Volume 14, Issue 12 (12-2016)                   IJRM 2016, 14(12): 777-782 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Temitope Okunola O, Kayode Ajenifuja O, Olabisi Loto M, Salawu A, Stephen Omitinde O, Akande J et al . Age-specific nomograms for follicle stimulating hormone and anti-Mullerian hormone: A pilot study in Ile-Ife, Nigeria. IJRM 2016; 14 (12) :777-782
URL: http://ijrm.ir/article-1-711-en.html
1- Department of Obstetrics and Gynecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria , bezaleelokunola@yahoo.com
2- Department of Obstetrics and Gynecology, Obafemi Awolowo University, Ile-Ife, Nigeria
3- Department of Chemical Pathology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Nigeria
4- Department of Obstetrics and Gynecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
Abstract:   (2705 Views)
Background: Assessment of ovarian reserve is one of the steps in the management of infertile couples. Follicle Stimulating hormone (FSH) and anti-Müllerian hormone (AMH) are commonly used ovarian reserve markers in Africa. However, there is paucity of age-specific reference values for FSH and AMH among the African population.
Objective: This study aimed at conducting a pilot study for generation of age-specific nomograms for FSH and AMH among fertile women in Ile-Ife, Nigeria.
Materials and Methods: A pilot cross-sectional study that involved 65 fertile women within the age range of 18-45 yr were prospectively and consecutively recruited from November 2014 to January 2015. Peripheral blood samples were taken for basal serum FSH and random serum AMH. The samples were processed using enzyme linked immunosorbent (ELISA) assays.
Results: Age-specific FSH nomogram showed a gradual increase which became steeper at age 35 yr with an average yearly increase of 0.2 IU/L in basal serum FSH, while age-specific AMH nomogram showed a peak at 25 yr and then; an average yearly decrease of 0.11 ng/ml in random serum AMH from 25 yr.
Conclusion: The age-specific nomograms generated by this pilot study suggest that AMH may be an earlier marker of reduced ovarian reserve; which if validated by future multicenter population based studies may facilitate counseling of women on their reproductive potentials.
Full-Text [PDF 163 kb]   (1000 Downloads) |   |   Full-Text (HTML)  (455 Views)  
Type of Study: Original Article |

References
1. Roudebush WE, Kivens WJ, Mattke JM. Biomarkers of ovarian reserve. Biomark Insights 2008; 3: 259-268. [DOI:10.4137/BMI.S537]
2. la Marca A, Giulini S, Tirena A. Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology. Hum Reprod 2007; 22: 766-771. [DOI:10.1093/humrep/del421]
3. Braid DT, Collins J, Egozcue J, Evers LH, Gianaroli L, Leridon H, et al. Fertility and Ageing. Hum Reprod Update 2005; 11: 261-276. [DOI:10.1093/humupd/dmi006]
4. Coccia ME, Rizzello F. Ovarian reserve. Ann N Y Acad Sci 2008; 1127: 27-30. [DOI:10.1196/annals.1434.011]
5. Padma RJ. Ovarian reserve tests. J Hum Reprod Sci 2011; 4: 108-113. [DOI:10.4103/0974-1208.92283]
6. Sills ES, Alper MM, Walsh AP. Ovarian reserve screening in infertility: practical applications and theoretical directions for research. Eur J Obstet Gynaecol Reprod Biol 2009; 146: 30-36. [DOI:10.1016/j.ejogrb.2009.05.008]
7. Sharara FI, McClamrock HD. The effect of aging on ovarian volume measurements in infertile women. Obstet Gynaecol 1999; 94: 57-60.
8. Perloe M, Levy DP, Sills ES. Strategies for ascertaining ovarian reserve among women suspected of subfertility. Int J Fertil Womens Med 2000; 45: 215-224.
9. Sharara FI, ScottJr RT, Scheifer DB. The detection of diminished ovarian reserve in infertile women. Am J Obstet Gynaecol 1998; 179: 804-812. [DOI:10.1016/S0002-9378(98)70087-0]
10. Van Rooij IA, Broekmans FJ, te Velde ER. Fauser BC, BancsiLF, de Jong, et al. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod 2002; 17: 3065-3071. [DOI:10.1093/humrep/17.12.3065]
11. Broer SL, Dolleman M, Opmer BC, Fauser BC, Mol BW, Broekmans FJ. AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: A meta-analysis. Hum Reprod Update 2011; 17: 46-54. [DOI:10.1093/humupd/dmq034]
12. Grisendi V, Spada E, Argento C, Plebani M, Milani S, Seracchioli R, et al. Age-specific reference values for serum FSH and estradiol levels throughout the reproductive period. Gynecol Endocrinol 2014; 30: 451-455. [DOI:10.3109/09513590.2014.893572]
13. La Marca A, Spada E, Grisendi V, Argento C, Papaleo E, Milani S, et al. Normal serum anti-Müllerian hormone levels in the general female population and the relationship with reproductive history. Eur J Obstet Gynaecol Reprod Biol 2012; 163: 180-184. [DOI:10.1016/j.ejogrb.2012.04.013]
14. Wallace HW, Kelsey HW. Ovarian reserve and reproductive age may be determined from measurement of ovarian volume from transvaginal sonography. Hum Reprod 2004; 19: 1692-1697. [DOI:10.1093/humrep/deh285]
15. Lie Fong S, Visser JA, Welt CK, de Rijke YB, Eijkemans MJC, Broekmans FJ, et al. Serum Anti-Müllerian Hormone Levels in Healthy Females: A Normogram Ranging from Infancy to Adulthood. J Clin Endocrinol Metab 2012; 97: 4650-4655. [DOI:10.1210/jc.2012-1440]
16. Kelsey TW, Wright P, Nelson SM, Anderson RA, Wallace WH. A validated model of serum anti-Müllerian hormone from conception to menopause. PLos One 2011; 6: e22024. [DOI:10.1371/journal.pone.0022024]
17. La Marca A, Spada E, Grisendi V, Argento C, Papaelo E, Milani S, et al. Normal serum anti-Mullerian hormone levels in the general female population and the relationship with reproductive history. Eur J Obstet Gynaecol Reprod Biol 2012; 163: 180-184. [DOI:10.1016/j.ejogrb.2012.04.013]
18. de Bruin JP, teVelde ER. Female reproductive aging: concepts and consequences. In: Tulandi T, Gosden R.G, editors. Preservation of fertility: London: Taylor and Francis; 2004 p 3.
19. Wood JW. Fecundity and natural fertility in humans. Oxf Ref Reprod Biol 1989; 11: 61-109.

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb