International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 120-120 |
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Vafaei Sh, Motejaded F, Ebrahimzadeh-bideskan A. O-19 Protective effect of crocin on electromagnetic field-induced testicular damage and heat shock protein A2 expression in male BALB/c mice. IJRM 2021; 19 (5) :120-120
URL: http://ijrm.ir/article-1-2951-en.html
URL: http://ijrm.ir/article-1-2951-en.html
1- Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. ,ebrahimzadehba@mums.ac.ir
2- Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. ,
Abstract: (204 Views)
Background: Exposure to electromagnetic fields (EMF) emitted from mobile phones may cause a deleterious effect on human health and may affect the male reproductive system. Crocin, a carotenoid isolated from Crocus Sativus L. (Saffron), is a phar macologically active component of saffron.
Objective: This study was conducted to investigate the protective effect of crocin on the male reproductive system of 60 day old mice after EMF exposure.
Materials and Methods: Twenty-four male BALB/c mice were randomly divided into 4 groups: 1) electromagnetic (EM) group (2100 MHZ); 2) Crocin (Cr) group (50 mg/kg); 3) Em+Cr group (2100 MHZ+50 mg/kg), and 4) Control group. Sperm parameters (count, and abnormal percent), testis weight index, testis volume, seminiferous tubule diameter, germinal epithelium thickness, luteinizing hormone, follicle-stimulating hormone and testosterone serum level, testicular Heat shock protein A2 (HspA2) immunoreactivity, and apoptosis were evaluated.
Results: HspA2 immunoreactivity, apoptosis in the germinal epithelium and abnormal sperm were increased in EM group compared with the control group (p < 0.05). Sperm count, luteinizing hormone, and testosterone serum level were decreased in the EM group compared with the control group (p < 0.05). These parameters were improved in the EM+Cr group compared with EM group significantly (p < 0.05).
Conclusion: Our findings revealed that EMF exposure leads to harmful impressions on the male reproductive system, while crocin can attenuate EMF-induced destructive effects.
Objective: This study was conducted to investigate the protective effect of crocin on the male reproductive system of 60 day old mice after EMF exposure.
Materials and Methods: Twenty-four male BALB/c mice were randomly divided into 4 groups: 1) electromagnetic (EM) group (2100 MHZ); 2) Crocin (Cr) group (50 mg/kg); 3) Em+Cr group (2100 MHZ+50 mg/kg), and 4) Control group. Sperm parameters (count, and abnormal percent), testis weight index, testis volume, seminiferous tubule diameter, germinal epithelium thickness, luteinizing hormone, follicle-stimulating hormone and testosterone serum level, testicular Heat shock protein A2 (HspA2) immunoreactivity, and apoptosis were evaluated.
Results: HspA2 immunoreactivity, apoptosis in the germinal epithelium and abnormal sperm were increased in EM group compared with the control group (p < 0.05). Sperm count, luteinizing hormone, and testosterone serum level were decreased in the EM group compared with the control group (p < 0.05). These parameters were improved in the EM+Cr group compared with EM group significantly (p < 0.05).
Conclusion: Our findings revealed that EMF exposure leads to harmful impressions on the male reproductive system, while crocin can attenuate EMF-induced destructive effects.
Type of Study: Congress Abstract |
Subject:
Pregnancy Health
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