Volume 16, Issue 11 (November 2018)                   IJRM 2018, 16(11): 689-696 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Azizi E, Naji M, Shabani-Nashtaei M, Sobhani A, Najafi A, Amidi F. Association of serum content of 25-hydroxy vitamin D with semen quality in normozoospermic and oligoasthenoteratozoospermic men. IJRM 2018; 16 (11) :689-696
URL: http://ijrm.ir/article-1-1297-en.html
Association of serum content of 25-hydroxy vitamin D with semen quality in normozoospermic and oligoasthenoteratozoospermic men
Elham Azizi1 , Mohammad Naji2 , Maryam Shabani-Nashtaei1 , Aligholi Sobhani1 , Atefeh Najafi1 , Fardin Amidi * 3
1- Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Famidi@sina.tums.ac.ir
Abstract:   (4561 Views)
Background: Vitamin D has multifaceted function in human reproductive physiology. It has been revealed that vitamin D is involved in spermatogenesis, and semen quality can be linked to vitamin D status in men.
Objective: Evaluating the correlation of 25-hydroxy vitamin D (25-OHD) levels in serum with basic and advanced semen parameters and essential determinants of spermatozoa function.
Materials and Methods: Participants were categorized, based on semen parameters, into normozoospermic (NS) and oligoasthenoteratozoospermic (OAT) men. Serum level of 25-OHD was measured. Apoptotic status of spermatozoa, mitochondrial membrane potential and reactive oxygen species content of semen were assessed.
Results: Difference of 25-OHD concentration in serum of NS men versus OAT ones did not meet significance threshold. DNA fragmentation, reactive oxygen species content of semen and mitochondrial membrane potential state revealed significant difference between NS and OAT subjects. There were no significant differences in basic and functional semen parameters when men were stratified based on serum 25-OHD level. Taking both 25-OHD and semen categories (NS and OAT) into consideration did not indicate any significant difference in studied parameters. Total motility of spermatozoa was positively correlated with serum concentration of 25-OHD in all studied subjects. In addition, normal morphology of spermatozoa in NS men revealed a positive and significant correlation with levels of 25-OHD in serum.
Conclusion: Vitamin D may affect motility and morphology of spermatozoa. Lower content of serum vitamin D may affect fertility of men and should be considered in examination of men with abnormal spermogram.
Keywords: Vitamin D, Infertility, DNA fragmentation, Reactive oxygen species, Semen analysis
Full-Text [PDF 621 kb]   (1001 Downloads) |   |   Full-Text (HTML)  (396 Views)  
Type of Study: Original Article |
References
1. Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013; 67: 225-235. [DOI:10.1111/ijcp.12031]
2. Blomberg Jensen M. Vitamin D and male reproduction. Nat Rev Endocrinol 2014; 10: 175-186. [DOI:10.1038/nrendo.2013.262]
3. Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1α, 25 (OH) 2 vitamin D 3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 2011; 25: 543-559. [DOI:10.1016/j.beem.2011.05.010]
4. Banakar MC, Paramasivan SK, Chattopadhyay MB, Datta S, Chakraborty P, Chatterjee M, et al. 1alpha, 25-dihydroxyvitamin D~ 3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital. World J Gastroenterol 2004; 10: 1268-1275. [DOI:10.3748/wjg.v10.i9.1268]
5. Krishnan AV, Trump DL, Johnson CS, Feldman D. The role of vitamin D in cancer prevention and treatment. Rheum Dis Clin North Am 2012; 38: 161-178. [DOI:10.1016/j.rdc.2012.03.014]
6. Norman AW, Mizwicki MT, Norman DP. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 2004; 3: 27-41. [DOI:10.1038/nrd1283]
7. Dixon KM, Deo SS, Norman AW, Bishop JE, Halliday GM, Reeve VE, et al. In vivo relevance for photoprotection by the vitamin D rapid response pathway. J Steroid Biochem Mol Biol 2007; 103: 451-456. [DOI:10.1016/j.jsbmb.2006.11.016]
8. Pearce SH, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ 2010; 340: 142-147. [DOI:10.1136/bmj.b5664]
9. Rahnavard Z, Eybpoosh S, Homami MR, Meybodi HA, Azemati B, Heshmat R, et al. Vitamin D deficiency in healthy male population: Results of the Iranian multi-center osteoporosis study. Iran J Public Health 2010; 39: 45-52.
10. Tabrizi R, Moosazadeh M, Akbari M, Dabbaghmanesh MH, Mohamadkhani M, Asemi Z, et al. High prevalence of vitamin d deficiency among iranian population: A systematic review and meta-analysis. Iran J Med Sci 2018; 43: 125-139.
11. Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology 2006; 68: 1345-1349. [DOI:10.1016/j.urology.2006.09.011]
12. Habib FK, Maddy SQ, Gelly KJ. Characterisation of receptors for 1,25-dihydroxyvitamin D3 in the human testis. J Steroid Biochem 1990; 35: 195-199. [DOI:10.1016/0022-4731(90)90274-V]
13. Blomberg Jensen M, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod 2010; 25: 1303-1311. [DOI:10.1093/humrep/deq024]
14. Aquila S, Guido C, Middea E, Perrotta I, Bruno R, Pellegrino M, et al. Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) regulates different aspects of human sperm biology and metabolism. Reprod Biol Endocrinol 2009; 7: 140-153. [DOI:10.1186/1477-7827-7-140]
15. Aquila S, Guido C, Perrotta I, Tripepi S, Nastro A, Andò S. Human sperm anatomy: ultrastructural localization of 1α, 25‐dihydroxyvitamin D3 receptor and its possible role in the human male gamete. J Anat 2008; 213: 555-564. [DOI:10.1111/j.1469-7580.2008.00975.x]
16. Yang B, Sun H, Wan Y, Wang H, Qin W, Yang L, et al. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int J Androl 2012; 35: 783-792. [DOI:10.1111/j.1365-2605.2012.01287.x]
17. Tirabassi G, Cutini M, Muscogiuri G, Delli Muti N, Corona G, Galdiero M, et al. Association between vitamin D and sperm parameters: Clinical evidence. Endocrine 2017; 58: 194-198. [DOI:10.1007/s12020-016-1198-9]
18. Abbasihormozi S, Kouhkan A, Alizadeh AR, Shahverdi AH, Nasr-Esfahani MH, Sadeghi Gilani MA, et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5: 113-118. [DOI:10.1111/andr.12280]
19. Amaral S, Redmann K, Sanchez V, Mallidis C, Ramalho-Santos J, Schlatt S. UVB irradiation as a tool to assess ROS-induced damage in human spermatozoa. Andrology 2013; 1: 707-714. [DOI:10.1111/j.2047-2927.2013.00098.x]
20. Nair-Shalliker V, Armstrong BK, Fenech M. Does vitamin D protect against DNA damage? Mutat Res 2012; 733: 50-57. [DOI:10.1016/j.mrfmmm.2012.02.005]
21. Chatterjee M. Vitamin D and genomic stability. Mutat Res 2001; 475: 69-87. [DOI:10.1016/S0027-5107(01)00080-X]
22. Bounartzi T, Dafopoulos K, Anifandis G, Messini CI, Koutsonikou C, Kouris S, et al. Pregnancy prediction by free sperm DNA and sperm DNA fragmentation in semen specimens of IVF/ICSI-ET patients. Hum Fertil 2016; 19: 56-62. [DOI:10.3109/14647273.2016.1157629]
23. Simon L, Murphy K, Shamsi MB, Liu L, Emery B, Aston KI, et al. Paternal influence of sperm DNA integrity on early embryonic development. Hum Reprod 2014; 29: 2402-2412 [DOI:10.1093/humrep/deu228]
24. Organization WH. WHO laboratory manual for the examination and processing of human semen. World Health Organization. 2010.
25. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Reprod Biol Endocrinol 2004; 2: 12. [DOI:10.1186/1477-7827-2-12]
26. Aitken RJ, De Iuliis GN. On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod 2010; 16: 3-13. [DOI:10.1093/molehr/gap059]
27. Willson RL. Free radical-induced biological damage and the critical roles of vitamin A, vitamin C, vitamin D and vitamin E and of copper, iron, selenium and zinc. J Nutr Sci Vitaminol 1992; 38: 541-544. [DOI:10.3177/jnsv.38.Special_541]
28. Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 2012; 14: 855-859. [DOI:10.1038/aja.2012.77]
29. Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 2011; 95: 1000-1004. [DOI:10.1016/j.fertnstert.2010.11.002]
30. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012; 166: 765-778. [DOI:10.1530/EJE-11-0984]
31. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94: 1314-1319. [DOI:10.1016/j.fertnstert.2009.05.019]
32. Anifandis GM, Dafopoulos K, Messini CI, Chalvatzas N, Liakos N, Pournaras S, et al. Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome. Reprod Biol Endocrinol 2010; 8: 91. [DOI:10.1186/1477-7827-8-91]
33. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads. Endocrinology 2000; 141: 1317-1324. [DOI:10.1210/endo.141.4.7403]
34. Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26: 1307-1317. [DOI:10.1093/humrep/der059]
35. Blomberg Jensen M, Jørgensen A, Nielsen JE, Bjerrum PJ, Skalkam M, Petersen JH, et al. Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. Int J Androl 2012; 35: 499-510. [DOI:10.1111/j.1365-2605.2012.01256.x]
36. Blomberg Jensen M, Gerner Lawaetz J, Andersson AM, Petersen JH, Nordkap L, Bang AK, et al. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Hum Reprod 2016; 31: 1875-1885. [DOI:10.1093/humrep/dew152]
37. Zhu CL, Xu QF, Li SX, Wei YC, Zhu GC, Yang C, et al. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia 2016; 48: 1261-1266. [DOI:10.1111/and.12570]
38. Tak YJ, Lee JG, Kim YJ, Park NC, Kim SS, Lee S, et al. Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study. Asian J Androl 2015; 17: 324-328. [DOI:10.4103/1008-682X.142137]
39. Hollis BW. Assessment and interpretation of circulating 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D in the clinical environment. Endocrinol Metab Clin North Am 2010; 39: 271-286. [DOI:10.1016/j.ecl.2010.02.012]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb