Volume 7, Issue 4 (7-2009)                   IJRM 2009, 7(4): 153-156 | Back to browse issues page

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Vahid Roudsari F, Ayati S, Ayatollahi H, Esmaeily H, Hasanzadeh M, Shahabian M et al . Comparison of maternal serum Tumor Necrosis Factor-alpha (TNF-α) in severe and mild preeclampsia versus normal pregnancy. IJRM 2009; 7 (4) :153-156
URL: http://ijrm.ir/article-1-158-en.html
Comparison of maternal serum Tumor Necrosis Factor-alpha (TNF-α) in severe and mild preeclampsia versus normal pregnancy
Fatemeh Vahid Roudsari1 , Sedigheh Ayati * 2, Hossein Ayatollahi3 , Habibollah Esmaeily4 , Maliheh Hasanzadeh1 , Masoud Shahabian1 , Leila Pour Ali1
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Obstetrics and Gynecology, Ghaem Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , ayatis@mums.ac.ir
3- Department of Hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Medicosocial, Ghaem Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (2425 Views)
Background: Preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. It is suggested that cytokines such as Tumor Necrosis Factor-alpha (TNF-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction.
Objective: The aim of this study was comparison of maternal serum TNF-α in severe and mild preeclampsia versus normal pregnancy.
Materials and Methods: This study was performed on 37 women with preeclampsia (17 mild and 20 severe preeclampsia) and 41 normotensive pregnant women with similar gestational age at third trimester of pregnancy. All the preeclamptic cases had blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg in a 24-h urine sample. Maternal serum TNF-α concentration was compared in all of them.
Results: The level of TNF-α concentration was not statistically different between the studied groups. No significant correlation was found between preeclampsia and control group as they were compared in the view of maternal serum TNF-α concentration.
Conclusion: These findings suggest that serum TNF-α is not significantly associated with preeclampsia.
Keywords: Tumor Necrosis Factor-alpha (TNF-α), Preeclampsia, Normal pregnancy
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Type of Study: Original Article |
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