Volume 14, Issue 9 (9-2016)                   IJRM 2016, 14(9): 583-588 | Back to browse issues page

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Salehpour S, Zamaniyan M, Saharkhiz N, Zadeh modares S, Hosieni S, Seif S, et al . Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT. IJRM 2016; 14 (9) :583-588
URL: http://ijrm.ir/article-1-782-en.html
Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT
Saghar Salehpour1 , Marzieh Zamaniyan * 2, Nasrin Saharkhiz1 , Shahrzad Zadeh modares1 , Sedighe Hosieni1 , Samira Seif3 , Narges Malih4 , Parinaz Rezapoor4 , Mohammad-Reza Sohrabi4
1- Preventive Gynecology Research Center (PGRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Preventive Gynecology Research Center (PGRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran , marziehzamaniyan@gmail.com
3- Department of Veterinary Theriogenology and Obstetric, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Health and Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (3900 Views)
Background: Recurrent implantation failure is one of the most issues in IVF cycles.Some researchers found that beneficial effects of endometrial Scratching in womenwith recurrent implantation failure, while some authors demonstrated contrary results
Objective: The present study aimed to investigate the effect of intrauterine. Salineinfusion as a form of endometrial injury, during fresh in vitro fertilization-embryotransfer cycle, among patients with recurrent implantation failure.
Materials and Methods: In this clinical trial study 63 women undergoing assistedreproductive technology were divided into two groups either local endometrialinjury by intrauterine saline infusion during day 3-5 of the ongoing controlledovarian stimulation cycle, or IVF protocol performed without any other interventionin Taleghani Hospital, Tehran, Iran. The main outcome measure was clinicalpregnancy rates.
Results: Patients who received intra uterine saline infusion (n=20), had significantlylower clinical pregnancy numbers (1 vs. 9, p<0.05) and implantation rates (4.7% vs.41.6%, p<0.05), compared to controls (n=39). However, there was no significantdifference in miscarriage rates (9.4% vs. 8.7%, p>0.05) and multiple pregnancynumbers (1 vs. 3, p>0.05) between groups.
Conclusion: When intrauterine saline infusion as a form of endometrial injury isperformed during the ongoing IVF cycles it has negative effect on reproductiveoutcomes among patients with recurrent implantation failure.
Keywords: Artificial Insemination, Embryo implantation, Embryo Transfer, Fertilization in Vitro, Endometrium, Injuries, Pregnancy
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Type of Study: Original Article |
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