Volume 13, Issue 9 (10-2015)                   IJRM 2015, 13(9): 557-562 | Back to browse issues page

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Rahiminejad M E, Moaddab A, Ebrahimi M, Rabiee S, Zamani A, Ezzati M et al . The relationship between some endometrial secretion cytokines and in vitro fertilization. IJRM 2015; 13 (9) :557-562
URL: http://ijrm.ir/article-1-680-en.html
The relationship between some endometrial secretion cytokines and in vitro fertilization
Mohammad Ehsan Rahiminejad1 , Amirhossein Moaddab * 2, Mehrnoosh Ebrahimi1 , Soghra Rabiee1 , Alireza Zamani3 , Mohammad Ezzati4 , Alireza Abdollah Shamshirsaz5
1- Department of Obstetrics & Gynecology, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran
2- Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA , moaddab@bcm.edu
3- Department of Immunology and Hematology, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran
4- Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, USA
5- Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
Abstract:   (2738 Views)
Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity.
Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein (MCP).
Materials and Methods: In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1β, TNF-α, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation.
Results: Five samples were excluded. Nine women (20%) had successful clinical pregnancies, which resulted in live birth. Other 36 women (80%) were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-α, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007, 0.005 and 0.001, respectively). However, no significant difference was revealed in IL-1β levels between two groups (p=0.614).
Conclusion: The current study suggested that lower concentrations of TNF-α, IP-10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1β, no statistically significant differences were seen between the groups with and without successful pregnancy.
Keywords: Cytokine, In vitro fertilization, Outcome, Endometrium, Implantation.
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Type of Study: Original Article |
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