Volume 13, Issue 7 (9-2015)                   IJRM 2015, 13(7): 421-424 | Back to browse issues page

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Ghaneei A, Yassini S, Ghanei M E, Shojaoddiny Ardekani A. Increased serum oxidized low-density lipoprotein levels in pregnancies complicated by gestational diabetes mellitus. IJRM 2015; 13 (7) :421-424
URL: http://ijrm.ir/article-1-666-en.html
Increased serum oxidized low-density lipoprotein levels in pregnancies complicated by gestational diabetes mellitus
Azam Ghaneei1 , Sara Yassini2 , Mohammad Ebrahim Ghanei3 , Ahmad Shojaoddiny Ardekani * 4
1- Department of Endocrinology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Radiologist, Isfahan University of Medical Sciences, Isfahan, Iran
4- Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Dr.Shojaaddiny@gmail.com
Abstract:   (2193 Views)
Background: Elevated serum levels of oxidized Low-density Lipoprotein (oxLDL) have been found in type 2 and in poorly controlled diabetic patients. Gestational diabetes mellitus (GDM) has common features with type 2 diabetes.
Objective: The aim of our study was to evaluate the serum levels of oxLDL in women with GDM compared to normal pregnant women.
Materials and Methods: In this cross-sectional study, ninety-two subjects were randomly allocated to either GDM (n=46) or control (n=46) groups matched for age, body mass index and parity from March 2013 to March 2014. GDM was diagnosed according to the American Diabetes Association criteria at 24-26 weeks of gestation. OxLDL was measured using enzyme-linked immunosorbent assay. T-test and Pearson correlation coefficients were applied for analyzing the data by using SPSS version 17.
Results: Compared to the controls, significantly higher oxLDL levels were found in the GDM group (17.16 ± 3.71 U/L vs. 8.77 ± 1.84 U/L, respectively, p < 0.001). No significant correlations were found between oxLDL and age and BMI of the patients in the groups.
Conclusion: Our study found significant increase of oxLDL in GDM emphasizing the role of short-term hyperglycemia in the formation of oxLDL during GDM. The importance of aptly diagnosis of GDM in maternal health may also be concluded.
Keywords: Oxidized low-density lipoprotein, Gestational diabetes, Pregnancy, Body mass
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Type of Study: Original Article |
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