Volume 14, Issue 8 (8-2016)                   IJRM 2016, 14(8): 507-510 | Back to browse issues page

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Eftekhar M, Miraj S, Mortazavifar Z. The effect of luteal phase gonadotropin-releasing hormone antagonist administration on IVF outcomes in women at risk of OHSS. IJRM 2016; 14 (8) :507-510
URL: http://ijrm.ir/article-1-777-en.html
The effect of luteal phase gonadotropin-releasing hormone antagonist administration on IVF outcomes in women at risk of OHSS
Maryam Eftekhar1 , Sepideh Miraj * 2, Zahrasadat Mortazavifar1
1- Research and Clinical Center for Infertility, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Research and Clinical Center for Infertility, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , dr.s.miraj@gmail.com
Abstract:   (3436 Views)
Background: Gonadotropin-releasing hormone (GnRH) plays essential roles in embryo implantation, invasion of trophoblastic tissue, and steroid synthesis in the placenta.
Objective: The aim of this study was to evaluate the effect of GnRH antagonist administration on pregnancy outcomes in early implantation period.
Materials and Methods: In this retrospective study, 94 infertile women undergoing GnRH antagonist protocol who were at risk of ovarian hyperstimulation syndrome (OHSS) were included. Sixty-seven patients (group I) received Cetrorelix 0.25 mg/daily in the luteal phase for 3 days while in 27 participants (group II), it was not administered. Pregnancy outcomes were assessed based on chemical and clinical pregnancy rates.
Results: The pregnancy outcomes were not significantly different between two groups (p=0.224).
Conclusion: The present study proposed that luteal phase GnRH antagonist administration does not influence the chance of successful pregnancy outcomes.
Keywords: Gonadotropin-releasing hormone antagonist, Pregnancy outcome, In vitro fertilization.
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Type of Study: Original Article |
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