Volume 12, Issue 6 (8-2014)                   IJRM 2014, 12(6): 389-0 | Back to browse issues page

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Ghasemi N, Amjadi F, Salehi E, Shakeri M, Aflatoonian A, Aflatoonian R. Expression of Toll-like receptors 7-10 in human fallopian tubes. IJRM 2014; 12 (6) :389-0
URL: http://ijrm.ir/article-1-549-en.html
Expression of Toll-like receptors 7-10 in human fallopian tubes
Nasrin Ghasemi1 , Fatemehsadat Amjadi2 , Ensieh Salehi2 , Mojgan Shakeri3 , Abbas Aflatoonian1 , Reza Aflatoonian * 4
1- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran
3- Tehran Islamic Azad University of Medical Sciences, Tehran, Iran
4- Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , R.Aflatoonian@gmail.com
Abstract:   (2657 Views)
Background: The human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We and others have previously revealed that TLRs1-6 express in the female reproductive tract. However, more studies should be done to detect TLRs 7-10 in the female reproductive tract, especially in the fallopian tubes.
Objective: To examine the expression of TLRs7-10 in human fallopian tube tissue.
Materials and Methods: Using immunostaining techniques, distribution of TLR7-10 was studied in surgical sections from the uterine tubes, obtained from patients undergoing tubal ligation and hysterectomy for benign gynecological conditions. RT-PCR was used to show the existence of TLR7-10 genes in fallopian tube tissue.
Results: TLR7-10 proteins were detected in the fallopian tube epithelium, although the intensity of staining was not equal in cases. TLR7-10 genes were expressed in human fallopian tube tissue.
Conclusion: This study indicates that TLR7-10 is expressed in fallopian tubes tissues, and may play an important role in microbial recognition, and in host defense against ascending infection.
Keywords: Fallopian tube, Innate immunity, Toll like receptors (TLRs), Reproductive medicine.
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Type of Study: Original Article |
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