Volume 13, Issue 9 (10-2015)                   IJRM 2015, 13(9): 533-540 | Back to browse issues page

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Kazemi A, Ramezanzadeh F, Nasr-Esfahani M H. The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes. IJRM 2015; 13 (9) :533-540
URL: http://ijrm.ssu.ac.ir/article-1-682-en.html
1- Reproductive Health Department, Nursing and Midwifery Care Research Centere, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran , kazemi@nm.mui.ac.ir
2- Vali-e-Asr Reproductive Health Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3- Reproductive Biomedicine Center, Royan Institute for Animal Biotechnology, ACECR, Department of Reproduction and Development, Isfahan, Iran
Abstract:   (2482 Views)
Background: Oxidative stress (OS) in the follicular environment may affect on oocyte competence and antioxidant vitamins may modify its effects.
Objective: This study was conducted to examine the effect of dietary intake of vitamin A, C and E on OS in follicular environment and assisted reproduction technology (ART) outcomes.
Materials and Methods: In this obsevationalprospective study, the intake levels of vitamin A, C, and E were matured by validated food frequency questionnaire and Malondialdehyde and the total antioxidant capacity (TAC) levels of follicular fluid (FF) in 219 women undergoing ART were assessed. The number of retrieved oocytes, percentages of metaphase II MII) stage oocytes, fertilization rate, and embryo quality were also determined.
Results: No significant association was found between vitamins intake levels and OS biomarkers, but the mean of TAC level in FF among women who received vitamin C greater than 75 mg/d was higher than women with lower intakes (p<0.05). The ART parameters were not related to the vitamin E intake level, but the normal cleaved embryo rate was positively related to vitamin A (p<0.05) and vitamin C (p=0.02) intake levels. Also, the percentage of MII oocytes (p=0.02) and the fertilization rate (p<0.05) were related to the vitamin C intake level. The relation between the TAC level in FF and ART outcomes were not significant.
Conclusion: Current results indicated that high dietary intake of vitamin C would be followed by increasing the TAC level in FF and improving the oocyte competence, but this effect of vitamin C is not dependent of increasing of antioxidant defense in follicular environment.
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Type of Study: Original Article |

References
1. Combelles CM, Carabatsos MJ, Kumar TR, Matzuk MM, Albertini DF. Hormonal control of somatic cell oocyte interactions during ovarian follicle development. Mol Reprod Dev 2004; 69:347-355. [DOI:10.1002/mrd.20128]
2. Sirard MA, Richard F, Blondin P, Robert C. Contribution of the oocyte to embryo quality. Theriogenology 2006; 65:126–136. [DOI:10.1016/j.theriogenology.2005.09.020]
3. Hendriksen PJ, Vos PL, Steenweg WN, Bevers MM, Dieleman SJ. Bovine follicular development and its effect on the in vitro competence of oocytes. Theriogenology 2000; 53:11–20. [DOI:10.1016/S0093-691X(99)00236-8]
4. Bertout J, Mahutte NG, Preston SL, Behrman HR. Reactive oxygen species and ovarian function. In: Leung P; Adashi EY. The Ovary. San Diego: Elsevier Academic Press; 2004; 353-368. [DOI:10.1016/B978-012444562-8/50021-5]
5. Guerin P, El Mouatassim S, Menezo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update 2001; 7:175–189. [DOI:10.1093/humupd/7.2.175]
6. Matos L, Stevenson D, Gomes F, Silva-Carvalho JL, Almeida H. Superoxide dismutase expression in human cumulus oophorus cells. Mol Hum Reprod 2009;15:411-419. [DOI:10.1093/molehr/gap034]
7. Hanukoglu I. Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells. Drug Metab Rev 2006; 38:171–196. [DOI:10.1080/03602530600570040]
8. Zhang X, Li XH, Ma X, Wang ZH, Lu S, Guo YL. Redox-induced apoptosis of human oocytes in resting follicles in vitro. J Soc Gynecol Investig 2006; 13:451–458. [DOI:10.1016/j.jsgi.2006.05.005]
9. Valdez KE, Cuneo SP, Turzillo AM. Regulation of apoptosis in the atresia of dominant bovine follicles of the first follicular wave following ovulation. Reproduction 2005; 130: 71–81. [DOI:10.1530/rep.1.00430]
10. Benyamini Y, Gozlan M, Kokia E. Women's and men's perceptions of infertility and their associations with psychological adjustment: a dyadic approach. Br J Health Psychol 2009; 14:1-16. [DOI:10.1348/135910708X279288]
11. Das S, Chattopadhyay R, Ghosh S, Goswami SK, Chakravarty BN, Chaudhury K. Reactive oxygen species level in follicular fluid embryo quality marker in IVF? Hum Reprod 2006; 21:2403–2407. [DOI:10.1093/humrep/del156]
12. Oyawoye O, Abdel Gadir A, Garner A, Constantinovici N, Perrett C, Hardiman P. Antioxidants and reactive oxygen species in follicular fluid of women undergoing IVF: relationship to outcome. Hum Reprod 2003; 18: 2270-2274. [DOI:10.1093/humrep/deg450]
13. Song YL, Quan S, Tian JW, Li H, Chen SM, Xing FQ. Relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29:160-163.
14. Sefi M, Ben Amara I, Troudi A, Soudani N, Hakim A, Zeghal KM, et al. Effect of selenium on methimazole-induced liver damage and oxidative stress in adult rats and their offspring. Toxicol Ind Health 2012; 30:653-669. [DOI:10.1177/0748233712462445]
15. Amin KA, Kamel HH, Abd Eltawab MA. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids Health Dis 2011; 10:6. [DOI:10.1186/1476-511X-10-6]
16. Sugino N. Reactive oxygen species in ovarian physiology. Reprod Med Biol 2005; 4: 31-44.
17. Tola EN, Mungan MT, Uğuz AC, Naziroğlu M. Intracellular Ca2+ and antioxidant values induced positive effect on fertilisation ratio and oocyte quality of granulosa cells in patients undergoing in vitro fertilisation. Reprod Fertil Dev 2013; 25:746-752. [DOI:10.1071/RD12144]
18. Ozkaya MO, Nazıroglu M. Multivitamin and mineral supplementation modulates oxidative stress and antioxidant vitamin levels in serum and follicular fluid of women undergoing in vitro fertilization. Fertil Steril 2010; 94: 2465-2466. [DOI:10.1016/j.fertnstert.2010.01.066]
19. Arrigoni O, De Tullio MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta 2002;1569:1-9. [DOI:10.1016/S0304-4165(01)00235-5]
20. Nadri B, Zeinoaldini S, Kohram H. Ascorbic acid effects on in vitro maturation of mouse oocyte with or without cumulus cell. African Journal of Biotechnology 2009; 8:5627-5631.
21. Thomas FH, Leask R, Srsen V, Riley SC, Spears N, Telfer EE. Effect of ascorbic acid on health and morphology of bovine preantral follicles during long-term culture. Reproduction 2001; 122: 487–495. [DOI:10.1530/rep.0.1220487]
22. Dalvit G, Llanes SP, Descalzo A, Insani M, Beconi M, Cetica P. Effect of alpha-tocopherol and ascorbic acid on bovine oocyte in-vitro maturation. Reprod Domest Anim 2005; 40:93–97. [DOI:10.1111/j.1439-0531.2004.00522.x]
23. Duque P, Diez C, Royo L, Lorenzo PL, Carneiro G, Hidalgo CO, et al. Enhancement of developmental capacity of meiotically inhibited bovine oocytes by retinoic acid. Hum Reprod 2002; 17: 2706–2714. [DOI:10.1093/humrep/17.10.2706]
24. Ikeda S, Kitagawa M, Imai H, Yamada M. The roles of vitamin A for cytoplasmic maturation of Bovine oocytes. J Reprod Dev 2005; 51: 23-35. [DOI:10.1262/jrd.51.23]
25. Laboratory manual of the WHO for the examination of human semen and sperm-cervical mucus interaction). Ann Ist Super Sanita 2001;37: 1-123.
26. Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr 2010; 13: 654-662. [DOI:10.1017/S1368980009991698]
27. Veeck LL. Oocyte assessment and biological performance. Ann N Y Acad Sci 1988; 541: 259-274. [DOI:10.1111/j.1749-6632.1988.tb22263.x]
28. Oral O, Kutlu T, Aksoy E, Fccolu C, Uslu H, Turul S. The effects of oxidative stress on outcomes of assisted reproductive techniques. J Assist Reprod Genet 2006; 23:81-85. [DOI:10.1007/s10815-005-9010-4]
29. Attaran M, Pasqualotto E, Falcone T, Goldberg JM, Miller KF, Agarwal A, et al. The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. Int J Fertil Women's Med 2000;45:314-320.
30. Choi WJ, Banerjee J, Falcone T, Bena J, Agarwal A, Sharma RK. Oxidative stress and tumor necrosis factor-alpha-induced alterations in metaphase II mouse oocyte spindle structure. Fertil Steril 2007; 88:1220– 1231. [DOI:10.1016/j.fertnstert.2007.02.067]
31. Tatemoto H, Ootaki K, Shigeta K, Muto N. Enhancement of developmental competence after in vitro fertilization of porcine oocytes by treatment with ascorbic acid 2-O-a-glucoside during in vitro maturation. Biol Reprod 2001; 65:1800–1806. [DOI:10.1095/biolreprod65.6.1800]
32. Eppig JJ, Hosoe M, OBrien MJ, Pendola FM, Requena A, Watanabe S. Conditions that affect acquisition of developmental competence by mouse oocytes in vitro: FSH, insulin, glucose and ascorbic acid. Mol Cell Endocrinol 2000; 163:109–116. [DOI:10.1016/S0303-7207(99)00247-6]
33. Botero D, Ebbeling CB, Blumberg JB, Ribaya-Mercado JD, Creager MA, Swain JF, et al. Acute effects of dietary glycemic index on antioxidant capacity in a nutrient-controlled feeding study. Obesity 2009;17:1664-1670. [DOI:10.1038/oby.2009.203]
34. Combelles CMH, Gupta S, Agarwal A. Could oxidative stress influence the in-vitro maturation of oocytes? Reprod Biomed Online 2009; 18: 864–880. [DOI:10.1016/S1472-6483(10)60038-7]
35. Ong DE, Page DL. Quantitation of cellular retinol-binding protein in human organs. Am J Clin Nutr 1986; 44: 425–430. [DOI:10.1093/ajcn/44.3.425]
36. Schweigert FJ, Steinhagen B, Raila J, Siemann A, Peet D, Buscher U. Concentrations of carotenoids, retinol and alpha-tocopherol in plasma and follicular fluid of women undergoing IVF. Hum Reprod 2003; 18:1259–1264. [DOI:10.1093/humrep/deg249]

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