Volume 14, Issue 4 (4-2016)                   IJRM 2016, 14(4): 241-246 | Back to browse issues page

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Hassani M, Saliminejad K, Heidarizadeh M, Kamali K, Memariani T, Khorram Khorshid H R. Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population. IJRM 2016; 14 (4) :241-246
URL: http://ijrm.ir/article-1-744-en.html
1- Department of Biology, Faculty of Science, University of Kurdistan, Sanandaj, Iran
2- Reproductive Biotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran
3- Central Research Lab, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Genetic Research Center, University of Social Welfare and Rehabilitation Science, Tehran, Iran , hrkk1@uswr.ac.ir
Abstract:   (2339 Views)
Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.
Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population.
Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.
Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).
Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.
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Type of Study: Original Article |

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