International Journal of

Introduction
Cryptorchidism is the most common endocrine disorders in male pediatrics (1). Cryptorchidism literally means hidden or obscure testis and generally refers to an undescended or maldescended testis. Overall, 2% to 4% of term male newborns have cryptorchidism and it comes down to 1% until 6 months to 1 year approximately.  It   is   uncommon   to   descending testes after the first year of life spontaneously (2). Predisposing factors for cryptorchidism including low birth weight, small for gestational age, preterm delivery and maternal exposure to estrogen during the pregnancy (3). A recent study found that almost 23% of index patients with undescended testes (UDT) had a positive family history of cryptorchidism (4). In cryptorchidism, the most useful determination is whether the testes are palpable upon physical examination. Approximately 80% of undescended testes are palpable and 20% are nonpalpable. Nonpalpable testes may be intra-abdominal or absent. Palpable testes may be undescended, ectopic, or retractile (5). Therefore a gentle physical examination and screening by physician is needed. Treatment 
Table I. Parents awareness of proper operation age and necessity of surgery and side effects of cryptorchidism.


Table II. Cause of delay in proper treatment according to parents literacy, place of living and type of cryptorchidism.


Discussion
Purpose of early diagnosis and selective therapy in cryptorchidism is to avoid irreversibility of severe histological alteration able to compromise gonadal, especially germinal function. Men with a previous history of cryptorchidism are still arriving at infertility clinics, and testicular cancers appear to be 5-10 times more common after cryptorchidism than in the rest of the population (16). On the other hand the frequency of cryptorchidism is still increasing in some countries (17). The result of our study showed that 69.2% of patients were operated after 18 months, as the maximum recommended age of orchiopexy. In addition, the average of the age during the approach has been 5.34 when different level of electron microscopic changes, failure of gonocyte transformation and testicular atrophy has been accrued for patients in this age (18, 19). Guven et al in evaluation of undescended testis in older boys found that 32% of orchiopexies were performed in boys with at least 4 years of age (20). Davey showed that of 468 orchiopexies, 266 (57%) cases were more than 5 years old (21). In a large series study by Cendron et al of 759 patients, 45% underwent surgery after the age of 4 years (22). In this study, late diagnosis was the major reason accounting for delay orchiopexy which only 41.3% of cases discovered before 18 months. Other possible reasons for delay were parent's unawareness of surgery necessity and UDT complications and parent’s disregards. On the other hands, parent's unawareness is one of the important reasons for delay in treatment. We found that only 44% of parents had correct information about proper operation age and 39.8% of them had no sufficient insight. 11.2% of parents had misinformation. In necessity of surgery and awareness of cryptorchidism side effects, 40.6% of parents had correct information; while 51.7% of them had no information. Misinformation observed in 7.7% of parents. To explain the probable risk factors, parent’s literacy, place of living and type of cryptorchidism were evaluated, and there was no significant differences related to these parameters. The results of this trial confirm conclusions of previous studies. Seddon et al indicated that missed diagnosis at birth and delay in referring for treatment by physicians appear to be major factors responsible for delay diagnosis and treatment. In this regard, they recommended an intensive education of both the public and medical profession (23). Sarmah showed that failure of medical screening is most common reason for late diagnosis of cryptorchidism. Also, he recommended that physicians and other health workers undertaking surveillance procedures should be adequately trained in the technique of examining testes of young babies and children and aware to refer boys over 6 months with undescended testis to surgeons (24). Moreover, Guven et al concluded many late orchiopexies can be prevented by primary care provider and parent education to encourage early referral (20).  Also, Raghavendran et al revealed that physicians are the main responsible for the late presentation of the patients and indicated that careful physical examination and screening at birth by obstetrician, pediatrician and other practicing physicians is necessity (25). Overall, until now there have been plenty of studies performed about late diagnosis of cryptorchidism which indicates that delayed orchiopexy is still a universal problem (26-29). The superiority of our study was assessment of parents’ information about the UDT, treatment necessity and its complications. We also evaluated probable risk factor involved in delay management of cryptorchidism such as parent’s literacy, place of living and type of cryptorchidism. This study has some limitations, as well. Initially, we had no pre or post operative semen analysis in adult patients. Moreover, samples could not be taken from the testes for histopathological studies.
 
Conclusion
This study reveals that the main reasons in delayed diagnosis and treatment of UDT are 1/physician failed to diagnose UDT at birth or even during follow-up periods and 2/lack of insight in relation to parents. Therefore, education of society especially parents and careful physical examination of the babies at birth and regular follow-up until 18 months can prevent the delay in diagnosis and treatment of UDT.