin administration) and follicular fluids were taken, and then levels of serum estradiol and follicular fluids 25-OH vitamin D were measured. Also clinical characteristics of patients (duration of infertility, causes of infertility, menstrual status), number and quality of oocytes, number of fertilized oocytes, estradiol levels, and clinical pregnancy were evaluated.
Results: Concentration of FF 25-OH vitamin D in pregnant women was significantly higher than non-pregnant women (p=0.007) but there were no significant differences in age, body mass index (BMI), duration of infertility, menstrual status, number of oocytes, oocytes quality, number of fertilized oocytes, and serum estradiol levels between the two groups. Statistically positive correlation was found between 25-OH vitamin D levels with patient age and implantation rate (r=0.264, p=0.018 and r=0.301, p=0.007 respectively).
Conclusion: The obtained results suggest that vitamin D without affecting the number and quality of oocytes can independently improve implantation rate and IVF outcome.
Type of Study: Original Article |
References
1. Shahbazi M, Jeddi-Tehrani M, Zareie M, Salek-Moghaddam A, Akhondi M, Bahmanpoor M, et al. Expression profiling of vitamin D receptor in placenta, decidua and ovary of pregnant mice. Placenta 2011; 32: 657-664. [DOI:10.1016/j.placenta.2011.06.013]
2. Kramer CK, Swaminathan B, Hanley AJ, Connelly PW, Sermer M, Zinman B, et al. Vitamin D and Parathyroid Hormone Status in Pregnancy: Impact on Insulin Sensitivity, Beta-cell Function, and Gestational Diabetes Mellitus. J Clin Endocrinol Metab 2014; 99: 4506-4513. [DOI:10.1210/jc.2014-2341]
3. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 2008; 3: e3753. [DOI:10.1371/journal.pone.0003753]
4. Abdi J, Redinger D, Broughton KS. Plasma vitamin D level among women with and without polycystic ovarian syndrome. FASEB J 2013; 27: 635.
5. Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z. Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertil Steril 2010; 93: 1208-1214. [DOI:10.1016/j.fertnstert.2008.11.031]
6. Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr 2009; 139: 1157-1161. [DOI:10.3945/jn.108.103168]
7. Abedi P, Mohaghegh Z, Afshary P, Latifi M. The relationship of serum vitamin D with pre‐eclampsia in the Iranian women. Matern Child Nutr 2014; 10: 206-212. [DOI:10.1111/mcn.12058]
8. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 1997; 16: 391-396. [DOI:10.1038/ng0897-391]
9. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads 1. Endocrinology 2000; 141: 1317-1324. [DOI:10.1210/endo.141.4.7403]
10. Lerchbaum E, Obermayer-Pietsch B. Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012; 166: 765-778. [DOI:10.1530/EJE-11-0984]
11. Estes SJ, Ye B, Qiu W, Cramer D, Hornstein MD, Missmer SA. A proteomic analysis of IVF follicular fluid in women≤ 32 years old. Fertil Steril 2009; 92: 1569-1578. [DOI:10.1016/j.fertnstert.2008.08.120]
12. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94: 1314-1319. [DOI:10.1016/j.fertnstert.2009.05.019]
13. Rudick B, Ingles S, Stanczyk F, Chung K, Paulson R, Bendikson K. Characterizing the role of vitamin D levels on IVF outcomes: stimulation, embryo, or endometrium? Fertil Steril 2010; 94: S72. [DOI:10.1016/j.fertnstert.2010.07.280]
14. Aleyasin A, Hosseini MA, Mahdavi A, Safdarian L, Fallahi P, Mohajeri MR, et al. Predictive value of the level of vitamin D in follicular fluid on the outcome of assisted reproductive technology. Eur J Obstet Gynecol Reprod Biol 2011; 159: 132-137. [DOI:10.1016/j.ejogrb.2011.07.006]
15. Anifandis GM, Dafopoulos K, Messini CI, Chalvatzas N, Liakos N, Pournaras S, et al. Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome. Reprod Biol Endocrinol 2010; 8: 91. [DOI:10.1186/1477-7827-8-91]
16. Joo BS, Park SH, An BM, Kim KS, Moon SE, Moon HS. Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner. Fertil Steril 2010; 93: 442-446. [DOI:10.1016/j.fertnstert.2009.02.066]
17. Imudia AN, Goldman RH, Awonuga AO, Wright DL, Styer AK, Toth TL. The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles. J Assist Reprod Genet 2014; 31: 65-71. [DOI:10.1007/s10815-013-0117-8]
18. Pe-a JE, Chang PL, Chan L-K, Zeitoun K, Thornton MH, Sauer MV. Supraphysiological estradiol levels do not affect oocyte and embryo quality in oocyte donation cycles. Hum Reprod 2002; 17: 83-87. [DOI:10.1093/humrep/17.1.83]
19. Ozdegirmenci O, Dilbaz S, Cinar O, Aydin S, Beydilli G, Cakir L, et al. Can serum oestradiol be a predictor of quality of oocytes and embryos, maturation of oocytes and pregnancy rate in ICSI cycles? Gynecol Endocrinol 2011; 27: 279-285. [DOI:10.3109/09513590.2010.491168]
20. Kondapalli L, Molinaro T, Sammel M, Dokras A. A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles. Hum Reprod 2012; 27: 2690-2697. [DOI:10.1093/humrep/des216]
21. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res 2010; 42: 754. [DOI:10.1055/s-0030-1262837]
22. Xia P. Intracytoplasmic sperm injection: correlation of oocyte grade based on polar body, perivitelline space and cytoplasmic inclusions with fertilization rate and embryo quality. Hum Reprod 1997; 12: 1750-1755. [DOI:10.1093/humrep/12.8.1750]
23. Aflatoonian A, Mashayekhy M, Mohamadian F, Moghaddam FM. The correlation between follicular fluid anti-mullerian hormone levels and fertilization and embryo quality in ART cycles. Iran J Reprod Med 2010; 8: 157-160.
24. Dehghani Firouzabadi R, Mohammadian F, Mashayekhy M, Davar R, Eftekhar M. The correlation between follicular fluid pregnancy-associated plasma protein A levels, fertilization, and embryo quality in GnRH agonist and GnRH antagonist protocols in ART cycles. Iran J Reprod Med 2012; 10: 477-482.
25. Mehdizadeh A, Rahimipour A, Farzadi L, Darabi M, Shahnazi V, Shaaker M, et al. Correlation between the level of cholesteryl ester transfer protein in follicular fluid with fertilization rates in IVF/ICSI cycles. Iran J Reprod Med 2011; 9: 193-198.
26. Liu N, Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys 2012; 523: 37-47. [DOI:10.1016/j.abb.2011.11.018]
27. Pasco JA, Wark JD, Carlin JB, Ponsonby A-L, Vuillermin PJ, Morley R. Maternal vitamin D in pregnancy may influence not only offspring bone mass but other aspects of musculoskeletal health and adiposity. Med Hypothes 2008; 71: 266-269. [DOI:10.1016/j.mehy.2008.01.033]
28. Rudick B, Ingles S, Stanczyk F, Chung K, Paulson R, Bendikson K. The role of vitamin D levels on IVF outcomes in donor-recipient cycles. Fertil Steril 2011; 95: S8. [DOI:10.1016/j.fertnstert.2011.01.053]
29. Vigano P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol 2006; 36: 415-424. [DOI:10.1677/jme.1.01946]
30. Aflatoonian A, Modarresi S, Sekhavat L, MohammadTaheri S. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Comp Ther Clin Pract 2012; 18: 85-88. [DOI:10.1016/j.ctcp.2012.01.005]
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