Volume 14, Issue 6 (6-2016)                   IJRM 2016, 14(6): 421-426 | Back to browse issues page

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Mesdaghi-nia E, Behrashi M, Saeidi A, Abedzadeh Kalahroodi M. Association between PAPP-A and placental thickness. IJRM 2016; 14 (6) :421-426
URL: http://ijrm.ir/article-1-755-en.html
Association between PAPP-A and placental thickness
Elaheh Mesdaghi-nia1 , Mitra Behrashi1 , Arezoo Saeidi * 2, Masoomeh Abedzadeh Kalahroodi3
1- Kashan University of Medical Sciences, Kashan, Iran
2- Kashan University of Medical Sciences, Kashan, Iran , Saeidi.arezoo62@gmail.com
3- Truma Medical Center, Kashan University of Medical Sciences, Kashan, Iran
Abstract:   (2541 Views)
Background: Measuring of maternal serum pregnancy-associated plasma protein-A (PAPP-A) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta.
Objective: The aim was to Determination of association between placental thickness in second trimester with low level of PAPP-A in first trimester.
Materials and Methods: In this cohort study, serum PAPP-A of 187 pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A ≤0.8 MOM were in exposed and others who had PAPP-A >0.8 defined as unexposed group. The criteria of placental thickness in ultrasound study was thickness of 4 cm or more than 50% of placental length.
Results: Of 187 patients, 87 patients had PAPP-A >0.8 and 93 patients had PAPP-A ≤0.8. Women with low levels of PAPP-A in the first trimester, had an increased incidence placental thickness of 34.4%, whereas another group had about 15% (p=0.002). Also, PAPP-A levels had acceptable sensitivity and specificity for placental thickness detection (71.1% and 54.8%, respectively.
Conclusion: Our study showed that serum level of PAPP-A generally was low (≤0.8) in women with a thick placenta (>4 cm or >50% of placental length). The first trimester of pregnancy measurement of PAPP-A will be more predictable for healthy placenta.
Keywords: Pregnancy-associated plasma protein-A (PAPP-A), Pregnancy, Placenta
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Type of Study: Original Article |
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