Volume 21, Issue 1 (January 2023)                   IJRM 2023, 21(1): 53-60 | Back to browse issues page

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Aliani F, Haghshenas Z, Vosough Dizaj A, Arabipoor A, Vesali S, Ashrafi M. Birth prevalence of genital anomalies among males conceived by intracytoplasmic sperm injection cycles: A cross-sectional study. IJRM 2023; 21 (1) :53-60
URL: http://ijrm.ir/article-1-2295-en.html
Birth prevalence of genital anomalies among males conceived by intracytoplasmic sperm injection cycles: A cross-sectional study
Fatemeh Aliani1 , Zahra Haghshenas1 , Ahmad Vosough Dizaj2 , Arezoo Arabipoor3 , Samira Vesali4 , Mahnaz Ashrafi * 5
1- Department of Pediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
3- Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
4- Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
5- Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Science (IUMS), Tehran, Iran. , dr.mahnaz.ashrafi@gmail.com
Abstract:   (721 Views)
Background: Several studies have been conducted worldwide to evaluate the prevalence and relative risks of congenital anomalies associated with assisted reproductive technology cycles; however, there is limited data in Iran.
Objective: To investigate male genital anomalies among live births from assisted reproductive technology.
Materials and Methods: This cross-sectional study was conducted on children born after intracytoplasmic sperm injection (ICSI) at Royan Institute, Tehran, Iran from April 2013-December 2015. The prevalence of male genitalia disorders that included hypospadias, epispadias, cryptorchidism, micropenis, and vanishing testis were reported. The relationship between the cause of infertility and type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and birth weight with these male genitalia anomalies were evaluated.
Results: In total, 4409 pregnant women were followed after their ICSI cycles to evaluate genitalia anomalies in their children. Out of 5608 live births, 2614 (46.61%) newborns were male, of which 14 cases (0.54%) had genital anomalies. The prevalence of various anomalies were cryptorchidism (0.34%), hypospadias (0.038%), micropenis (0.038%), vanishing testis (0.038%), and epispadias (0.077%). No relationship was found between the cause of infertility, type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and male genital malformation (p = 0.33, p = 0.66, and p = 0.62, respectively).
Conclusion: The prevalence of each male genital anomaly after the ICSI cycle was rare and less than 0.5%; however, no significant infertility-related factor was observed with these anomalies.
Keywords: Cryptorchidism, Hypospadias, Microinjections, Prevalence, Reproductive techniques, Urogenital abnormalities.
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Type of Study: Original Article | Subject: Assisted Reproductive Technologies
References
1. Qin J, Sheng X, Wang H, Liang D, Tan H, Xia J. Assisted reproductive technology and risk of congenital malformations: A meta-analysis based on cohort studies. Arch Gynecol Obstet 2015; 292: 777-798. [DOI:10.1007/s00404-015-3707-0]
2. Chen L, Yang T, Zheng Z, Yu H, Wang H, Qin J. Birth prevalence of congenital malformations in singleton pregnancies resulting from in vitro fertilization/intracytoplasmic sperm injection worldwide: A systematic review and meta-analysis. Arch Gynecol Obstet 2018; 297: 1115-1130. [DOI:10.1007/s00404-018-4712-x]
3. Wen J, Jiang J, Ding C, Dai J, Liu Y, Xia Y, et al. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: A meta-analysis. Fertil Steril 2012; 97: 1331-1337. [DOI:10.1016/j.fertnstert.2012.02.053]
4. Hansen M, Kurinczuk JJ, Milne E, de Klerk N, Bower C. Assisted reproductive technology and birth defects: A systematic review and meta-analysis. Hum Reprod Update 2013; 19: 330-353. [DOI:10.1093/humupd/dmt006]
5. Yin L, Hang F, Gu L-J, Xu B, Ma D, Zhu G-J. Analysis of birth defects among children 3 years after conception through assisted reproductive technology in China. Birth Defects Res A Clin Mol Teratol 2013; 97: 744-749. [DOI:10.1002/bdra.23116]
6. Giorgione V, Parazzini F, Fesslova V, Cipriani S, Candiani M, Inversetti A, et al. Congenital heart defects in IVF/ICSI pregnancy: Systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018; 51: 33-42. [DOI:10.1002/uog.18932]
7. Tararbit K, Lelong N, Houyel L, Bonnet D, Goffinet F, Khoshnood B, et al. Assessing the role of multiple pregnancies in the association between tetralogy of Fallot and assisted reproductive techniques: A path-analysis approach. Orphanet J Rare Dis 2014; 9: 1750-1752. [DOI:10.1186/1750-1172-9-27]
8. Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, Rasmussen SA. Assisted reproductive technology and major structural birth defects in the United States. Hum Reprod 2009; 24: 360-366. [DOI:10.1093/humrep/den387]
9. Massaro PA, MacLellan DL, Anderson PA, Romao RLP. Does intracytoplasmic sperm injection pose an increased risk of genitourinary congenital malformations in offspring compared to in vitro fertilization? A systematic review and meta-analysis. J Urol 2015; 193: 1837-1842. [DOI:10.1016/j.juro.2014.10.113]
10. Bang JK, Lyu SW, Choi J, Lee DR, Yoon TK, Song S-H. Does infertility treatment increase male reproductive tract disorder? Urology 2013; 81: 644-648. [DOI:10.1016/j.urology.2012.12.003]
11. Benedum CM, Yazdy MM, Parker SE, Mitchell AA, Werler MM. Association of clomiphene and assisted reproductive technologies with the risk of neural tube defects. Am J Epidemiol 2016; 183: 977-987. [DOI:10.1093/aje/kwv322]
12. Boulet SL, Kirby RS, Reefhuis J, Zhang Y, Sunderam S, Cohen B, et al. Assisted reproductive technology and birth defects among liveborn infants in Florida, Massachusetts, and Michigan, 2000-2010. JAMA Pediatr 2016; 170: e154934. [DOI:10.1001/jamapediatrics.2015.4934]
13. Luke B, Brown MB, Wantman E, Forestieri NE, Browne ML, Fisher SC, et al. The risk of birth defects with conception by ART. Hum Reprod 2021; 36: 116-129. [DOI:10.1093/humrep/deaa272]
14. Liberman RF, Getz KD, Heinke D, Luke B, Stern JE, Declercq ER, et al. Assisted reproductive technology and birth defects: Effects of subfertility and multiple births. Birth Defects Res 2017; 109: 1144-1153. [DOI:10.1002/bdr2.1055]
15. Mozafari Kermani R, Nedaeifard L, Nateghi MR, Shahzadeh Fazeli A, Ahmadi E, Osia MA, et al. Congenital anomalies in infants conceived by assisted reproductive techniques. Arch Iran Med 2012; 15: 228-231.
16. Fedder J, Loft A, Parner ET, Rasmussen S, Pinborg A. Neonatal outcome and congenital malformations in children born after ICSI with testicular or epididymal sperm: A controlled national cohort study. Hum Reprod 2013; 28: 230-240. [DOI:10.1093/humrep/des377]
17. Zhang Z, Liu X, Wei C, Luo J, Shi Y, Lin T, et al. Assisted reproductive technologies and the risk of congenital urogenital tract malformations: A systematic review and meta-analysis. J Pediatr Urol 2021; 17: 9-20. [DOI:10.1016/j.jpurol.2020.11.005]
18. Cunningham G, Leveno KJ, Bloom SL, Spong CY, Dashe JS. Williams obstetrics. 24th Ed. USA: Mcgraw-hill; 2014.
19. Shepard CL, Gayheart DT, Joseph DB. Male genitourinary system. in: Tubbs RS, Shoja MM, Loukas M. Bergman's comprehensive encyclopedia of human anatomic variation. USA: Wiley Online Library; 2016. [DOI:10.1002/9781118430309.ch115]
20. Nataraja RM, Yeap E, Healy CJ, Nandhra IS, Murphy FL, Hutson JM, et al. Presence of viable germ cells in testicular regression syndrome remnants: Is routine excision indicated? A systematic review. Pediatr Surg Int 2018; 34: 353-361. [DOI:10.1007/s00383-017-4206-0]
21. Singh R, Singh K. Male infertility: Understanding, causes and treatment. Singapore: Springer; 2017. [DOI:10.1007/978-981-10-4017-7]
22. Amooei A, Kargar S. Prevalence and pathological features of cryptorchidism among Iranian children in Yazd province, central Iran. Int J Pediatr 2018; 6: 7615-7621.
23. Delnord M, Blondel B, Zeitlin J. What contributes to disparities in the preterm birth rate in European countries? Curr Opin Obstet Gynecol 2015; 27: 133-142. [DOI:10.1097/GCO.0000000000000156]
24. Ebert AK, Zwink N, Reutter HM, Jenetzky E. A prevalence estimation of exstrophy and epispadias in Germany from public health insurance data. Front Pediatr 2021; 9: 648414. [DOI:10.3389/fped.2021.648414]
25. Zwink N, Jenetzky E, Hirsch K, Reifferscheid P, Schmiedeke E, Schmidt D, et al. Assisted reproductive techniques and risk of exstrophy-epispadias complex: A German case-control study. J Urol 2013; 189: 1524-1529. [DOI:10.1016/j.juro.2012.11.108]
26. Gaspari L, Sampaio DR, Paris F, Audran F, Orsini M, Neto JB, et al. High prevalence of micropenis in 2710 male newborns from an intensive‐use pesticide area of Northeastern Brazil. Int J Androl 2012; 35: 253-264. [DOI:10.1111/j.1365-2605.2011.01241.x]
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