Volume 15, Issue 9 (9-2017)                   IJRM 2017, 15(9): 561-568 | Back to browse issues page

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Atashpour S, Kargar Jahromi H, Kargar Jahromi Z, Maleknasab M. Comparison of the effects of Ginger extract with clomiphene citrate on sex hormones in rats with polycystic ovarian syndrome. IJRM 2017; 15 (9) :561-568
URL: http://ijrm.ir/article-1-859-en.html
Comparison of the effects of Ginger extract with clomiphene citrate on sex hormones in rats with polycystic ovarian syndrome
Shekoufeh Atashpour1 , Hossein Kargar Jahromi * 2, Zahra Kargar Jahromi3 , Mozhgan Maleknasab4
1- Research Center for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran
2- Research Center for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran. , hossein.kargarjahromy@yahoo.com
3- Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran
4- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
Abstract:   (23276 Views)
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women which affect fertility. Clomiphene citrate is used as first-line treatment for this disorder, which is associated with some complications and therapeutic resistance.
Objective: In this research, we compare the effectiveness of ginger with clomiphene on sexual hormones such as Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), estrogen and progesterone in order to treat PCOS effectively with fewer side effects.
Materials and Methods: In this experimental study, 63 adult female rats (170-200 gr) were studied and divided randomly into 9 groups as control (not received any interventional substance for 60 and 89 days), sham (were given distilled water and ethyl alcohol intraperitoneally daily for 60 and 89 days), and 7 experimental groups receiving estradiol valerate (PCOS inducing agent, intramuscular) alone and with 100 mg/kg clomiphene or different doses of ginger extract (175 and 350 mg/kg) orally daily for 60 and 89 days. Sexual hormones were analyzed and compared in different groups.
Results: Our results showed that in the PCOS-induced group, LH and estrogen concentration increased while progesterone and FSH concentration decreased remarkably (p<0.05) as compared to control group. Furthermore, in groups receiving clomiphene and ginger extract, we demonstrated significant (p<0.05) improvement in hormonal secretion as compared to the PCOS-induced group. Clomiphene, compared with the lower dose of ginger extract, had a better improving effect on balancing sexual hormones in PCOS. Moreover, ginger extract at higher doses has better effects in improving PCOS.
Conclusion: As the long-term administration of clomiphene citrate has some side effects, the use of ginger as a herbal medicine without any side effects at high doses can be an effective and good alternative in improving PCOS.
zingiber officinal R. on primary dysmenorrhea. J Med Plants 2010; 9: 81-86.
Keywords: Ginger, Clomiphene citrate, Polycystic ovarian syndrome
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Type of Study: Original Article |
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