International Journal of
Reproductive Biomedicine
Tue, May 13, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 274-274 |
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Ghanabri E, Khazaei F, Niromand E, Khazaei M. P-107
Prosopis farcta improves histopathological disorders and reduces oxidative stress of testicular tissue in diabetic rats. IJRM 2021; 19 (5) :274-274
URL: http://ijrm.ir/article-1-3018-en.html
URL: http://ijrm.ir/article-1-3018-en.html
1- Department of Tissue Engineering, Tabriz University of Medical Sciences, Tabriz, Iran , e_ghanbari90@yahoo.com
2- Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract: (210 Views)
Background: Prosopis farcta (PF) has antioxidant effects and might be effective in avoiding damaging effects of diabetes on the testicular tissue.
Objective: This study purposes to examine the effect of PF on oxidative stress and the structure of testis in diabetic rats.
Materials and Methods: 32 male adult Wistar rats were randomly divided into control, PF, diabetic and diabetic/PF. Streptozotocin was administered intraperitoneally to induce diabetes mellitus in rats. PF group and PF-treated diabetic group received intraperitoneally 300 mg/kg extract of PF for 30 days. At the end of the study, the rats were weighed and dissected. Then, oxidative stress and histopathology of testis were examined.
Results: The level of malondialdehyde in diabetic rats treated with PF decreased in compared with diabetic group (p = 0.001), although PF extract increased the level of superoxide dismutase in the diabetic group (373.9 ± 16.6) (p < 0.001). Moreover, PF decreased testicular damage caused by diabetes mellitus.
Conclusion: Hydroalcoholic extract of PF improves testicular tissue structure in diabetic rats via decreasing oxidative stress.
Key words: Testis, Rat, Prosopis farcta.
Objective: This study purposes to examine the effect of PF on oxidative stress and the structure of testis in diabetic rats.
Materials and Methods: 32 male adult Wistar rats were randomly divided into control, PF, diabetic and diabetic/PF. Streptozotocin was administered intraperitoneally to induce diabetes mellitus in rats. PF group and PF-treated diabetic group received intraperitoneally 300 mg/kg extract of PF for 30 days. At the end of the study, the rats were weighed and dissected. Then, oxidative stress and histopathology of testis were examined.
Results: The level of malondialdehyde in diabetic rats treated with PF decreased in compared with diabetic group (p = 0.001), although PF extract increased the level of superoxide dismutase in the diabetic group (373.9 ± 16.6) (p < 0.001). Moreover, PF decreased testicular damage caused by diabetes mellitus.
Conclusion: Hydroalcoholic extract of PF improves testicular tissue structure in diabetic rats via decreasing oxidative stress.
Key words: Testis, Rat, Prosopis farcta.
Type of Study: Congress Abstract |
Subject:
Perinatology
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