دوره 19، شماره 6 - ( 4-1400 )
جلد 19 شماره 6 صفحات 578-577 |
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چکیده: (1093 مشاهده)
Thank you for the observations made, clarifications required as well as the suggestions.
We have gone through and our response is thus:
1) We understand that spermatogenesis cycle in rats lasts on an average for 56
days. We administered rats with prednisolone, then treated them with various doses
of Vernonia amygdalina, and a comparison was drawn between the groups and the
control. This comparison demonstrates the differences. We treated the rats for 21
days, which has shown to make a difference in their spermatogenesis parameters
when compared with the untreated group.. Similar studies with shorter duration of
administration have also shown difference in these sperm parameters, even with as
low as 14 days of treatment when compared to controls (1–3). In our study, the rats
were immunosuppressed with prednisolone, and then treated with low and high doses
of Vernonia amygdalina extract, to observe for the different possible effects. These
groupings were ideas conceived by the authors, which was part of the experimental
design of the study. Furthermore, studies have shown various administrations of similar
and higher doses being used (4, 5). According to the published data by Akah et al. and
Nwanjo, acute toxicity test in rats gave an LD50 of 1122 mg/kg as well as 1265.22 ± 56
mg/kg (6, 7).
We have gone through and our response is thus:
1) We understand that spermatogenesis cycle in rats lasts on an average for 56
days. We administered rats with prednisolone, then treated them with various doses
of Vernonia amygdalina, and a comparison was drawn between the groups and the
control. This comparison demonstrates the differences. We treated the rats for 21
days, which has shown to make a difference in their spermatogenesis parameters
when compared with the untreated group.. Similar studies with shorter duration of
administration have also shown difference in these sperm parameters, even with as
low as 14 days of treatment when compared to controls (1–3). In our study, the rats
were immunosuppressed with prednisolone, and then treated with low and high doses
of Vernonia amygdalina extract, to observe for the different possible effects. These
groupings were ideas conceived by the authors, which was part of the experimental
design of the study. Furthermore, studies have shown various administrations of similar
and higher doses being used (4, 5). According to the published data by Akah et al. and
Nwanjo, acute toxicity test in rats gave an LD50 of 1122 mg/kg as well as 1265.22 ± 56
mg/kg (6, 7).
نوع مطالعه: Letter to Editor |
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