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Volume 5, Issue 3 (7-2007)
IJRM 2007, 5(3): 57-0 |
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Ayaty S, Vahid Roudsari F, Tavassoly F. CA-125 in normal pregnancy and threatened abortion. IJRM 2007; 5 (3) :57-0
URL: http://ijrm.ir/article-1-73-en.html
URL: http://ijrm.ir/article-1-73-en.html
1- Ghaem Hospital-Mashhad University of Medical Sciences, Mashhad, Iran , ff_vahid @ yahoo.com
2- Ghaem Hospital-Mashhad University of Medical Sciences, Mashhad, Iran
3- Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2- Ghaem Hospital-Mashhad University of Medical Sciences, Mashhad, Iran
3- Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract: (1849 Views)
Background: CA-125 is a glycoprotein and its origin is uncertain during pregnancy. It arises during the first trimester and return to a non-pregnancy range in late pregnancy.
Objective: The aim of this study was to compare CA-125 level in threatened abortion and normal pregnancy less than 20 weeks of pregnancy.
Materials and Methods: This was a prospective case study carried out on 50 healthy pregnant (group 1) and 50 threatened abortion women (group 2). We compared the levels of CA-125 in these groups and followed them to be informed of the outcome of pregnancy.
Results: Fifty percent of women were in 20-24 years old group, primigravida and in the first trimester of pregnancy. The mean level of CA-125 in group 1 was 26.2 ± 3.25 IU/ml and in group 2 was 37.44 ± 2.72 IU/ml. The mean level of CA-125 in finally aborted patients was 58.17±7.25 IU/ml and in normal pregnant women, who continue to term, was 26.61±1.76 IU/ml. The CA-125 level in threatened women,whose pregnancy continued and did not abort, was 30.89 IU/ml. There was statistically significant difference between mean serum CA-125 levels of two groups (p < 0.05), while there was no statistically significant difference between these levels in the patients of both groups who continued pregnancies (p > 0.1). In group 2, there was a statistically significant difference in the level of CA-125 between those who developed abortion and those whose pregnancy continued but not aborted (p < 0.05).
Conclusion: Measurement of serum CA-125 may be an inexpensive, easily available, sensitive and specific predictor of outcome in threatened abortion, which results the loss of pregnancy.
Objective: The aim of this study was to compare CA-125 level in threatened abortion and normal pregnancy less than 20 weeks of pregnancy.
Materials and Methods: This was a prospective case study carried out on 50 healthy pregnant (group 1) and 50 threatened abortion women (group 2). We compared the levels of CA-125 in these groups and followed them to be informed of the outcome of pregnancy.
Results: Fifty percent of women were in 20-24 years old group, primigravida and in the first trimester of pregnancy. The mean level of CA-125 in group 1 was 26.2 ± 3.25 IU/ml and in group 2 was 37.44 ± 2.72 IU/ml. The mean level of CA-125 in finally aborted patients was 58.17±7.25 IU/ml and in normal pregnant women, who continue to term, was 26.61±1.76 IU/ml. The CA-125 level in threatened women,whose pregnancy continued and did not abort, was 30.89 IU/ml. There was statistically significant difference between mean serum CA-125 levels of two groups (p < 0.05), while there was no statistically significant difference between these levels in the patients of both groups who continued pregnancies (p > 0.1). In group 2, there was a statistically significant difference in the level of CA-125 between those who developed abortion and those whose pregnancy continued but not aborted (p < 0.05).
Conclusion: Measurement of serum CA-125 may be an inexpensive, easily available, sensitive and specific predictor of outcome in threatened abortion, which results the loss of pregnancy.
Type of Study: Original Article |
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