Volume 13, Issue 4 (5-2015)                   IJRM 2015, 13(4): 215-220 | Back to browse issues page

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Taghizadeh E, Kalantar S M, Mahdian R, Sheikhha M H, Farashahi-Yazd E, Ghasemi-Esmailabad S et al . SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique. IJRM 2015; 13 (4) :215-220
URL: http://ijrm.ir/article-1-643-en.html
SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique
Eskandar Taghizadeh1 , Seyed Mehdi Kalantar2 , Reza Mahdian3 , Mohammad Hasan Sheikhha1 , Ehsan Farashahi-Yazd1 , Saeed Ghasemi-Esmailabad1 , Zahra Shahbazi * 4
1- Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran
4- Pasteur Institute of Iran, Tehran, Iran , z_shahbazi@pasteur.ac.ir
Abstract:   (2715 Views)
Background: Sulfatase 1 ( SULF1 ) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.
Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique.
Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.
Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).
Conclusion: These findings suggest that SULF1 genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.
Keywords: SULF1 gene, Polymerase chain reaction, Restriction fragment length Polymorphysm, Single nucleotide polymorphism, Restriction endonucleases, rs6990375.
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Type of Study: Original Article |
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