International Journal of
Reproductive Biomedicine
Fri, Jan 31, 2025
[Archive]
Volume 17, Issue 10 (October 2019)
IJRM 2019, 17(10): 749-756 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ghasemi A, Amjadi F, Ghazi Mirsaeed S M, Mohammad Beigi R, Ghasemi S, Moradi Y et al . The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial. IJRM 2019; 17 (10) :749-756
URL: http://ijrm.ir/article-1-1697-en.html
URL: http://ijrm.ir/article-1-1697-en.html
Afsane Ghasemi1 
, Fatemehsadat Amjadi2 , Seyedeh Masoumeh Ghazi Mirsaeed1 , Robabeh Mohammad Beigi1 , Samaneh Ghasemi1 , Yousef Moradi3 , Seyedeh Tahereh Ghazi Mirsaeed * 4
, Fatemehsadat Amjadi2 , Seyedeh Masoumeh Ghazi Mirsaeed1 , Robabeh Mohammad Beigi1 , Samaneh Ghasemi1 , Yousef Moradi3 , Seyedeh Tahereh Ghazi Mirsaeed * 4
1- Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.
2- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
4- Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran. ,dr.ghazi83@gmail.com
2- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
4- Shahid Akbar Abadi Hospital Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran. ,
Abstract: (5620 Views)
Abstract
Background: In about 40% of the couples, the cause of infertility problems is attributed to men because of low sperm production and disturbed motility of sperm. Pieces of evidence show that Myo-inositol has a potential role for the treatment of sperm morphology and male fertility.
Objective: This study aimed to determine the effect of Myo-inositol on the sperm parameters and fertility rate in patients with oligoasthenospermia treated by intrauterine insemination (IUI).
Materials and Methods: This study was a randomized clinical trial conducted on 37 patients with oligoasthenospermia treated by IUI during 2016-2017. In this study, the patients were randomly divided into two groups of oligoasthenospermia treated with (Case group) and without Myo-inositol (Control group). The case group received 0.5 ml of Myo-inositol with a concentration of 2 mg/ml and incubated at 37ºC incubator for 2 hr, but the control group had no interventions.
Results: The results of this study showed that although there was no significant difference in sperm parameters including sperm motility and concentration before processing with Myo-inositol in the case group, but there was a significant increase in sperm motility during the treatment with Myo-inositol. The therapeutic effect of this method was confirmed on induction of pregnancy in 18% of the treated patients, in such a way that was about twice greater than those who did not receive the drug.
Conclusion: According to the results of this study, the use of Myo-inositol is efficient enough to change sperm parameters to increase the chance of fertility.
Background: In about 40% of the couples, the cause of infertility problems is attributed to men because of low sperm production and disturbed motility of sperm. Pieces of evidence show that Myo-inositol has a potential role for the treatment of sperm morphology and male fertility.
Objective: This study aimed to determine the effect of Myo-inositol on the sperm parameters and fertility rate in patients with oligoasthenospermia treated by intrauterine insemination (IUI).
Materials and Methods: This study was a randomized clinical trial conducted on 37 patients with oligoasthenospermia treated by IUI during 2016-2017. In this study, the patients were randomly divided into two groups of oligoasthenospermia treated with (Case group) and without Myo-inositol (Control group). The case group received 0.5 ml of Myo-inositol with a concentration of 2 mg/ml and incubated at 37ºC incubator for 2 hr, but the control group had no interventions.
Results: The results of this study showed that although there was no significant difference in sperm parameters including sperm motility and concentration before processing with Myo-inositol in the case group, but there was a significant increase in sperm motility during the treatment with Myo-inositol. The therapeutic effect of this method was confirmed on induction of pregnancy in 18% of the treated patients, in such a way that was about twice greater than those who did not receive the drug.
Conclusion: According to the results of this study, the use of Myo-inositol is efficient enough to change sperm parameters to increase the chance of fertility.
Type of Study: Original Article |
References
1. Diaz JR, De Las Cagigas A, Rodriguez R. Micronutrient deficiencies in developing and affluent countries. Eur J Clin Nutr 2003; 57 (Suppl.): S70-72. [DOI:10.1038/sj.ejcn.1601820] [PMID]
2. Stachecki JJ, Armant DR. Transient release of calcium from inositol 1, 4, 5-trisphosphate-specific stores regulates mouse preimplantation development. Development 1996; 122: 2485-2496.
3. Beemster P, Groenen P, Steegers‐Theunissen R. Involvement of inositol in reproduction. Nutr Rev 2002; 60: 80-87. [DOI:10.1301/00296640260042748] [PMID]
4. Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci 2011; 15: 509-514.
5. Ortmeyer HK. Dietary myoinositol results in lower urine glucose and in lower postprandial plasma glucose in obese insulin resistant rhesus monkeys. Obes Res 1996; 4: 569-575. [DOI:10.1002/j.1550-8528.1996.tb00271.x] [PMID]
6. Papaleo E, Unfer V, Baillargeon JP, De Santis L, Fusi F, Brigante C, et al. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecol Endocrinol 2007; 23: 700-703. [DOI:10.1080/09513590701672405] [PMID]
7. Hinton BT, White RW, Setchell BP. Concentrations of myo-inositol in the luminal fluid of the mammalian testis and epididymis. J Reprod Fertil 1980; 58: 395-399. [DOI:10.1530/jrf.0.0580395] [PMID]
8. Colone M, Marelli G, Unfer V, Bozzuto G, Molinari A, Stringaro A. Inositol activity in oligoasthenoteratospermia--an in vitro study. Eur Rev Med Pharmacol Sci 2010; 14: 891-896.
9. Liu DY, Clarke GN, Baker HW. Hyper-osmotic condition enhances protein tyrosine phosphorylation and zona pellucida binding capacity of human sperm. Hum Reprod 2005; 21: 745-752. [DOI:10.1093/humrep/dei364] [PMID]
10. Cryns K, Shamir A, Van Acker N, Levi I, Daneels G, Goris I, et al. IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity. Neuropsychopharmacology 2008; 33: 674-684. [DOI:10.1038/sj.npp.1301431] [PMID]
11. Martínez-Heredia J, de Mateo S, Vidal-Taboada JM, Ballesca JL, Oliva R. Identification of proteomic differences in asthenozoospermic sperm samples. Hum Reprod 2008; 23: 783-791. [DOI:10.1093/humrep/den024] [PMID]
12. Speroff L, Fritz MA. Clinical gynecologic endocrinology and infertility. London; lippincott Williams & wilkins: 2005.
13. Barratt CL, Mansell S, Beaton C, Tardif S, Oxenham SK. Diagnostic tools in male infertility-the question of sperm dysfunction. Asian J Androl 2011; 13: 53-58. [DOI:10.1038/aja.2010.63] [PMID] [PMCID]
14. Tomlinson M, Lewis S, Morroll D, British Fertility Society. Sperm quality and its relationship to natural and assisted conception: British Fertility Society Guidelines for practice. Hum Fertil 2013; 16: 175-193. [DOI:10.3109/14647273.2013.807522] [PMID]
15. van der Steeg JW, Steures P, Eijkemans MJ, F Habbema JD, Hompes PG, Kremer JA, et al. Role of semen analysis in subfertile couples. Fertil Steril 2011; 95: 1013-1019. [DOI:10.1016/j.fertnstert.2010.02.024] [PMID]
16. Chauvin TR, Griswold MD. Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium. Biol Reprod 2004; 70: 744-751. [DOI:10.1095/biolreprod.103.022731] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
