International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 317-317 |
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Aghajani Sh, Mehrafza M, Hosseini A, Salehzadeh A, Ghasemiyan F, Eftekhari A, et al . P-150 Analysis of the influence of preimplantation genetic testing for aneuploidy results with maternal age. IJRM 2021; 19 (5) :317-317
URL: http://ijrm.ir/article-1-3060-en.html
URL: http://ijrm.ir/article-1-3060-en.html
Aghajani Sh *1 
, Mehrafza M2 , Hosseini A2 , Salehzadeh A3 , Ghasemiyan F4 , Eftekhari A2 , Vahabzadeh H2 , Porseifi G2
, Mehrafza M2 , Hosseini A2 , Salehzadeh A3 , Ghasemiyan F4 , Eftekhari A2 , Vahabzadeh H2 , Porseifi G2
1- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran. Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran. , shahrzadaghajani1987@gmail.com
2- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.
4- Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
2- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.
4- Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
Abstract: (273 Views)
Background: Assisted reproduction techniques and the preimplantation genetic test for aneuploidies help couples with fertility problems to achieve a healthy live birth worldwide. There is a possible correlation between chromosomal aneuploidy and maternal age.
Objective: Evaluating the effect of maternal age on aneuploidy, blastocyst rate, embryo development, and pregnancy outcomes in patients undergoing frozen embryo transfer.
Materials and Methods: This study included an analysis of X, Y, 13, 18, and 21 chromosomes identified by fluorescence in situ hybridization method in embryos from couples undergoing Assisted reproduction techniques and preimplantation genetic test for aneuploidies. The present study included 277 embryos between February 2018 and June 2020. Women were divided into four age groups: ≤ 35, 36-40, 41-45, and ≥ 45 yr. Primary outcomes were the rate of aneuploidy, blastocyst, and pregnancy. Statistical analyzes were performed using SPSS software version 23 and the data were analyzed using the χ2 test. The p < 0.05 was considered statistically significant.
Results: Significant differences among maternal age groups were found in the chemical pregnancy (p < 0.001) outcomes. The blastocyst rates (p = 0.02), early pregnancy loss (p < 0.001), and clinical pregnancy loss (p < 0.001) were related significantly with maternal age. In females with age > 40 yrs. old, there was no euploid blastocyst. Increasing maternal age significantly increases the rate of aneuploidy in sex chromosomes in frozenthawed embryo transfer and fresh cycles (p < 0.001).
Conclusion: The present study results found a significant relationship between maternal age and embryo aneuploidy, and showed that the increasing female ages and aneuploidy rate is related together. A negative association was found between maternal age and blastocyst rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth rates in the couple from Intracytoplasmic sperm injection cycles.
Objective: Evaluating the effect of maternal age on aneuploidy, blastocyst rate, embryo development, and pregnancy outcomes in patients undergoing frozen embryo transfer.
Materials and Methods: This study included an analysis of X, Y, 13, 18, and 21 chromosomes identified by fluorescence in situ hybridization method in embryos from couples undergoing Assisted reproduction techniques and preimplantation genetic test for aneuploidies. The present study included 277 embryos between February 2018 and June 2020. Women were divided into four age groups: ≤ 35, 36-40, 41-45, and ≥ 45 yr. Primary outcomes were the rate of aneuploidy, blastocyst, and pregnancy. Statistical analyzes were performed using SPSS software version 23 and the data were analyzed using the χ2 test. The p < 0.05 was considered statistically significant.
Results: Significant differences among maternal age groups were found in the chemical pregnancy (p < 0.001) outcomes. The blastocyst rates (p = 0.02), early pregnancy loss (p < 0.001), and clinical pregnancy loss (p < 0.001) were related significantly with maternal age. In females with age > 40 yrs. old, there was no euploid blastocyst. Increasing maternal age significantly increases the rate of aneuploidy in sex chromosomes in frozenthawed embryo transfer and fresh cycles (p < 0.001).
Conclusion: The present study results found a significant relationship between maternal age and embryo aneuploidy, and showed that the increasing female ages and aneuploidy rate is related together. A negative association was found between maternal age and blastocyst rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth rates in the couple from Intracytoplasmic sperm injection cycles.
Type of Study: Congress Abstract |
Subject:
Reproductive Genetics
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