Volume 20, Issue 8 (August 2022)                   IJRM 2022, 20(8): 683-690 | Back to browse issues page


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Emami F, Eftekhar M, Jalaliani S. Correlation between clinical and laboratory parameters and early pregnancy loss in assisted reproductive technology cycles: A cross-sectional study. IJRM 2022; 20 (8) :683-690
URL: http://ijrm.ir/article-1-2475-en.html
1- Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Abortion Research Center, Yazd Reproduction Sciences Institiute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , eftekharmaryam@yahoo.com eftekharmaryam@yahoo.com
Abstract:   (722 Views)
Background: The miscarriage rate after pregnancy resulting from assisted reproductive technology (ART) is about 20%, roughly half of which is biochemical. The correlations between the number and quality of oocytes, estradiol level and early pregnancy loss have not been fully clarified.
Objective: This study aimed to examine the clinical and laboratory parameter effects on early abortion in ART cycles.
Materials and Methods: In this cross-sectional study, 408 women who were ART candidates and were referred to the Yazd Infertility and Research Center, Yazd, Iran during March 2017 to March 2020 participated. Women who had a fresh embryo transferred and who had a positive beta human chorionic gonadotropin serum test were included in the study. The Anti-Müllerian hormone (AMH) level, embryo quality, oocyte number, progesterone level, estradiol level, and maternal age were extracted from the medical records.
Results: No significant difference was observed in the age, mean estradiol and progesterone levels on trigger day, number of MII oocytes, and embryo quality between the groups (p = 0.19, 0.42, 0.07, 0.34 and 0.20, respectively). No statistically significant difference was found between the 3 groups of AMH level (p = 0.20). After evaluation using logistic regression, the rate of negative clinical pregnancies was higher in the group with AMH < 1 ng/ml. However, this was not found to be statistically significant.
Conclusion: We did not find any correlation between early abortion and AMH levels, embryo quality, oocyte number, progesterone level, estradiol level, or maternal age.
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References
1. Gunby J, Daya S, IVF Directors Group of the Canadian Fertility and Andrology Society. Assisted reproductive technologies (ART) in Canada: 2001 results from the Canadian ART register. Fertil Steril 2005; 84: 590-599. [DOI:10.1016/j.fertnstert.2005.03.037] [PMID]
2. Xu Q, Chen J, Wei Z, Brandon T, Zava D, Shi YE, et al. Sex hormone metabolism and threatened abortion. Med Sci Monit 2017; 23: 5041-5048. [DOI:10.12659/MSM.904500] [PMID] [PMCID]
3. Bu Zh, Hu L, Su Y, Guo Y, Zhai J, Sun YP. Factors related to early spontaneous miscarriage during IVF/ICSI treatment: An analysis of 21,485 clinical pregnancies. Reprod Biomed Online 2020; 40: 201-206. [DOI:10.1016/j.rbmo.2019.11.001] [PMID]
4. Tummers Ph, Sutter PD, Dhont M. Risk of spontaneous abortion in singleton and twin pregnancies after IVF/ICSI. Hum Reprod 2003; 18: 1720-1723. [DOI:10.1093/humrep/deg308] [PMID]
5. Magnus MC, Wilcox AJ, Morken NH, Weinberg CR, Håberg SE. Role of maternal age and pregnancy history in risk of miscarriage: Prospective register based study. BMJ 2019; 364: 1869. [DOI:10.1136/bmj.l869] [PMID] [PMCID]
6. Atasever M, Soyman Z, Demirel E, Gencdal S, Kelekci S. Diminished ovarian reserve: is it a neglected cause in the assessment of recurrent miscarriage? A cohort study. Fertil Steril 2016; 105: 1236-1240. [DOI:10.1016/j.fertnstert.2016.01.001] [PMID]
7. Zamah AM, Stephenson MD. Antimüllerian hormone and miscarriage: Fifty shades of gray. Fertil Steril 2018; 109: 1008-1009. [DOI:10.1016/j.fertnstert.2018.02.140] [PMID]
8. Hong S, Chang E, Han EJ, Min SG, Kim S, Kang MK, et al. The anti-mullerian hormone as a predictor of early pregnancy loss in subfertile women. Syst Biol Reprod Med 2020; 66: 370-377. [DOI:10.1080/19396368.2020.1806944] [PMID]
9. Lin PY, Huang FJ, Kung FT, Chiang HJ, Lin YJ, Lin YC, et al. Evaluation of serum anti-Mullerian hormone as a biomarker of early ovarian aging in young women undergoing IVF/ICSI cycle. Int J Clin Exp Pathol 2014; 7: 6245-6253.
10. Yarde F, Maas AHEM, Franx A, Eijkemans MJC, Drost JT, Van Rijn BB, et al. Serum AMH levels in women with a history of preeclampsia suggest a role for vascular factors in ovarian aging. J Clin Endocrinol Metab 2014; 99: 579-586. [DOI:10.1210/jc.2013-2902] [PMID]
11. Stegmann BJ, Santillan M, Leader B, Smith E, Santillan D. Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth. Fertil Steril 2015; 104: 347-355. [DOI:10.1016/j.fertnstert.2015.04.044] [PMID] [PMCID]
12. Tarasconi B, Tadros T, Ayoubi JM, Belloc S, de Ziegler D, Fanchin R. Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer. Fertil Steril 2017; 108: 518-524. [DOI:10.1016/j.fertnstert.2017.07.001] [PMID]
13. Broer SL, van Disseldorp J, Broeze KA, Dolleman M, Opmeer BC, Bossuyt P, et al. Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: An individual patient data approach. Hum Reprod Update 2013; 19: 26-36. [DOI:10.1093/humupd/dms041] [PMID]
14. Imudia AN, Goldman RH, Awonuga AO, Wright DL, Styer AK, Toth TL. The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles. J Assist Reprod Genet 2014; 31: 65-71. [DOI:10.1007/s10815-013-0117-8] [PMID] [PMCID]
15. Sunkara SK, Khalaf Y, Maheshwari A, Seed P, Coomarasamy A. Association between response to ovarian stimulation and miscarriage following IVF: An analysis of 124 351 IVF pregnancies. Hum Reprod 2014; 29: 1218-1224. [DOI:10.1093/humrep/deu053] [PMID]
16. Healy M, Patounakis G, Zanelotti A, Devine K, DeCherney A, Levy M, et al. Does premature elevated progesterone on the day of trigger increase spontaneous abortion rates in fresh and subsequent frozen embryo transfers? Gynecol Endocrinol 2017; 33: 472-475. [DOI:10.1080/09513590.2017.1291612] [PMID]
17. Nayak S, Ochalski ME, Fu B, Wakim KM, Chu TJ, Dong X, et al. Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: A prospective cohort study. Fertil Steril 2014; 101: 676-682. [DOI:10.1016/j.fertnstert.2013.11.022] [PMID]
18. Saharkhiz N, Salehpour S, Tavasoli M, Aghighi A. Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome. Iran J Reprod Med 2015; 13: 79-84.
19. Eftekhar M, Dehghani Firouzabadi R, Karimi H, Rahmani E. Outcome of cryopreserved-thawed embryo transfer in the GnRH agonist versus antagonist protocol. Iran J Reprod Med 2012; 10: 297-302.
20. Dokras A, Sargent I, Barlow D. Fertilization and early embryology: Human blastocyst grading: An indicator of developmental potential? Hum Reprod 1993; 8: 2119-2127. [DOI:10.1093/oxfordjournals.humrep.a137993] [PMID]
21. Lou H, Li N, Guan Y, Zhang Y, Hao D, Cui S. Association between morphologic grading and implantation rate of euploid blastocyst. J Ovarian Res 2021; 14: 18. [DOI:10.1186/s13048-021-00770-8] [PMID] [PMCID]
22. Peuranpää P, Hautamäki H, Halttunen-Nieminen M, Hydén-Granskog C, Tiitinen A. Low anti-müllerian hormone level is not a risk factor for early pregnancy loss in IVF/ICSI treatment. Hum Reprod 2020; 35: 504-515. [DOI:10.1093/humrep/deaa008] [PMID]

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