Volume 21, Issue 1 (January 2023)                   IJRM 2023, 21(1): 17-32 | Back to browse issues page

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Yunaini L, Pujianto D A. Various gene modification techniques to discover molecular targets for non-hormonal male contraceptives: A review. IJRM 2023; 21 (1) :17-32
URL: http://ijrm.ir/article-1-2404-en.html
Various gene modification techniques to discover molecular targets for non-hormonal male contraceptives: A review
Luluk Yunaini * 1, Dwi Ari Pujianto2
1- Doctoral Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia. Department of Medicine Biology, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia. , luluk.yunaini@ui.ac.id
2- Departement of Medicine Biology Faculty of Medicine, Universitas Indonesia,
Abstract:   (860 Views)
The identification and characterization of relevant targets are necessary for developing nonhormonal male contraceptives. The molecules must demonstrate that they are necessary for reproduction. As a result, a sophisticated technique is required to identify the molecular targets for nonhormonal male contraceptives. Genetic modification (GM) techniques are one method that can be applied. This technique has been widely used to study gene function that effected male fertility and has resulted in the discovery of numerous nonhormonal male contraceptive target molecules. We examined GM techniques and approaches used to investigate genes involved in male fertility as potential targets for nonhormonal contraceptives. The discovery of nonhormonal contraceptive candidate molecules was increased by using GM techniques, especially the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 method. The discovery of candidate nonhormonal contraceptive molecules can be a wide-open research for the development of nonhormonal male contraceptives. Therefore, we are believing that one day nonhormonal male contraceptives will be released.
Keywords: Gene modification, Non-hormonal, Male contraceptive.
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Type of Study: Review Article | Subject: Reproductive Andrology
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