Volume 18, Issue 8 (August 2020)                   IJRM 2020, 18(8): 591-596 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Davar R, Hoseini M, Saeed L. Vaginal compared oral administration of estradiol in women with thin endometrium: A cross-sectional study. IJRM 2020; 18 (8) :591-596
URL: http://ijrm.ir/article-1-1396-en.html
1- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , masroorehoseini@yahoo.com
Abstract:   (27185 Views)
Background: Endometrial thickness is regarded as an indicator of the receptivity of the endometrium. Patients preparing for frozen embryo transfer need some interventions in case their endometrium is thin.
Objective: This study aimed to compare the clinical outcomes of oral administration of estradiol valerate with its vaginal type in women with inappropriate endometrial thickness.
Materials and Methods: This cross sectional study comprised of 79 women (cycles) who had undergone frozen-thawed embryo transfer. On the 13th day of the cycle, vaginal sonography was performed in case the thickness of the endometrium was < 7 mm; in the oral group, the patients continued using oral estradiol valerate tablet. However, in the vaginal group, the participants applied estradiol valerate tablet vaginally. Finally, the chemical and clinical pregnancy rate, also, early miscarriage rate were compared between the two groups.
Results: The early miscarriage rate was lower in the vaginal group in comparison with the oral group (p = 0.040). Women in the vaginal group showed a lower rate of chemical pregnancy compared to the oral group, but this difference was not statistically significant (25.0 vs. 34.4%, p = 0.440). The rate of clinical pregnancy in the two groups was not statistically significant, although the vaginal group had a higher pregnancy rate (22.5% vs. 15.6%, p = 0.464), especially in women older than 34 years (37.5% vs. 11.1%, p = 0.355).
Conclusion: Vaginal administration of estradiol tablet in women with thin endometrium leads to a lower rate of early miscarriage.
Full-Text [PDF 264 kb]   (1066 Downloads) |   |   Full-Text (HTML)  (578 Views)  
Type of Study: Original Article | Subject: Fertility & Infertility

1. He W, Lv J, Lin H, Ou J, Tao X, Xing W, et al. Are the estrogen levels on the day of frozen-thawed embryo transfer related to the outcomes in hormonal replacement treatment cycles? Int J Clin Exp Med 2018; 11: 7200-7207.
2. Chen MJ, Yang JH, Peng FH, Chen SU, Ho HN, Yang YS. Extended estrogen administration for women with thin endometrium in frozen-thawed in-vitro fertilization programs. J Assist Reprod Genet 2006; 23: 337-342. [DOI:10.1007/s10815-006-9053-1] [PMID]
3. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwan J Obstet Gynecol 2018; 57: 810-813. [DOI:10.1016/j.tjog.2018.10.007] [PMID]
4. Liao X, Li Z, Dong X, Zhang H. Comparison between oral and vaginal estrogen usage in inadequate endometrial patients for frozen-thawed blastocysts transfer. Int J Clin Exp Pathol 2014; 7: 69926997.
5. Burks H, Paulson R. Cryopreserved embryo transfer: endometrial preparation and timing. Seminars in reproductive medicine. California: Thieme Medical Publishers; 2015. [DOI:10.1055/s-0035-1546302] [PMID]
6. Groenewoud ER, Cantineau AE, Kollen BJ, Macklon NS, Cohlen BJ. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 2017; 23: 255-261. [DOI:10.1093/humupd/dmw046] [PMID]
7. El-Toukhy T, Coomarasamy A, Khairy M, Sunkara K, Seed P, Khalaf Y, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril 2008; 89: 832-839. [DOI:10.1016/j.fertnstert.2007.04.031] [PMID]
8. Liu K, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod 2018; 33: 1883-1888. [DOI:10.1093/humrep/dey281] [PMID] [PMCID]
9. Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994; 9: 1954-1957. [DOI:10.1093/oxfordjournals.humrep.a138366] [PMID]
10. Letur-Könirsch H, Guis F, Delanian S. Uterine restoration by radiation sequelae regression with combined pentoxifylline-tocopherol: a phase II study. Fertil Steril 2002; 77: 1219-1226. [DOI:10.1016/S0015-0282(02)03120-5]
11. Davar R, Miraj S, Farid Mojtahedi M. Effect of adding human chorionic gonadotropin to frozen thawed embryo transfer cycles with history of thin endometrium. Int J Reprod BioMed 2016; 14: 53-56. [DOI:10.29252/ijrm.14.1.53]
12. Dehghani Firouzabadi R, Davar R, Hojjat F, Mahdavi M. Effect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial. Iran J Reprod Med 2013; 11: 151-158.
13. Davar R, Janati S, Mohseni F, Khabazkhoob M, Asgari S. A comparison of the effects of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles: a randomized clinical trial. J Reprod Infertil 2016; 17: 97-103.
14. Gardner DK, Weissman A, Howles CM, Shoham Z. Text book of assisted reproductive techniques: CRC Press. New York: Tylor & Francis group; 2018.
15. Zolghadri J, Haghbin H, Dadras N, Behdin S. Vagifem is superior to vaginal Premarin in induction of endometrial thickness in the frozen-thawed cycle patients with refractory endometria: A randomized clinical trial. Iran J Reprod Med 2014; 12: 415-420.
16. Tourgeman DE, Slater CC, Stanczyk FZ, Paulson RJ. Endocrine and clinical effects of micronized estradiol administered vaginally or orally. Fertil Steril 2001; 75: 200-202. [DOI:10.1016/S0015-0282(00)01640-X]
17. Oike K, Ishihara K, Kikushi S. A study on the endometrial movement and serum hormonal level in connection with uterine contraction. Nihon Sanka Fujinka Gakkai Zasshi 1990; 42: 86-92.
18. Fanchin R, Righini C, Schönauer LM, Olivennes F, Cunha Filho JS, Frydman R. Vaginal versus oral E2 administration: effects on endometrial thickness, uterine perfusion, and contractility. Fertil Steril 2001; 76: 994-998. [DOI:10.1016/S0015-0282(01)02841-2]
19. Doyle N, Parikh T, Eubanks AA, DeCherney A, Healy MW, Yauger B, et al. The effect of vaginal estradiol on live birth in preparation of the endometrium in FET cycles. Fertil Steril 2017; 108 (Suppl.): e170-e171. [DOI:10.1016/j.fertnstert.2017.07.509]

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb