دوره 14، شماره 9 - ( 6-1395 )                   جلد 14 شماره 9 صفحات 566-557 | برگشت به فهرست نسخه ها


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Alyasin A, Mehdinejadiani S, Ghasemi M. GnRH agonist trigger versus hCG trigger in GnRH antagonist in IVF/ICSI cycles: A review article. IJRM 2016; 14 (9) :557-566
URL: http://ijrm.ir/article-1-786-fa.html
آل یاسین اشرف، مهدی نژادیانی شایسته، قاسمی مرضیه. تریگر با GnRH آگونیست در مقابل تریگر با hCG در سیکل های IVF/ICSI با پروتکل آنتاگونیست: مقاله مروری. International Journal of Reproductive BioMedicine. 1395; 14 (9) :557-566

URL: http://ijrm.ir/article-1-786-fa.html


1- گروه اندوکرینولوژی و نازایی، بیمارستان شریعتی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران
2- گروه آناتومی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران
3- گروه اندوکرینولوژی و نازایی، بیمارستان شریعتی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران ، drghasemim@yahoo.com
چکیده:   (3504 مشاهده)
به طور روتین 10000-5000 واحد hCG جهت بلوغ نهایی فولیکول و آزاد شدن تخمک به عنوان روش استاندارد استفاده می­شود. hCG با اثرات مشابه LH اما نیمه عمر طولانی­تر از آن اثرات لوتئوتروفیک داشته که سبب افزایش شیوع OHSS می­شود. در سال­های اخیر در بیماران در ریسک OHSS ،آگونیست GnRH جهت القاء بلوغ نهایی فولیکول و آزاد شدن تخمک در سیکل­های آنتاگونیست با هدف کاهش شیوع OHSS پیشنهاد شده است. برخی مطالعات نشان داده­اند که ترشح FSH و LH درونزاد بعد از تزریق آگونیست GnRH در سیکل­های IVF قادر است بلوغ نهایی فولیکول را پیش برده و سبب برداشت تخمک بارور و رشد طبیعی جنین و در نهایت حاملگی شود. اما بر اساس نتایج برخی دیگر از مطالعات وکارآزمایی­های بالینی مطرح شده که استفاده از تریگرآگونیست GnRH منجر به نقص فاز لوتئال شده که این وضعیت میزان لانه­گزینی و حاملگی بالینی را کاهش داده، همچنین میزان سقط در سیکل­های Fresh در مقایسه با IVF روتین افزایش یافته است. همچنین در سال­های اخیر مطالعاتی جهت اصلاح فاز لوتئال با هدف انتقال جنین Fresh انجام شده است .در این مقاله مروری، با مطالعه مطالعات متاآنالیز و مروری تریگر با GnRH آگونیست مزایا، معایب و همچنین رویکردهایی که سبب رفع مشکلات آن می­شوند را مورد بررسی قرار داده ایم. 
نوع مطالعه: Original Article |

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