Volume 14, Issue 10 (10-2016)                   IJRM 2016, 14(10): 625-628 | Back to browse issues page

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Nazari L, Salehpour S, Hoseini S, Zadehmodarres S. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. IJRM 2016; 14 (10) :625-628
URL: http://ijrm.ir/article-1-700-en.html
Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study
Leila Nazari * 1, Saghar Salehpour2 , Sedighe Hoseini2 , Shahrzad Zadehmodarres2
1- Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran , nazari@sbmu.ac.ir
2- Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (3347 Views)
Background: Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one.
Objective: This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients.
Materials and Methods: Twenty women with a history of RIF who were candidates for frozen-thawed embryo transfer were recruited in this study. Intrauterine infusion of 0.5 ml of platelet-rich plasma that contained platelet 4-5 times more than peripheral blood sample was performed 48 hrs before blastocyst transfer.
Results: Eighteen participants were pregnant with one early miscarriage and one molar pregnancy. Sixteen clinical pregnancies were recorded and their pregnancies are ongoing.
Conclusion: According to this study, it seems that platelet-rich plasma is effective in improvement of pregnancy outcome in RIF patients
Keywords: Platelet-rich plasma, Implantation, Fertilization in Vitro, Pregnancy rate, Repeated implantation failure.
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Type of Study: Original Article |
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