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Volume 11, Issue 7 (10-2013)
IJRM 2013, 11(7): 589-0 |
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Zhang Z H, Zhu H B, Li L L, Yu Y, Zhang H G, Liu R Z. Decline of semen quality and increase of leukocytes with cigarette smoking in infertile men. IJRM 2013; 11 (7) :589-0
URL: http://ijrm.ir/article-1-441-en.html
URL: http://ijrm.ir/article-1-441-en.html
1- Reproductive Medical Center, First Hospital of Jilin University, Changchun, Jilin, China
2- Department of Cell Biology, Bethune Medical College of Jilin University, Changchun, Jilin, China
2- Department of Cell Biology, Bethune Medical College of Jilin University, Changchun, Jilin, China
Abstract: (2689 Views)
Background: Previous researches about the effect of smoking on semen quality are contradictory, and the mechanism behind the harmful effect of smoking on semen quality still remains unclear until today.
Objective: The objectives of this study are evaluation of the relationship between smoking and fertility, investigation of the effects of cigarette smoking on sperm parameters and detection of presence of leukocytes within the semen of idiopathic infertile men from Northeastern China.
Materials and Methods: A retrospective study of 1512 infertile patients who visited affiliated hospitals of Jilin University from 2007-2010 were enrolled in this study. Patients were assigned into one non-smoking and one smoking group which was divided into mild, moderate and heavy subgroups. Sperm parameters (including leukocytes) and sperm morphology analysis were performed using standard techniques.
Results: Compared with non-smokers, smokers had a significant decrease in semen volumes (p=0.006), rapid progressive motility (p=0.002) and sperm viability (p=0.019); moreover, smokers had a significant increase in the levels of immotile sperms (p=0.005) and semen leukocytes (p=0.002); pH and sperm concentration were not statistically significant (p=0.789 and p=0.297 respectively). Sperm motion parameters were all lower in the smokers except for beat-cross frequency (Hz) (BCF). Further, the percentage of normal morphology sperm was decreased significantly in smokers (p=0.003), the sperm morphology was worse with increasing degree of smoking.
Conclusion: These findings suggest that smoking leads to a significant decline in semen quality and higher levels of leukocytes, thus smoking may affects the fertilization efficiency.
Objective: The objectives of this study are evaluation of the relationship between smoking and fertility, investigation of the effects of cigarette smoking on sperm parameters and detection of presence of leukocytes within the semen of idiopathic infertile men from Northeastern China.
Materials and Methods: A retrospective study of 1512 infertile patients who visited affiliated hospitals of Jilin University from 2007-2010 were enrolled in this study. Patients were assigned into one non-smoking and one smoking group which was divided into mild, moderate and heavy subgroups. Sperm parameters (including leukocytes) and sperm morphology analysis were performed using standard techniques.
Results: Compared with non-smokers, smokers had a significant decrease in semen volumes (p=0.006), rapid progressive motility (p=0.002) and sperm viability (p=0.019); moreover, smokers had a significant increase in the levels of immotile sperms (p=0.005) and semen leukocytes (p=0.002); pH and sperm concentration were not statistically significant (p=0.789 and p=0.297 respectively). Sperm motion parameters were all lower in the smokers except for beat-cross frequency (Hz) (BCF). Further, the percentage of normal morphology sperm was decreased significantly in smokers (p=0.003), the sperm morphology was worse with increasing degree of smoking.
Conclusion: These findings suggest that smoking leads to a significant decline in semen quality and higher levels of leukocytes, thus smoking may affects the fertilization efficiency.
Type of Study: Original Article |
References
1. Jung A, Eberl M, Schill WB. Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligo asthenoteratozoospermia. Reproduction 2001; 121: 595-603. [DOI:10.1530/rep.0.1210595]
2. Wogatzky J, Wirleitner B, Stecher A, Vanderzwalmen P, Neyer A, Spitzer D, et al. The combination matters- distinct impact of lifestyle factors on sperm quality: a study on semen analysis of 1683 patients according to MSOME criteria. Reprod Biol Endocrinol 2012; 10: 115. [DOI:10.1186/1477-7827-10-115]
3. Matikainen T, Perez GI, Jirisicova A, Pru JK, Schlezinger JJ, Ryu HY, et al. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet 2001; 28: 300-301. [DOI:10.1038/ng575]
4. Zenzes MT. Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update 2000; 6: 122-131. [DOI:10.1093/humupd/6.2.122]
5. Kunzle R, Mueller M, Ha¨nggi W, Birkhauser M, Drescher H, Bersinger N. Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril 2003; 79: 287-291. [DOI:10.1016/S0015-0282(02)04664-2]
6. Ozgur K, Isikoglu M, Seleker M, Donmez L. Semen quality of smoking and non-smoking men in infertile couples in a Turkish population. Arch Gynecol Obstet 2005; 271: 109-112. [DOI:10.1007/s00404-003-0572-z]
7. Pasqualotto FF, Sobreiro BP, Hallak J, Pasqualotto EB, Lucon AM. Cigarette smoking is related to a decrease in semen volume in a population of fertile men. BJU Int 2006; 97: 324-326. [DOI:10.1111/j.1464-410X.2005.05906.x]
8. Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS, Toft G, Bonde JP. Is smoking a risk factor for decreased semen quality? A cross-sectional analysis. Hum Reprod 2007; 22: 188-196. [DOI:10.1093/humrep/del364]
9. Collodel G, Moretti E. Morphology and meiotic segregation in spermatozoa from men of proven fertility. J Androl 2008; 29:106-114. [DOI:10.2164/jandrol.107.002998]
10. Tawadrous GA, Aziz AA, Mostafa T. Effect of smoking status on seminal parameters and apoptotic markers in infertile men. J Urol 2011; 186:1986-1990. [DOI:10.1016/j.juro.2011.06.061]
11. Al-Matubsi HY, Kanaan RA, Hamdan F, Salim M, Oriquat GA, Al Hanbali OA. Smoking practices in Jordanian people and their impact on semen quality and hormonal levels among adult men. Cent Eur J Public Health 2011; 19: 54-59.
12. Wong XY, Thomas CM, Merkus HM, Zielhuis GA, Doesburg WH, Steegers-Theunissen RP. Cigarette smoking and the risk of male factor subfertility: minor association between cotinine in seminal plasma and semen morphology. Fertil Steril 2000; 74: 930-935. [DOI:10.1016/S0015-0282(00)01567-3]
13. Trummer H, Habermann H, Haas J, Pummer K. The impact of cigarette smoking on human semen parameters and hormones. Hum Reprod 2002; 17: 1554-1559. [DOI:10.1093/humrep/17.6.1554]
14. Sepaniak S, Forges T, Gerard H, Foliguet B, Bene MC, Monnier-Barbarino P. The influence of cigarette smoking on human sperm quality and DNA fragmentation. Toxicology 2006; 223: 54-60. [DOI:10.1016/j.tox.2006.03.001]
15. De Jong AM, Menkveld R, Lens JW, Nienhuis SE, Rhemrev JP. Effect of alcohol intake and cigarette smoking on sperm parameters and pregnancy. Andrologia 2012; 20: 1-6.
16. World Health Organization (WHO). WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 4th Ed. Cambridge, United Kingdom: Cambridge University Press; 1999.
17. Chia SE, Lim ST, Tay SK, Lim ST. Factors associated with male infertility: a case-control study of 218 infertile and 240 fertile men. Br J Obstet Gynaecol 2000; 107: 55-61. [DOI:10.1111/j.1471-0528.2000.tb11579.x]
18. Juhl M, Anderson AM, Gronbaek M, Olsen J. Moderate alcohol consumption and waiting time to pregnancy. Hum Reprod 2001; 16: 2705-2709. [DOI:10.1093/humrep/16.12.2705]
19. Sorahan T, Prior P, Lancashire RJ, Faux SP, Hulte´n MA, Peck IM, et al. Childhood cancer and parental use of tobacco: deaths from 1971-1976. Br J Cancer 1997; 76: 1525-1531. [DOI:10.1038/bjc.1997.589]
20. Kumosani TA, Elshal MF, Al-Jonaid AA, Abduljabar HS. The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men. Clin Biochem 2008; 41: 1199-1203. [DOI:10.1016/j.clinbiochem.2008.07.013]
21. Collodel G, Capitani S, Pammolli A, Giannerini V, Geminiani M, Moretti E. Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study. J Androl 2010; 31: 108-113. [DOI:10.2164/jandrol.109.007773]
22. Elshal MF, El-Sayed IH, Elsaied MA, El-Masry SA, Kumosani TA. Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: association with cigarette smoking. Clin Biochem 2009; 42: 589-594. [DOI:10.1016/j.clinbiochem.2008.11.012]
23. Gaur DS, Talekar M, Pathak VP. Effect of cigarette smoking on semen quality of infertile men. Singapore Med J 2007; 48: 119-123.
24. Guo H, Zhang HG, Xue BG, Sha YW, Liu Y, Liu RZ. Effects of cigarette, alcohol consumption and sauna on sperm morphology. Zhonghua Nan Ke Xue 2006; 12: 215-217, 221.
25. Soares SR, Melo MA. Cigarette smoking and reproductive function. Curr Opin Obstet Gynecol 2008; 20: 281-291. [DOI:10.1097/GCO.0b013e3282fc9c1e]
26. Sofikitis N, Takenaka M, Kanakas N, Papadopoulos H, Yamamoto Y, Drakakis P, et al. Effects of cotinine on sperm motility, membrane function, and fertilizing capacity in vitro. Urol Res 2000; 28: 370-375. [DOI:10.1007/s002400000138]
27. Taha EA, Ez-Aldin AM, Sayed SK, Ghandour NM, Mostafa T. Effect of smoking on sperm vitality, DNA integrity, seminal oxidative stress, zinc in fertile men. Urology 2012; 80: 822-825. [DOI:10.1016/j.urology.2012.07.002]
28. Pasqualotto FF, Umezu FM, Salvador M, Borges EJr, Sobreiro BP, Pasqualotto EB. Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study. Fertil Steril 2008; 90: 278-283. [DOI:10.1016/j.fertnstert.2008.02.123]
29. Horak S, Polanska J, Widlak P. Bulky DNA adducts in human sperm: relationship with fertility, semen quality, smoking, and environmental factors. Mutat Res 2003; 537: 53-65. [DOI:10.1016/S1383-5718(03)00051-2]
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