Volume 16, Issue 11 (November 2018)                   IJRM 2018, 16(11): 689-696 | Back to browse issues page

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Azizi E, Naji M, Shabani-Nashtaei M, Sobhani A, Najafi A, Amidi F. Association of serum content of 25-hydroxy vitamin D with semen quality in normozoospermic and oligoasthenoteratozoospermic men. IJRM 2018; 16 (11) :689-696
URL: http://ijrm.ir/article-1-1297-en.html
Association of serum content of 25-hydroxy vitamin D with semen quality in normozoospermic and oligoasthenoteratozoospermic men
Elham Azizi1 , Mohammad Naji2 , Maryam Shabani-Nashtaei1 , Aligholi Sobhani1 , Atefeh Najafi1 , Fardin Amidi * 3
1- Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Famidi@sina.tums.ac.ir
Abstract:   (4314 Views)
Background: Vitamin D has multifaceted function in human reproductive physiology. It has been revealed that vitamin D is involved in spermatogenesis, and semen quality can be linked to vitamin D status in men.
Objective: Evaluating the correlation of 25-hydroxy vitamin D (25-OHD) levels in serum with basic and advanced semen parameters and essential determinants of spermatozoa function.
Materials and Methods: Participants were categorized, based on semen parameters, into normozoospermic (NS) and oligoasthenoteratozoospermic (OAT) men. Serum level of 25-OHD was measured. Apoptotic status of spermatozoa, mitochondrial membrane potential and reactive oxygen species content of semen were assessed.
Results: Difference of 25-OHD concentration in serum of NS men versus OAT ones did not meet significance threshold. DNA fragmentation, reactive oxygen species content of semen and mitochondrial membrane potential state revealed significant difference between NS and OAT subjects. There were no significant differences in basic and functional semen parameters when men were stratified based on serum 25-OHD level. Taking both 25-OHD and semen categories (NS and OAT) into consideration did not indicate any significant difference in studied parameters. Total motility of spermatozoa was positively correlated with serum concentration of 25-OHD in all studied subjects. In addition, normal morphology of spermatozoa in NS men revealed a positive and significant correlation with levels of 25-OHD in serum.
Conclusion: Vitamin D may affect motility and morphology of spermatozoa. Lower content of serum vitamin D may affect fertility of men and should be considered in examination of men with abnormal spermogram.
Keywords: Vitamin D, Infertility, DNA fragmentation, Reactive oxygen species, Semen analysis
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Type of Study: Original Article |
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