International Journal of
Reproductive Biomedicine
Sat, Sep 21, 2024
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Volume 13, Issue 7 (9-2015)
IJRM 2015, 13(7): 439-444 |
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Soleimani Rad S, Abbasalizadeh S, Ghorbani Haghjo A, Sadagheyani M, Montaseri A, Soleimani Rad J. Evaluation of the melatonin and oxidative stress markers level in serum of fertile and infertile women. IJRM 2015; 13 (7) :439-444
URL: http://ijrm.ir/article-1-661-en.html
URL: http://ijrm.ir/article-1-661-en.html
Sara Soleimani Rad1 
, Shamsi Abbasalizadeh2 , Amir Ghorbani Haghjo3 , Mehzad Sadagheyani1 , Azadeh Montaseri4 , Jafar Soleimani Rad * 5
, Shamsi Abbasalizadeh2 , Amir Ghorbani Haghjo3 , Mehzad Sadagheyani1 , Azadeh Montaseri4 , Jafar Soleimani Rad * 5
1- Department of Obstetrics and Gynecology, Alzahra Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2- Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz-Iran
3- Department of Medical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4- Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5- Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ,soleimanirj@yahoo.com
2- Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz-Iran
3- Department of Medical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4- Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5- Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract: (2427 Views)
Background: Infertility is defined as the inability to achieve the pregnancy within a year of unprotected intercourse. Infertility is a complex issue and different factors such as stress oxidative can be involved in this problem. So, any attempt to neutralize oxidative stress would be helpful in the treatment of infertility. Melatonin is a known scavenger of free radicals.
Objective: The aim of our study was to evaluate the level of melatonin and its correlation with oxidative biomarkers in fertile and infertile women.
Materials and Methods: The participants including fertile and infertile women were divided into two groups of 30 people. Blood sampling was performed and sera were collected. The level of Malondialdehyde (MDA), total antioxidant capacity (TAC) and melatonin were detected. Data were analyzed using T-test and their correlation was assessed using Spearman test.
Results: Serum melatonin from fertile women was higher than infertile women but the difference was not significant (p= 0.46). MDA level in fertile women was significantly lower than infertile women (p<0.001) and the level of TAC in fertile women was significantly higher than infertile women (p<0.001). Spearman test revealed a significant and direct correlation between melatonin and TAC in fertile and infertile women and a significant but reverse correlation between melatonin and MDA in infertile and fertile women.
Conclusion: Differences in the level of oxidative stress biomarkers in fertile and infertile individuals have been reported. This study revealed a significant correlation between melatonin and oxidative stress biomarkers, concluding that melatonin level could be involved in infertility.
Objective: The aim of our study was to evaluate the level of melatonin and its correlation with oxidative biomarkers in fertile and infertile women.
Materials and Methods: The participants including fertile and infertile women were divided into two groups of 30 people. Blood sampling was performed and sera were collected. The level of Malondialdehyde (MDA), total antioxidant capacity (TAC) and melatonin were detected. Data were analyzed using T-test and their correlation was assessed using Spearman test.
Results: Serum melatonin from fertile women was higher than infertile women but the difference was not significant (p= 0.46). MDA level in fertile women was significantly lower than infertile women (p<0.001) and the level of TAC in fertile women was significantly higher than infertile women (p<0.001). Spearman test revealed a significant and direct correlation between melatonin and TAC in fertile and infertile women and a significant but reverse correlation between melatonin and MDA in infertile and fertile women.
Conclusion: Differences in the level of oxidative stress biomarkers in fertile and infertile individuals have been reported. This study revealed a significant correlation between melatonin and oxidative stress biomarkers, concluding that melatonin level could be involved in infertility.
Type of Study: Original Article |
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