Volume 16, Issue 1 (January 2018)
IJRM 2018, 16(1): 57-60 |
Back to browse issues page
Gonul Aslan * 
1, Mahmut Ulger2 , Seda Tezcan Ulger3 , Huseyin Durukan4 , Faik Gurkan Yazici4 , Gurol Emekdas5
1, Mahmut Ulger2 , Seda Tezcan Ulger3 , Huseyin Durukan4 , Faik Gurkan Yazici4 , Gurol Emekdas5
1- Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkey , drgaslan@gmail.com
2- Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
3- Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkey
4- Department of Gynaecology Obstetrics and Reproductive Medicine, Faculty of Medicine, Mersin University, Mersin, Turkey
5- Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkey.
2- Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, Mersin, Turkey
3- Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkey
4- Department of Gynaecology Obstetrics and Reproductive Medicine, Faculty of Medicine, Mersin University, Mersin, Turkey
5- Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Abstract: (7243 Views)
Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Genital TB (GTB) is a form of extrapulmonary TB that occurs more frequently in women, in whom it classically presents in association with menstrual irregularity, pregnancy loss and short and long-term sequelae especially infertility in infected women. Patients with GTB are usually young women diagnosed during workup for infertility. GTB is rare in postmenopausal women and responsible for only approximately 1% of postmenopausal bleeding. In this study, we aimed to evaluate the laboratory, clinical and demographic characteristics of female GTB cases.
Case: We presented four female GTB cases with distinct clinical symptoms. All patients have no history of TB, and no acid-fast bacilli were seen in smears prepared from the clinical materials of the patients. Histopathological examinations revealed granulomatous inflammation in all patients.
Conclusion: In the light of the clinical features of these cases we aimed to emphasize that, female GTB must be taken into account in the patients with different clinical symptoms like postmenopausal bleeding, menometrorrhagia, infertility, and menstrual irregularities. We believe that these symptoms will be helpful for the diagnosis and treatment of female GTB.
Case: We presented four female GTB cases with distinct clinical symptoms. All patients have no history of TB, and no acid-fast bacilli were seen in smears prepared from the clinical materials of the patients. Histopathological examinations revealed granulomatous inflammation in all patients.
Conclusion: In the light of the clinical features of these cases we aimed to emphasize that, female GTB must be taken into account in the patients with different clinical symptoms like postmenopausal bleeding, menometrorrhagia, infertility, and menstrual irregularities. We believe that these symptoms will be helpful for the diagnosis and treatment of female GTB.
Type of Study: Case Report |
References
1. World Health Organization. Global tuberculosis report 2016. Available at: http://apps.who.int/iris/ bitstream/ 10665/250441/1/9789241565394-eng.pdf? ua=1.
2. Akbulut S, Arikanoglu Z, Basbug M. Tubercular tubo-ovarian cystic mass mimicking acute appendicitis: a case report. J Med Case Rep 2011; 5: 363. [DOI:10.1186/1752-1947-5-363]
3. Ghosh K, Ghosh K, Chowdhury JR. Tuberculosis and female reproductive health. J Postgrad Med 2011; 57: 307-313. [DOI:10.4103/0022-3859.90082]
4. Sharma JB, Singh N, Dharmendra S, Singh UB, P V, Kumar S, et al. Six months versus nine months anti-tuberculous therapy for female genital tuberculosis: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol 2016; 203: 264-273. [DOI:10.1016/j.ejogrb.2016.05.035]
5. Thangappah RB, Paramasivan CN, Narayanan S. Evaluating PCR, culture & histopathology in the diagnosis of female genital tuberculosis. Indian J Med Res 2011; 134: 40-46.
6. Sachan R, Patel ML, Gupta P, Verma AK. Genital tuberculosis with variable presentation: a series of three cases. BMJ Case Rep 2012; pii: bcr2012006665. [DOI:10.1136/bcr-2012-006665]
7. Eftekhar M, Pourmasumi S, Sabeti P, Aflatoonian A, Sheikhha MH. Mycobacterium tuberculosis infection in women with unexplained infertility. Int J Reprod Biomed 2015; 13: 749-754. [DOI:10.29252/ijrm.13.12.749]
8. Güngördük K, Ulker V, Sahbaz A, Ark C, Tekirdag AI. Postmenopausal tuberculosis endometritis. Infect Dis Obstet Gynecol 2007; 2007: 27028. [DOI:10.1155/2007/27028]
9. Yassaee F, Farzaneh F. Familial tuberculosis mimicking advanced ovarian cancer. Infect Dis Obstet Gynecol 2009; 2009: 736018. [DOI:10.1155/2009/736018]
10. Lee LV. Solid Media for Isolation: Mycobacteriology and Antimycobacterial Susceptibility Testing. In: Isenberg HD. Clinical Microbiology Procedures Handbook. Washington DC, ASM Press; 2004: 7.3.1-7.3.4.
11. Weitzman I. Acid-Fast Stains: Mycobacteriology and Antimycobacterial Susceptibility Testing. In: Isenberg HD. Clinical Microbiology Procedures Handbook. Washington DC, ASM Press; 2004: 7.2.1.-7.2.4.
12. Lee LV. Procedures for identification from culture: Mycobacteriology and Antimycobacterial Susceptibility Testing. In: Isenberg HD. Clinical Microbiology Procedures Handbook. Washington DC, ASM Press; 2004: 7.6.1.1-7.6.1.12.
13. Telenti A, Marchesi F, Balz M, Bally F, Böttger EC, Bodmer T. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol 1993; 31: 175-178.
14. Caliskan E, Cakiroglu Y, Sofuoglu K, Doger E, Akar ME, Ozkan SO. Effects of salpingectomy and antituberculosis treatments on fertility results in patients with genital tuberculosis. J Obstet Gynaecol Res 2014; 40: 2104-2109. [DOI:10.1111/jog.12450]
15. Neonakis IK, Spandidos DA, Petinaki E. Female genital tuberculosis: A review. Scand J Infect Dis 2011; 43: 564-572. [DOI:10.3109/00365548.2011.568523]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |