International Journal of
Reproductive Biomedicine
Fri, Aug 22, 2025
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Volume 23, Issue 6 (June 2025 2025)
IJRM 2025, 23(6): 485-492 |
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Ethics code: IR.DUMS.REC.1400.027
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Poormoosavi S M, Behmanesh M A, Pourmotahari F, Tavvalapour K, Janati S. Impact of COVID-19 infection on placental histopathology and maternal-perinatal outcomes: A cross-sectional study. IJRM 2025; 23 (6) :485-492
URL: http://ijrm.ir/article-1-3464-en.html
URL: http://ijrm.ir/article-1-3464-en.html
Seyedeh Mahsa Poormoosavi1 
, Mohammad Amin Behmanesh2 , Fatemeh Pourmotahari3 , Kosar Tavvalapour4 , Sima Janati *5
, Mohammad Amin Behmanesh2 , Fatemeh Pourmotahari3 , Kosar Tavvalapour4 , Sima Janati *5
1- Department of Histology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran.
2- Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
3- Department of Biostatistics, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
4- Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
5- Department of Obstetrics and Gynecology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran. ,janati.s@dums.ac.ir; sjanati@ymail.com
2- Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
3- Department of Biostatistics, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
4- Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
5- Department of Obstetrics and Gynecology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran. ,
Abstract: (35 Views)
Background: Coronavirus disease 2019 (COVID-19) presents a broad spectrum of clinical outcomes and, unlike other coronaviruses, poses significant risks during pregnancy. A primary concern is the potential for vertical transmission from mother to fetus, affecting both maternal and fetal health.
Objective: This study aimed to investigate the placental histopathology and maternal-perinatal outcomes in mothers infected with COVID-19.
Materials and Methods: In this cross-sectional study, 40 pregnant women referred to Ganjavian hospital, Dezful, Iran for delivery from June to October 2021 were enrolled in 2 groups: group I who were women with COVID-19 on the day of delivery (n = 30) and group II who were women without COVID-19 (n = 10). Placental tissue samples were collected post-delivery to assess histopathological changes and placental weight. Additionally, maternal and neonatal characteristics including maternal age, the number of prior deliveries and pregnancies, gestational age, 1- and 5-min Apgar scores, and maternal oxygen administration, mode of delivery, and neonatal COVID-19 test results, were compared between the groups.
Results: No significant differences were found between the groups regarding maternal age, gestational age, parity, Apgar scores, placental weight, oxygen therapy, or delivery method. However, group I showed significantly higher rates of placental abnormalities such as intravillous fetal thrombosis (p = 0.002), fibrin deposition, lymphocytic infiltration, chorangiosis, edema, intervillous hemorrhage, syncytial node formation, distal villous hypoplasia, and avascular villi (p < 0.001).
Conclusion: According to our study, the placental tissue of pregnant women who have been infected with COVID-19 during their third trimester indicates tissue changes that can lead to poor exchanges between mother and fetus.
Objective: This study aimed to investigate the placental histopathology and maternal-perinatal outcomes in mothers infected with COVID-19.
Materials and Methods: In this cross-sectional study, 40 pregnant women referred to Ganjavian hospital, Dezful, Iran for delivery from June to October 2021 were enrolled in 2 groups: group I who were women with COVID-19 on the day of delivery (n = 30) and group II who were women without COVID-19 (n = 10). Placental tissue samples were collected post-delivery to assess histopathological changes and placental weight. Additionally, maternal and neonatal characteristics including maternal age, the number of prior deliveries and pregnancies, gestational age, 1- and 5-min Apgar scores, and maternal oxygen administration, mode of delivery, and neonatal COVID-19 test results, were compared between the groups.
Results: No significant differences were found between the groups regarding maternal age, gestational age, parity, Apgar scores, placental weight, oxygen therapy, or delivery method. However, group I showed significantly higher rates of placental abnormalities such as intravillous fetal thrombosis (p = 0.002), fibrin deposition, lymphocytic infiltration, chorangiosis, edema, intervillous hemorrhage, syncytial node formation, distal villous hypoplasia, and avascular villi (p < 0.001).
Conclusion: According to our study, the placental tissue of pregnant women who have been infected with COVID-19 during their third trimester indicates tissue changes that can lead to poor exchanges between mother and fetus.
Keywords: Pathology, Placenta, Pregnancy, Severe acute respiratory syndrome coronavirus 2, COVID-19.
Type of Study: Original Article |
Subject:
Reproductive Pattology
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