Volume 9, Issue 4 (7-2011)                   IJRM 2011, 9(4): 315-318 | Back to browse issues page

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Rashidi B, Nasiri R, Rahmanpour H, Shahrokh Tehraninejad E, Deldar M. Luteal phase estradiol versus luteal phase GnRH antagonist administration: their effects on antral follicular size coordination and basal hormonal levels. IJRM 2011; 9 (4) :315-318
URL: http://ijrm.ir/article-1-241-en.html
Luteal phase estradiol versus luteal phase GnRH antagonist administration: their effects on antral follicular size coordination and basal hormonal levels
Batool Rashidi1 , Roya Nasiri2 , Haleh Rahmanpour * 3, Ensieh Shahrokh Tehraninejad1 , Maryam Deldar1
1- Valie-Asr Reproductive Health Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, Aria Hospital, Faculty of Medicine, Islamic Azad University of Medical Sciences, Mashhad Branch, Mashhad, Iran
3- Department of Obstetrics and Gynecology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran , haleh509@gmail.com
Abstract:   (2778 Views)
Background: The differential efficacy between long GnRH agonist with antagonist can partly be due to the preexisting differences in the early antral follicles before ovarian stimulation.
Objective: To compare the effect of pretreatment by estradiol with GnRH antagonist on antral follicular size coordination and basal hormone levels in GNRH antagonist protocol.
Materials and Methods: On cycle day 3 (control/day 3), women underwent measurements of early antral follicles by ultrasound and serum FSH and ovarian hormones then were randomized to receive oral estradiol 4mg/day (n=15) or 3mg cetrorelix acetate (n=15) in luteal phase before subsequent antagonist protocol. Participants were re-evaluated as on control/day 3.
Results: There was a significant reduction of mean follicular sizes in each group after medical intervention (7.63±2.11 Vs. 4.30±0.92 in group A and 8.73±1.96 Vs. 4.13±1.11 in group B) (p=0.0001). The magnitude of follicular size reduction was significantly higher in group B (-4.60±2.04 Vs. -3.33±2.28) (0.027). There was a non significant attenuation of follicular size discrepancies in two groups. FSH and inhibin B levels in the day 3 of the next cycle in both groups were significantly decreased but did not have significant difference between two groups.
Conclusion: Both luteal E2 and premenstrual GnRH antagonist administration reduces the follicular sizes significantly and GnRH antagonist acts more potently than E2 in this way but attenuation of follicular size discrepancies in both treatment is not significant
Keywords: Follicular synchronization, Estradiol, GnRH antagonist
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Type of Study: Original Article |
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