International Journal of
Reproductive Biomedicine
Tue, Jun 18, 2024
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Volume 21, Issue 12 (December 2023)
IJRM 2023, 21(12): 1013-1020 |
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Al Saeghi S, Al-Mahrouqi T, AL-Khadhuri M, AL-Ghabshi R, AL-Sabti J, Jose S et al . Parental consanguinity and ovarian reserve: A retrospective cohort study. IJRM 2023; 21 (12) :1013-1020
URL: http://ijrm.ir/article-1-3121-en.html
URL: http://ijrm.ir/article-1-3121-en.html
Shadya Al Saeghi1 
, Tamadhir Al-Mahrouqi2 , Maha AL-Khadhuri3 , Rahma AL-Ghabshi4 , Jokha AL-Sabti3 , Sachin Jose5 , Vaidyanathan Gowri * 6
, Tamadhir Al-Mahrouqi2 , Maha AL-Khadhuri3 , Rahma AL-Ghabshi4 , Jokha AL-Sabti3 , Sachin Jose5 , Vaidyanathan Gowri * 6
1- Obstetrics and Gynecology Residency Training Program, Oman Medical Specialty Board, Muscat, Oman.
2- General Foundation Program, Oman Medical Specialty Board, Muscat, Oman.
3- Obstetrics and Gynecology Department, Sultan Qaboos University and Hospital, Muscat, Oman.
4- Obstetrics and Gynecology Department, Royal Hospital, Muscat, Oman.
5- Department of Research, Oman Medical Specialty Board, Muscat, Oman.
6- Obstetrics and Gynecology Department, Sultan Qaboos University and Hospital, Muscat, Oman. , gowrie61@hotmail.com
2- General Foundation Program, Oman Medical Specialty Board, Muscat, Oman.
3- Obstetrics and Gynecology Department, Sultan Qaboos University and Hospital, Muscat, Oman.
4- Obstetrics and Gynecology Department, Royal Hospital, Muscat, Oman.
5- Department of Research, Oman Medical Specialty Board, Muscat, Oman.
6- Obstetrics and Gynecology Department, Sultan Qaboos University and Hospital, Muscat, Oman. , gowrie61@hotmail.com
Abstract: (207 Views)
Background: Infertility affects around 10-15% of couples worldwide and is both a social and medical problem. Parental consanguinity is considered to reduce fertility reserve. Consanguineous marriages, especially first cousin marriages, are very common in Oman according to the data from the Oman National Health Survey.
Objective: This study aimed to determine whether women born to consanguineous parents have reduced ovarian reserve.
Materials and Methods: This cohort study was conducted on 414 women aged ≤ 39, treated for infertility at Sultan Qaboos University hospital and Royal hospital, Muscat, Oman from January 2019-December 2020. Each participant was interviewed and a complete history, including parental consanguinity and physical examination, were recorded. On day 2 of the menstrual cycle, serum concentration of the following was performed: follicle-stimulating hormone (FSH), luteinizing hormone, estradiol, prolactin, thyroid stimulating hormone, and anti-Müllerian hormone (AMH). AMH was done, if necessary, on other days of the cycle. Antral follicle count (AFC) was done on day 2 and 3 of the menstrual cycle.
Results: Of the 414 women, parental consanguinity was present in 40.2% of couples. In women with low AFC, parental consanguinity was present in 15.3% compared to 13.0% in the non-consanguineous group. About 15% of women with low AMH had consanguineous parents, compared to 20.2% from the non-consanguineous group. High levels of FSH were present in 6.5% and 4.2% of the consanguineous and non-consanguineous groups, respectively. No significant difference was observed in AFC with reference to body mass index.
Conclusion: The results from this study showed no statistically significant difference in low ovarian reserves (AFC, AMH, and FSH) in women whose parents had a consanguineous marriage.
Objective: This study aimed to determine whether women born to consanguineous parents have reduced ovarian reserve.
Materials and Methods: This cohort study was conducted on 414 women aged ≤ 39, treated for infertility at Sultan Qaboos University hospital and Royal hospital, Muscat, Oman from January 2019-December 2020. Each participant was interviewed and a complete history, including parental consanguinity and physical examination, were recorded. On day 2 of the menstrual cycle, serum concentration of the following was performed: follicle-stimulating hormone (FSH), luteinizing hormone, estradiol, prolactin, thyroid stimulating hormone, and anti-Müllerian hormone (AMH). AMH was done, if necessary, on other days of the cycle. Antral follicle count (AFC) was done on day 2 and 3 of the menstrual cycle.
Results: Of the 414 women, parental consanguinity was present in 40.2% of couples. In women with low AFC, parental consanguinity was present in 15.3% compared to 13.0% in the non-consanguineous group. About 15% of women with low AMH had consanguineous parents, compared to 20.2% from the non-consanguineous group. High levels of FSH were present in 6.5% and 4.2% of the consanguineous and non-consanguineous groups, respectively. No significant difference was observed in AFC with reference to body mass index.
Conclusion: The results from this study showed no statistically significant difference in low ovarian reserves (AFC, AMH, and FSH) in women whose parents had a consanguineous marriage.
Type of Study: Original Article |
Subject:
Reproductive Biology
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