Volume 5, Issue 5 (7-2007)                   IJRM 2007, 5(5): 137-150 | Back to browse issues page

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Youssry M, Ozmen B, Orief Y, Zohni K, Al-Hasani S. Human sperm DNA damage in the context of assisted reproductive techniques. IJRM 2007; 5 (5) :137-150
URL: http://ijrm.ir/article-1-93-en.html
Human sperm DNA damage in the context of assisted reproductive techniques
Mohamed Youssry1 , Batuhan Ozmen2 , Yasser Orief1 , Khaled Zohni3 , Safaa Al-Hasani * 4
1- Department of Obstetrics and Gynecology, University of Alexandria, Alexandria, Egypt
2- Department of Obstetrics and Gynecology, University of Ankara, Ankara, Turkey
3- Medical Sciences Division, Reproduction Unit, National Research Center, Egypt
4- Department of Obstetrics and Gynecology, University of Schleswig – Holstein, Luebeck, Germany , sf_alhasani@hotmail.com
Abstract:   (3357 Views)
Fertilization involves direct interaction of the sperm and oocyte, fusion of the cell membranes and :::::union::::: of male and female gamete genomes. The completion of this process and subsequent embryo development depend in part on the inherent integrity of the sperm DNA. Sperm genome quality has been emphasized for several years as playing a major role in early embryogenesis. There is clinical evidence showing that human sperm DNA damage may adversely affect reproductive outcomes and that spermatozoa of infertile men possess substantially more DNA damage than do spermatozoa of fertile men. Testing DNA integrity may help selecting spermatozoa with intact DNA or with the least amount of DNA damage for use in assisted reproductive techniques (ARTs). This review will focus on how sperm DNA is organized, what causes sperm DNA damage and what impact this damage may have on reproductive outcome.
Keywords: Fertilization, Sperm DNA damage, Assisted reproductive technique (ART).
Full-Text [PDF 180 kb]   (610 Downloads) |   |   Full-Text (HTML)  (407 Views)  
Type of Study: Original Article |
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